一、基本情况
| 姓名 | 性别 | 出生年月 |
招生专业 |
| ||
| 王润玲 | 女 | 195904 | ||||
|
专业技术职务 |
行政职务 | |||||
|
教授 |
药物化学 | |||||
|
招生类型 |
所在单位 | |||||
| 科学学位（博）\科学学位（硕）\专业学位（博）\专业学位（硕） | 天津医科大学药学 院 | |||||
| 最后学历及学位 | ||||||
| 毕业院校 | 毕业时间 | 所学专业 | 所获学位 | |||
| 天津大学 | 2006 | 应用化学 | 博士 | |||
| | 科学研究主要方向 | |||||
| wangrunling@tmu.edu. cn | 计算机辅助药物设计、合成及活性筛选（降糖药及抗癌药） | |||||
二、目前承担科研课题情况
| 项目名称（级别最高 3-5 项） | 项目来源 | 本人排名 | 本人可支配 经费（万） | 项目起止时间 |
| 1 高选择性蛋白酪氨酸磷酸酶 SHP2 抑 制剂的研究 | 国家自然科学基金，** | 主持 |
70 |
2013-2016 |
|
2 精氨酸布洛芬及其糖浆剂研究 |
企业基金 |
主持 |
130 |
2015-2020 |
三、发表论文论著情况
| 题目 | 刊物或出版社 | 本人排名 | 发表时间 | 收录情况 （SCI、EI） |
| Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone， | Drug Design Development and Therapy |
通讯作者 | 2014，8 2255–2262 |
IF 3.026 |
| The Discovery of a Novel and Selective Inhibitor of PTP1B Over TCPTP: 3D QSAR Pharmacophore Modeling, Virtual Screening, Synthesis, andBiological Evaluation |
Chem Biol Drug Des |
通讯作者 |
2014, 83， 697-709 |
IF2.469 |
| SAHA-based novel HDAC inhibitor design by core hopping method | Journal of Molecular Graphics and Modelling | 通讯作者 | 2014,54,10-18 | IF 2.006 |
| The derivatives of oseltamivir design passing through the important cleft of neuraminidase against influenza virus by de novo design | Molecular Simulation | 通讯作者 | 2014, 40(15): 1209–1217 | IF1.137 |
| Design Potential Selective Inhibitors for Treating Cancer by Targeting the Src Homology 2 (SH2) Domain-Containing Phosphatase 2 (Shp2) with Core Hopping Approach | Protein & Peptide Letters | 通讯作者 | 2014, 21(6):556-563 | IF1.493 |
| Designofspeci cinhibitorsoftheproteintyrosinephosphataseSHP-2byv irtualscreening and Corehoppingmethod， | Molecular Simulation | 通讯作者 | 2014，40 （12）:904-91 1 | IF1.137 |
| Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics | Drug Design Development and Therapy | 通讯作者 | 2013:7 ： 279-288 | IF 3.294 |
| DesignandSynthesisofImidazolidine-2,4-Dione Derivativesas Selective Inhibitorsby TargetingProtein Tyrosine Phosphatase-1B Over T-CellProtein Tyrosine Phosphatase， | Chem Biol Drug Des | 通讯作者 | 2013，82 （5）:595-602 | IF 2.469 |
| Design, Synthesis, Biological Activity and Molecular Dynamics Studies of Specific Protein Tyrosine Phosphatase 1B Inhibitors over SHP-2 | Int. J. Mol. Sci. | 通讯作者 | 2013, 14, 12661-12674 | IF 2.4 |
| Agonist and antagonist recognition studies for oestrogen receptor by molecular dynamics Simulation, , | Molecular Simulation | 通讯作者 | 2013, 39(3),228-233 | IF 1.075 |
| Agonist and antagonist recognition studies for oestrogen receptor by moleculardynamics Simulation | Molecular Simulation | 通讯作者 | 2013, 39(3),228-233 | IF 1.0 |
| Scaffold-Based Pan-Agonist Design for the PPAR alpha, PPAR beta and PPAR gamma Receptors.. | PLOS ONE | 通讯作者 | 2012, 7(10), e48453 | IF 4.5 |
| Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach | PLoS ONE， | 通讯作者 | 2012，2012, 7(6), e38546 | IF4.5 |
| Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold. | Bioorganic & Medicinal Chemistry | 通讯作者 | 2012, 20 (19): 5738-5744 | IF 3.1 |
| 1-(2-Hydroxy-3,5-dimethoxyphenyl)- ethanone. | Acta Cryst | 通讯作者 | 2012， E68, o116 | IF0.4 |
| 药物化学 | 清华大学出版社 | 主编 | 2013.7 | |
| 药物化学 | 医药科技出版社 | 主编 | 2012.5 |
四、主要业绩
