姓名：张诗武
职称：主任医师，教授
一、教育经历
1. 1992.09-1997.07天津医科大学临床医学本科（统招）
2. 2000.09-2003.07天津医科大学病理学和病理生理学硕士毕业
3. 2005.09-2008.07天津医科大学肿瘤学博士研究生（统招）
4. 2010.04-2011.03美国M.D.Anderson癌症中心访问副教授
5. 2011.04-2013.01美国M.D.Anderson癌症中心博士后
二、工作经历
1. 1997.07-2002.12天津武警医学院病理教研室助教
2. 2003.01-2005.03天津武警医学院病理教研室讲师
3. 2005.04-2007.12天津医科大学附属肿瘤医院病理科讲师
4. 2007.12-2013.03天津医科大学附属肿瘤医院病理科副教授
5. 2013.03-至今天津人民医院主任医师
三、研究方向（包括承担课题项目）
肿瘤转移分子机制研究
1.c-Myc-Gcn5-HDAC2在调节PGCCs产生红细胞及其成熟过程中的机制，**，201701-202012，国家自然科学基金，57万元；
2.缺氧诱导具有干细胞特性的多倍体巨细胞形成及不对称分裂机制，**，201501-201812，国家自然科学基金，72万元；
3.结直肠癌患者术后转移预测的早期诊断和防治策略，17ZXMFSY00120，201710-202009，天津市科技重大专项，200万元。
四、学术兼职
1.天津市医师协会病理分会常委
2.天津市病理质控中心副主任委员
3.天津医师协会临床精准医疗专业委员会第一届委员会委员
4.中华医学会天津病理学分会第九届委员
5.北京市肿瘤学会病理分会常委
五、近五年发表的学术论文
1.Gao Y, Sun W, Shang W, Li Y, Zhang D, Wang T, Zhang X, Zhang S, Zhang Y, Yang R.Lnc-C/EBPβ Negatively Regulates the Suppressive Function of Myeloid-derived Suppressor Cells. Cancer Immunol Res. 2018 Aug 31. pii: canimm.0108.2018. doi: 10.1158/2326-6066.CIR-18-0108. [Epub ahead of print]
2.Liu G, Wang Y, Fei F, Wang X, Li C, Liu K, Du J, Cao Y, Zhang S. Clinical characteristics and preliminary morphological observation of 47 cases of primary anorectal malignant melanomas. Melanoma research. 2018
3.Liu G, Fei F, Qu J, Wang X, Zhao Y, Li Y, Zhang S. iTRAQ-based proteomic analysis of DMH-induced colorectal cancer in mice reveals the expressions of β-catenin, decorin, septin-7, and S100A10 expression in 53 cases of human hereditary polyposis colorectal cancer. Clinical translational oncology. 2018 Jun 28. doi: 10.1007/s12094-018-1912-6.
4.Li Y, Cong J, Fei F, Zhang Z, Yu Y, Xu C, Zhang S. The use of high-resolution colonic manometry to establish etiology and direct treatment in patients with constipation: case series with correlation to histology. J Gastroenterol Hepatol. 33 (2018) 1864–1872.
5.Zhang S, Fei F, Wang H, Gu Y, Li C, Wang X, Zhao Y, Li Y. Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer. Cancer Science. 2018;109:1825–1833.
6.Wang Y, Zhang S, Xu T, Zhang T, Mo Y, Liu J, Yan L, Xing F. Ultra-sensitive and ultra-fast detection of whole unlabeled livingcancer cell responses to paclitaxel with a graphene-based biosensor. Sensors and Actuators B: Chemical. 2018; 417–425
7.Wang X, Fei F, Qu J, Li C, Li Y, Zhang S. The role of septin 7 in physiology and pathological disease: A systematic review of current status. J Cell Mol Med. 2018;22:3298–3307.
8.Yang Z, Yao H, Fei F, Li Y, Qu J, Li C, Zhang S. Generation of Erythroid Cells from Polyploid Giant Cancer Cells: Re-Thinking about Tumor Blood Supply. Journal of Cancer Research and Clinical Oncology, 144(4), 617-627.
9.Fei Fei, Jie Qu, Chunyuan Li, Xinlu Wang, Yuwei Li and Shiwu Zhang. Role of metastasis-induced protein S100A4 in human non-tumor pathophysiologies. Cell & Bioscience2017;7:64
10.Zhong X, Wang X, Fei F, Zhang M, Ding P, Zhang S.The Molecular Mechanism and Neuroprotective Effect of Dihydrocapsaicin-Induced Mild Hypothermia After Cardiopulmonary Resuscitation in Rats. Ther Hypothermia Temp Manag. Ther Hypothermia Temp Manag. 2018 Jun;8(2):76-82.
11.Li Y, Yu Y, Li S, Zhang M, Zhang Z, Shi Y, Zhang X, Zhang S. iTRAQ-based proteomic analysis reveals the roles of progesterone receptor, inflammatory and fibrosis for slow transit constipation. Journal of Gastroenterology and Hepatology. 2018 Feb;33(2):385-392.
12.Fei F, Jie Qu, Mingqing Zhang, Chunyun Li, Yuwei Li, Shiwu Zhang. S100A4 in cancer progression and metastasis: A systematic review. Oncotarget, 2017,1-20, 2017, Vol. 8, (No. 42), pp: 73219-73239
13.Zhang D, Fei F, Li S, Zhao Y, Yang Z, Qu J, Zhang X, Yin Y, Zhang S. The role of β-catenin in the initiation and metastasis of TA2 mice spontaneous breast cancer. Journal of Cancer. 2017; 8(11): 2114-2123.
