姓名 冯善宇 职称 教授 所在
部门 免疫学系 研究
方向 自身性炎症反应中的免疫信号转导与调控
办公室 基础医学大楼14楼东 办公
电话 ** 电子
邮箱 shanefung@tmu.edu.cn
教育背景
博士 2003.05-2008.03 加拿大滑铁卢大学，化学工程系（生物医学工程专业） 导师：Prof. Pu Chen（加拿大工程院士）
硕士 2000.09-2002.10 加拿大滑铁卢大学，化学工程系（生物医学工程专业） 导师：Prof. Pu Chen（加拿大工程院士）
学士 1993.09-1997.06 国立台湾大学，化学工程系 导师：谢学真教授

工作经历
2018.04- 天津医科大学基础医学院免疫系 教授
2012.01-2018-08 加拿大英属哥伦比亚大学医学院，BC省儿童医院研究院 副研究员（Research Associate）
2008.07-2011.09 加拿大多伦多大学医学院，大学健康网络 博士后

研究成果（本人具有代表性的论著、论文及主持的科研项目）
论著
及编
著 　代表性论著：
　(1) S.Y. Fung, S.E. Turvey (2018) TIR signaling pathway deficiency: HOIL1 deficiency in Encyclopedia of Medical Immunology. Immunodeficiency Diseases. Edited by I.R. Mackay, N.R. Rose, J. Orange and F. Bonilla. Springer Nature Publishers. (online)
　(2) S.Y. Fung, Y. Hong, S.S. Dhadwar, X. Zhao, P. Chen (2005) Self-assembly of ionic-complementary peptides and their applications in nanobiotechnology in Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology. Edited by H.S. Nalwa American Scientific Publishers. Stevenson Ranch, USA, Chapter 1:2-66.
　(3) S.Y. Fung, Y. Hong, C. Keyes-Baig, P. Chen (2005) Self-assembly of peptides and its potential applications in Molecular Interfacial Phenomena of Polymers and Biopolymers. Edited by P. Chen Woodhead Publishing Limited, Cambridge, UK, Chapter 12:421-474.

论文 　代表性论文：
　(1) J. Quancard^#, T. Klein^#, S.Y. Fung^#, M. Renatus^#, N. Aubin, L. Isra?l, J. J. Priatel, S. Kang, M.A. Blank, R.I. Viner, J. Blank, A. Schlapbach, P. Erbel, R. Hersperger, S.E. Turvey, J. Eder, F. Bornancin*, C.M. Overall*. An allosteric inhibitor rescues mutant MALT1 and lymphocyte function in an immunodeficient patient. Nature Chemical Biology 2019 15:304-313 (IF:12.154)
　(2) T. Klein^#, S.Y. Fung^#, F. Renner^#, M.A. Blank, A. Dufour, J.J. Priatel, M. Bolger-Munro, J.M. Scrull, S. Kang, P. Schweigler, S. Melkko, M.R. Gold, R.I. Viner, C.H. Régnier*, S.E. Turvey*, C.M. Overall*. The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-kB signaling. Nature Communications 2015 6:8777 doi: 10.1038/ncomms9777 (IF:11.878; citation:56)
　(3) M.L. Mckinnon^#, J. Rozmus^#, S.Y. Fung^#, A.F. Hirschfeld, K.L. Del Bel, L. Thomas, N. Marr, S.D. Martin, A.K. Marwaha, R. Tan, C. Senger, A. Tsang, J. Prendiville, A.K. Junker, M. Seear, K.R. Schultz, L.M. Sly, R.A. Holt, M.S. Patel, J.M. Friedman, S.E. Turvey*. Combined immunodeficiency associated with homozygous MALT1 mutation. Journal of Allergy and Clinical Immunology 2014 133:1458-1462 e7 (IF:14.110; citation:47)
　(4) S.Y. Fung, V. Sofiyev, J. Schneiderman, A.F. Hirschfeld, R.E. Victor, K. Woods, J.S. Piotrowski, R. Deshpande, C. Sheena, S.C. Li, N.J. de Voogd, C.L. Myers, C. Boone, R.J. Andersen, S.E. Turvey*. Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis. ACS Chemical Biology 2014 9:247-257 (IF:4.374; citation:11)
　(5) R. Bawa^#, S.Y. Fung^#, A. Shiozaki, H. Yang, G. Zheng, S. Keshavjee, M. Liu*. Self-assembling peptide based nanoparticles enhance cellular delivery of the hydrophobic anticancer drug ellipticine through a caveolin-dependent endocytotic mechanism. Nanomedicine: Nanotechnology Biology and Medicine 2012 8:647-654 (IF:5.570; citation:32)
　(6) T. Oyaizu^#, S.Y. Fung^#, A. Shiozaki, Z. Guan, Q. Zhang, C.C. dos Santos, B. Han, M. Mura, S. Keshavjee, M. Liu*. Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion induced acute lung injury. Intensive Care Medicine 2012 38:894-905 (IF:18.967; citation:30)
　(7) S.Y. Fung, T. Oyaizu, H. Yang, Y. Yuan, B. Han, S. Keshavjee, M. Liu*. The potential of nanoscale combinations of self-assembling peptides and amino acids of the Src tyrosine kinase inhibitor in acute lung injury therapy. Biomaterials 2011 32:4000-4008 (IF:10.273; citation:18)
　(8) S.Y. Fung^#, H. Yang^#, P. Sadatmousavi, Y. Sheng, T. Mamo, R. Nazarian, P. Chen*. Amino acid pairing for de novo design of self-assembling peptides and their drug delivery potentials. Advanced Functional Materials 2011 21:2456-2464 (IF:15.621; citation:28)
　(9) S.Y. Fung, H. Yang, P.T. Bhola, P. Sadatmousavi, E. Muzar, M. Liu, P. Chen*. Self-assembling peptide as a potential carrier for hydrophobic anticancer drug ellipticine: complexation, release and in vitro delivery. Advanced Functional Materials 2009 19:74-83 (IF:15.621; citation:65)
（#:第一作者；*:通讯作者）

