姓名：张思河
职称：副教授
一、教育经历
2001.9 – 2004.7第四军医大学细胞生物学博士
1995.9 – 1998.7解放军兽医大学（现吉林大学）遗传学硕士
1991.9 – 1995.7西北农林科技大学遗传学学士
二、工作经历
2011.10-南开大学医学院副教授
2006.9 - 2009.12瑞典隆德大学医院肿瘤科博士后
2005.9 -2011.9 第四军医大学细胞工程研究中心副教授
2000.9 - 2005.8 第四军医大学细胞工程研究中心讲师
1998.9 - 2000.8 第四军医大学细胞生物学教研室助教
三、研究方向
1．研究领域：肿瘤细胞生物学
2．研究方向：（1）细胞内吞机制与靶向药物内化递送,（2）新功能抗体药物研制
3. 承担课题：（1）国家自然科学基金（**, **）,（2）天津市自然科学基金(13JCYBJC21000, 16JCYBJC23900),（3）教育部博士点基金（20**7）
四、学术服务
1. 学会委员：中国细胞生物学学会细胞工程转基因生物分会；中国医药生物技术协会单克隆抗体专业委员；中国抗癌协会肿瘤标志、肿瘤分子医学专业委员会
2. 函评人：国家自然科学基金；教育部博士点基金；天津市自然科学基金
3. 审稿人：INT J ONCOL, ONCOTARGET, EXP CELL RES , ONCOL LETT, ONCOL REP, CANCER MED, EXP THER MED, MOL MED REP
五、近年论文
1．Gao Z, Niu X, Zhang Q, Chen H, Gao A, Qi S, Xiang R, Belting M, Zhang S. Mitochondria chaperone GRP75 moonlighting as a cell cycle controller to derail endocytosis provides an opportunity for nanomicrosphere intracellular delivery. Oncotarget. 2017,8(35):58536-58552.
2．Zhang Q, Zhang W, Li Z, Bai C, Li D, Zheng S, Zhang P, Zhang S. Bacteraemia due to AmpC β-lactamase-producing Escherichia coli in hospitalized cancer patients: risk factors, antibiotic therapy, and outcomes. Diagn Microbiol Infect Dis. 2017, 88(3):247-251.
3．Liu J, Zhang Q, Chen H, Gao Z, Li Y, Sun Z, Xiang R, Zhang S. Phage display library selection of a hypoxia-binding scFv antibody for liver cancer metabolic marker discovery. Oncotarget. 2016, 7(25):38105-38121.
4．Chen H, Gao Z, He C, Xiang R, van Kuppevelt TH, Belting M, Zhang S. GRP75 upregulates clathrin-independent endocytosis through actin cytoskeleton reorganization mediated by the concurrent activation of Cdc42 and RhoA. Exp Cell Res. 2016, 343(2):223-36.
5．Zhang Q, Li D, Bai C, Zhang W, Zheng S, Zhang P*, Zhang S. Clinical prognostic factors for time to positivity in cancer patients with bloodstream infections. Infection. 2016, 44(5):583–588.
6．Zhao P, Zhang W, Wang SJ, Yu XL, Tang J, Huang W, Li Y, Cui HY, Guo YS, Tavernier J, Zhang SH, Jiang JL, Chen ZN. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in HCC cells. Hepatology. 2011,54(6):2012-24.
7. Zhao P, Zhang W, Tang J, Ma XK, Li Y, Jiang JL, Zhang SH, Chen ZN. Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. Cancer Sci.2010,101(2):387–395.
8. Wittrup A, Zhang SH, Belting M，Studies of Proteoglycan Involvement in CPP-Mediated Delivery. Cell-Penetrating Peptides. Methods Mol Biol. 2011;683:99-115.
9. Kong LM, Liao CG, Chen L, Yang HS, Zhang SH, Zhang Z, Bian HJ, Xing JL, ChenZN，Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular carcinoma. J Cell Mol Med. 2011,15(6):1415-28.
10. Wittrup A, Zhang SH, P. Kucharzewska, Johansson M, Welch J, M?rgelin M, Belting M,Magnetic nanoparticle based isolation of endocytic vesicles reveals a functional role of the heat shock protein GRP75 in macromolecular delivery. Proc Natl Acad Sci U S A. 2010，107(30):13342-7.
11. Wittrup A, Zhang SH, ten Dam GB, van Kuppevelt TH, Bengtson P, Johansson M, Welch J, M?rgelin M, Belting M. ScFv antibody-induced translocation of cell-surface heparan sulfate proteoglycan to endocytic vesicles: evidence for heparan sulfate epitope specificity and role of both syndecan and glypican. J Biol Chem. 2009,284(47):32959-67.
六、近年专利
2.6；1.9
七、近年编著
参编《10000个科学难题基础医学篇》，《中国大百科全书第三版》
八、讲授课程
1．研究生：《抗体与疫苗研究进展》，《人类重要疾病概论》
2. 本科生：《医学细胞生物学》，《医学文献检索与利用》
九、联系方式
1．通讯地址：天津市南开区卫津路94号（300071）南开大学医学院306室
2．电话：
3．E-mail：sihezhang@nankai.edu.cn
zsss2005@163.com