14.Wang Y, Zhang C, Zhang S, Zhao Z, Wang J, Song J, Wang Y, Liu J, Hou S. (2017). Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation. Sci Rep. 2017 Apr 28;7(1):1280. doi: 10.1038/s41598-017-01480-2.
15.Tang T, Yang Z, Zhang D, Qu J, Liu G, Zhang S. Clinicopathological study of 9 cases of prostate cancer involving the rectal wall. Diagnostic Pathology. 2017 Jan 17;12(1):8.
16.Zhang D, Yang X, Yang Z, Fei F, Li S, Qu J, Zhang M, Li Y, Zhang X, Zhang S. Daughter Cells and Erythroid Cells Budding from PGCCs and Their Clinicopathological Significances in Colorectal Cancer. J Cancer 2017; 8(3):469-478. doi:10.7150/jca.17012.
17.Zhang S, Zhang D, Yang Z, Zhang X. Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects. Stem Cells Int. 2016;**. Epub 2016 Oct 23.
18.Wang Y, Zhang S, Zhang C, Zhao Z, Zheng X, Xue L, Liu J, Yuan XC. Investigation of an SPR biosensor for determining the influence of connexin 43 expression on the cytotoxicity of cisplatin. Analyst. 2016 May 23;141(11):3411-20
19.Zhang S, Mercado-Uribe I, Sood A, Bast R and Liu J. Coevolution of neoplastic epithelial cells and multilineage stroma via polyploid giant cells during immortalization and transformation of mullerian epithelial cells. Genes & Cancer, 2016 Mar; 7(3-4): 60–72.
20.Yang Y, Liu J, Song F, Zhang S. The clinical diagnostic value of target biopsy using narrow-band imaging endoscopy and accurate laryngeal carcinoma pathologic specimen acquisition. Clin Otolaryngol. Clin Otolaryngol. 2017 Feb;42(1):38-45.
21.Wang Y, Zhang Y, Zhang S, Zhao Z, Min C, Liu J, Yuan X. An optical detection method for analyzing the cellular response to paclitaxel at the single cell level. Anal Methods, 2016, DOI: 10.1039/C6AY00017G
22.Fei F, Zhang D, Yang Z, Wang S, Wang X, Wu Z, Wu Q* and Zhang S. The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer. Journal of Experimental & Clinical Cancer Research. 2015 Dec 24;34(1):158. doi: 10.1186/s13046-015-0277-8.
23.Liu G, Wang H, Yang Z, Tang T, Zhang S. Is It a Metastatic Disease: A Case Report and New Understanding of Rosai-Dorfman Disease? American Journal of Dermatopathology. 2016;38(6):e72-6.
24.Zhang S, Yang C, Yang Z, Zhang D, Ma X, Mills G, Liu Z. Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect. Am J Cancer Res 2015; 5(4):1265-1280.
25.Zhang S, Xu X, Zhu S, Liu J. PGCCs Generating Erythrocytes to Form VM Structure Contributes to Tumor Blood Supply. BioMed Research International.2015, ID 402619.
26.Lv H, Shi Y, Zhang L, Zhang D, Liu G, Yang Z, Li Y, Fei F, Zhang S: Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor. BMC Cancer 2014, 14(1):576.
27.Zhang D, Wang Y, Zhang S. Asymmetric cell division in polyploid giant cancer cells and low eukaryotic cells. BioMed Research International.2014, ID 432652.
28.Zhang L, Ding P, Lv H, Zhang D, Liu G, Yang Z, Li Y, Liu J, Zhang S. Number of polyploid giant cancer cells and expression of EZH2 are associated with VM formation and tumor grade in human ovarian tumor. BioMed Research International.2014, ID 903542.
29.Wang W, Lin P, Sun B, Zhang S, Cai W, Han C, Li L, Lu H, Zhao X. Epithelial-Mesenchymal Transition Regulated by EphA2 Contributes to Vasculogenic Mimicry Formation of Head and Neck Squamous Cell Carcinoma. BioMed Research International. 2014;ID:803914
30.Zhang S, Mercado-Uribe I, Hanash S, Liu J. iTRAQ-based proteomic analysis of distinct protein expression patterns in ovarian polyploid giant cancer cells and their budding daughter cells. Plos one.2013;8(11):e80120.
31.Ren L, Wang X, Dong Z, Liu J, Zhang S. Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway. Med Oncol. 2013; 30:634. DOI 10.1007/s12032-013-0634-4
32.Zhang S, Mercado-Uribe I, Liu J. Tumor stroma and differentiated Cells can be Originated directly from Polyploid Giant Cancer Cells Induced by Paclitaxel. Int J Cancer. 2013 Feb 1;134(3):508-18.
33.Zhang S, Mercado-Uribe I, Sun B, Kuang J, Liu J*. Generation of Cancer Stem-like cells through formation of polyploidy giant cancer cells. Oncogene. 2014;33(1):116-28.
34.Zhang S, Mercado-Uribe I, Liu J*. Generation of erythroid cells by normal and cancer cells in vitro and in vivo. Cancer lett. 2013; 333(2):205-12.
六、荣誉和奖励
1.大肠癌发生与器官特异性转移机制及干预的研究，2006JB-1-007-R3，天津市科技进步一等奖，第三完成人；
2. 双向分化恶性肿瘤血管生成拟态分子机制研究，2004ZR-3-011-R3，天津市自然科学三等奖，第三完成人；
3.多倍体肿瘤巨细胞在肿瘤发生发展过程中的作用及其机制，2016JB-3-084，天津市科技进步三等奖，排名第一；
4.专利：干细胞小球诱导培养液及干细胞小球培养方法，ZL5.**，第一申请人。
七、联系方式
1.通讯地址：天津市红桥区芥园道190号天津市人民医院病理科
2.电话：**
3. E-mail：zhangshiwu666@aliyun.com