科研
项目 　2014.05-2017.01 项目：理解一类全新的因MALT1蛋白变异造成的人类原发性免疫缺陷症；来源：加拿大卫生研究院基金；40.1万加元；共同主持（第2）；已结题
　2013.05-2018.03 项目：探索新的Toll样受体信号抑制剂；来源：加拿大自然科学和工程研究理士会基金；18万加元；共同主持（第2）；已结题

荣誉奖励
- 2015年度儿童与家庭研究院（已更名为BC省儿童医院研究院）优秀青年研究人员代表。
- 2013-2015 Bertram Hoffmeister 博士后研究基金，BC省儿童医院研究院
- 2008-2010 加拿大安大略省研究与创新部门博士后研究基金
- 2008-2010 加拿大玛嘉烈特公主医院 Michael V. 与 Wanda Plachta 夫妇研究基金
- 2005-2007 加拿大自然科学与工程研究理士会，加拿大博士研究生奖学金

其他事项
专利申请：
(1) P. Chen, H. Yang, S.Y. Fung (2009) Amino acid pairing-based self-assembling peptides and methods. Patent number “WO2009/026729”
(2) P. Chen, M. Jafari, X. Jiang, S.Y. Fung, H. Yang (2011) Peptide sequences and peptide mediated siRNA delivery. Patent number “WO2011/020188”
(3) M. Liu, S.Y. Fung, S. Keshavjee (2012) Compositions comprising self-assembling peptide and amino acid vehicles and active agents pp1 or pp2 and uses thereof. Patent number “WO2012/109732”
海外教学：
- 英属哥伦比亚大学教学, 学习和科技中心, 教学技能培训证书（2013）
- 加拿大英属哥伦比亚大学联合授课：Course of SPPH 563 Technical Aspects of Chemical and Biological Hazard Control: Nanotechnology and Nano-Hazards (Fall 2017)
- 加拿大多伦多大学联合授课：Course of HMB402HIF Bench-to-Bedside: Translating Lab Research into Clinical Practice: Nanotechnology in Acute Lung Injury (Fall 2009, 2010, 2011)