一、基本情况
姓名 | 性别 | 出生年月 |
招生专业 |
| ||
陈棣 | 男 | 195507 | ||||
专业技术职务 |
行政职务 | |||||
教授 | 系主任(美) | 生物化学与分子生物学 | ||||
招生类型 |
所在单位 | |||||
科学学位(博)\科学学位(硕) | 天津医科大学 代谢病医院 | |||||
最后学历及学位 | ||||||
毕业院校 | 毕业时间 | 所学专业 | 所获学位 | |||
美国路易斯维尔大学 | 1992 | 生物化学 | 博士 | |||
| 科学研究主要方向 | |||||
Di_chen@rush.edu | 骨与软骨发育的分子机理 | |||||
二、目前承担科研课题情况
项目名称(级别最高 3-5 项) | 项目来源 | 本人排名 | 本人可支配 经费(万) | 项目起止时间 |
TGF-β-Runx2-Mmp13 通路参与骨关节 炎发病的机制及干预该通路对骨关节 炎的修复作用研究 | 国家自然科学基金面上项目 |
1 |
90 万元 | 2014.1-2017. 12 |
三、发表论文论著情况
题目 | 刊物或出版社 | 本人排名 | 发表时间 | 收录情况 (SCI、EI) |
Anti-DKK1 antibody promotes bone fracture healing through activation of β-catenin signaling. |
Bone |
通讯作者 | 2015 Feb;71:63-75. |
SCI |
Activation of β-catenin signalling leads to temporomandibular joint defects. |
Eur Cell Mater |
通讯作者 | 2014 Oct 23;28:223-35 |
SCI |
TGF-β signaling and the development of osteoarthritis. | Bone Res. | 通讯作者 | 2014;2. pii: 14002. | SCI |
Col2CreER(T2), a mouse model for a chondrocyte-specific and inducible gene deletion. |
Eur Cell Mater |
通讯作者 | 2014 Oct 23;28:236-45 |
SCI |
Carboxyl terminus of Hsp70-interacting protein regulation of osteoclast formation in mice through promotion of tumor necrosis factor receptor-associated factor 6 protein degradation. |
Arthritis & Rheumatology |
通讯作者 |
2014 Jul;66(7):185 4-63. |
SCI |
Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of Rankl/Opg expression and osteoclast formation. |
Arthritis & Rheumatology |
通讯作者 |
2014, 66(1): 107-120 |
SCI |
Chondrocyte-specific inhibition of β-catenin signaling leads to dysplasia of the caudal vertebrae in mice. | Spine (Phila Pa 1976). |
通讯作者 | 2013 Nov 15;38(24):207 9-84 |
SCI |
Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice |
Arthritis Rheum. |
通讯作者 | 2013, 65(12):3107- 19 |
SCI |
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue |
Arthritis Rheum. |
通讯作者 | 2012, 64(8):2611-23 |
SCI |
Conditional activation of β-catenin signaling leads to severe defects in intervertebral disc tissue |
Arthritis Rheum |
通讯作者 |
2012 |
SCI |
Chondrocyte BMP-2 signaling plays a critical role in bone fracture healing | Gene | 通讯作者 | 2012 | SCI |
MMP13 is a critical target gene during the progression of osteoarthritis | Arthritis Res Ther | 通讯作者 | 2012 | SCI |
四、主要业绩