一、 基本情况
| 姓名 | 性别 | 出生年月 |
招生专业 | |||
| 汤华 | 男 | 196302 | ||||
|
专业技术职务 |
行政职务 | |||||
|
教授 | 基础医学院副院长、微生 物学主任、天津市生命科 学中心实验室主任 |
病原生物学（微生物） | ||||
|
招生类型 |
所在单位 | |||||
| 科学学位（博）+ 科学学位（硕） | 基础医学院 | |||||
| 最后学历及学位 | ||||||
| 毕业院校 | 毕业时间 | 所学专业 | 所获学位 | |||
| 天津医科大学 | 1990-7 | 医学微生物学 | 博士 | |||
| | 科学研究主要方向 | |||||
| htang2002@yahoo.com | 肿瘤学，病毒学与分子生物学 | |||||
二、目前承担科研课题情况
| 项目名称（级别最高 3-5 项） | 项目来源 | 本人排名 | 本人可支配 经费（万） | 项目起止时间 |
| 1 .PSMC3 对 Ago2 稳定性的调节及其机 制研究 | 国 家 自 然 科 学 基 金 重 大 研 究 计 划 项 目 | 主持人 | 70 | 2013.01— 2016.12 |
| 2.自凝胶和自释放功能性纳米载体肿 瘤定位持续释放 siRNA 与化疗药物 | 国家自然科学基金 | 主持人 (合作) | 28 | 2014.01-20 17.12 |
| 其他可支配经费 4 项 见附页 | 国家与天津市自然科学基金 | 52 | 2012-2017 | |
| 科研经费合计 | 150 |
三、发表论文论著情况
| 题目 | 刊物或出版社 | 本人排名 | 发表时间 | 收录情况 （SCI、EI） | |
| 1. MicroRNA-10a is involved in the metastatic process by regulating Eph tyrosine kinase receptor A4-mediated epithelial -mesenchymal transition and adhesion in hepatoma cells. |
Hepatology |
通讯作者 |
2013 |
SCI |
11.532 |
| 2. miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) |
J Biol Chem |
通讯作者 |
2013 |
SCI |
4.863 |
| 3. Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth | Cell Death Dis | 通讯作者 | 2014 | SCI | 5.360 |
| 4. miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop. | British Journal of Cancer | 通讯作者 | 2015 | SCI | 5.157 |
| 5. miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells. | Oncotarget | 通讯作者 | 2015 | SCI | 6.402 |
| 6. MiR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian cancer cell lines. | J Cell Biochem | 通讯作者 | 2015 | SCI. | |
| 7. miR-212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells. | IUBMB Life | 通讯作者 | 2015 | SCI. | |
| 8. MiR-23a Facilitates the Replication of HSV-1 through the Suppression of Interferon Regulatory Factor 1 | PLoS One. | 通讯作者 | 2014 | SCI. | |
| 9. MicroRNAs regulate the epithelial to mesenchymal transition (EMT) in cancer progression. | microRNA | 通讯作者 | 2014 | SCI. | |
| 10. Complex interactions between microRNAs and hepatitis B/C viruses | World J Gastroenterol . | 通讯作者 | 2014 | SCI. | |
| 11. MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells | Cancer Lett. | 通讯作者 | 2014 | SCI. 5.122 | |
| 12. DNA Methylation-mediated repression of miR-941 enhances lysine (K)-specific demethylase 6B expression in hepatoma cells | J Biol Chem. | 通讯作者 | 2014 | SCI. 4.863 | |
| 13. Downregulation of PPP2R5E expression by miR-23a suppresses apoptosis to facilitate the growth of gastric cancer cells . | FEBS Lett | 通讯作者 | 2014 | SCI. | |
| 14. NF-κB-modulated miR-130a targets TNF-α in cervical cancer cells | J Transl Med | 通讯作者 | 2014 | SCI. | |
| 15. miR-181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells. | FEBS Lett., | 通讯作者 | 2014 | SCI. | |
| 16. Contribution of hydrophobic/hydrophilic modification on cationic chains of poly (ε -caprolactone)-graft-poly(dimethylamino ethylmethacrylate) amphiphilic co-polymer in gene delivery | Acta Biomaterialia , | 通讯作者 | 2014 | SCI. 5.378 | |
| 17. Downregulation of miR-7 upregulates Cullin 5 (CUL5) to facilitate G1/S transition in human hepatocellular carcinoma cells. | IUBMB Life | 通讯作者 | 2014 | SCI. | |
| 18. Inactivated Sendai virus strain Tianjin, a novel genotype of Sendai virus, inhibits growth of murine colon carcinoma through inducing immune responses and apoptosis | J Transl Med. | 通讯作者 | 2013 | SCI. |
| 19. miR-23a targets interferon regulatory factor 1 and modulates cellular proliferation and paclitaxel-induced apoptosis in gastric adenocarcinoma cells. | PLoS One | 通讯作者 | 2013 | SCI. |
| 20. MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells, | FEBS Lett | 通讯作者 | 2013 | SCI. |
| 21. miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells | Cancer Lett | 通讯作者 | 2013 | SCI. 5.122 |
| 22. MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells | FEBS Lett | 通讯作者 | 2013 | SCI. |
| 23. MiR-17-5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical cancer cells | IUBMB Life. | 通讯作者 | 2012 | SCI. |
| 24. MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cell | Cancer Lett. | 通讯作者 | 2012 | SCI. 5.122 |
| 25. MicroRNA-181b targets cAMP responsive element binding protein 1 in gastric adenocarcinomas | IUBMB life | 通讯作者 | 2012 | SCI. |
| 26. PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53 | FEBS Lett, | 通讯作者 | 2012 | SCI. |
| 27. MiR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells | FEBS Lett | 通讯作者 | 2012 | SCI. |
| 28. MicroRNA-214 Suppresses The Growth and Invasiveness of Cervical Cancer Cells by Targeting UDP-N-acetyl-alpha-D-galactosamine :poly peptide N-acetylgalactosaminyltransferase | J Biol Chem, | 通讯作者 | 2012 | SCI. |
| 29. MicroRNA-182 targets cAMP-responsive element-binding protein suppresses cell growth in human gastric adenocarcinoma. | FEBS J | 通讯作者 | 2012 | SCI. |
四、主要业绩
附页：汤华近 3 年的其他研究经费
| 1. p53—miR-509-5p—Mdm2—p53 反馈 环路影响宫颈癌细胞生长的机制研究 | 国家自然科学基金青年基金 | 23 万元 | 2014-2016 |
| 2.miR-370, miR185 对 HBV 的调控作用 | 国家自然科学基金青年基金 | 13 万元 | 2013-2015 |
| 3. miR-615-5p 对肝癌细胞转移的影响 及其分子机制研究 | 天津市自然科学基金项目 | 6 万元 | 2014-2017 |
| 4.MicroRNA-10a 调控神经胶质瘤生长 及转移的机制研究 | 国家自然科学基金青年基金 | 10 万元 | 2014-2016 |
