姓　　名
薛小松 性　　别
男
出生年月
1983-11 籍　　贯
重庆市南川区
学　　历
博士 毕业院校
南开大学
职　　称
副教授 管理职务

工作内容
教学科研 系所单位
化学系
特殊人才称号
2016年入选天津市“131”创新型人才第三层次
通讯地址
天津市卫津路94号 南开大学 六教318室
电 话
**
电子邮件
xuexs@nankai.edu.cn
课题组网站
http://chem.nankai.edu.cn/dt.aspx?n=A
研究领域
理论与计算有机化学：1）物理有机氟化学；2）化学键能学；3）反应机理研究；4）计算化学。
在研项目：
（1）青年教师及海外留学归国人员研究启动项目，“常见氟源释放氟\三氟甲基过程的基础热力学研究”（主持）2014.1-2015.12
（2）重大项目“C-H 键活化的热力学基础-离子液体中有机化合物的键能和基于化学键能量学的反应机理及溶剂化作用研究”，（参与）2014.01-2018.12。
(3) 国家自然科学基金青年基金，“路易斯酸促进/催化C(sp3)-F键活化机理的理论研究”（主持）2015.1-2017.12
(4) 国家自然科学基金面上项目，“亲电三氟甲硫基化试剂的结构―SCF3基团转移能力关系及反应机理的理论研究”（主持）2018.1-2021.12
招生学科：有机化学。欢迎热爱有机化学、特别是对理论有机化学感兴趣且有志于科研的优秀本科生，研究生加入！

教育及科研经历
薛小松，男，副教授，2013年获南开大学博士学位（师从程津培院士）。2010年8-10月在北京大学余志祥课题组交流学习。2011年6-8月及2012年5-10月在美国Utah State University物理有机化学家Vernon D Parker教授课题组交流访问。2017年9-2019年9月，在美国University of California, Los Angeles 美国科学院院士Ken N Houk教授课题组访问****。研究领域为物理有机化学（理论有机方向），包括：1）物理有机氟化学；2）化学键能学；3）反应机理研究；4）计算化学。
已发表SCI收录学术论文40余篇，其中包括Chem. Rev., J. Am. Chem. Soc.，Angew, Chem., J. Org. Chem.，Org. Lett.等有机化学领域著名期刊。Chemical Science, Org. Lett.，J. Org. Chem.，Org. Biomol.Chem.,Tetrahedron Lett.，J. Fluorine.Chem.等期刊审稿人。 欢迎热爱有机化学、特别是喜欢理论有机化学且有志于科研的优秀本科生，研究生加入！

荣誉和奖励
南开大学优秀博士毕业生

科研成果与代表作
在Chem. Rev., J. Am. Chem. Soc.，J. Org. Chem.，Org. Lett.等有机化学领域著名期刊已发表SCI收录学术论文40余篇,引用800余次：
部分发表文章：
[1] Biying Zhou; Moriana K. Haj; Eric N. Jacobsen; Houk, K. N.,* Xue, Xiao-Song;* Mechanism and Origins of Chemo- and Stereoselectivities of Aryl Iodide-Catalyzed Asymmetric Difluorinations of β-Substituted Styrenes, J. Am. Chem. Soc. 2018. 140, 15206.
[2] Jingjing Zhang; Yang Jin-Dong; Hanliang Zheng; Xue, Xiao-Song;* Herbert Mayr;* Cheng Jin-Pei. Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents, Angew. Chem. Int. Ed. 2018, 57, 12690.
[3] Yang Jin-Dong, Ji Pengju, Xue Xiao-Song, Jin-Pei Cheng* Recent Advances and Advisable Applications of Bond Energetics in Organic Chemistry, J. Am. Chem. Soc. 2018. 140, 8611.
[4] Di Wang, Xiao-Song Xue, Kendall N. Houk,* and Zhuangzhi Shi.* Mild Ring-Opening 1,3-Hydroborations of Non-Activated Cyclopropanes, Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie..
[5] Xue Xiao-Song; Levandowski, Brian J.; Cyndi Qixin He; Houk, K. N.,* Origins of Selectivities in the Stork Diels–Alder Cycloaddition for the Synthesis of (±)-4-Methylenegermine, Org. Lett., 2018. 20, 6108.
[6] Wang, Zhen; Wang, Fang; Xue Xiao-Song;* Ji, Pengju,* Acidity Scale of N-Heterocyclic Carbene Precursors: Can We Predict the Stability of NHC–CO2 Adducts? Org. Lett., 2018. 20, 6041.
[7] Zhu Jiansheng; Zheng Hanliang; Xue, Xiao-Song*; Xiao Yisa; Liu Yafei; Shen Qilong;* Carbon-Selective Difluoromethylation of Soft Carbon Nucleophiles with Difluoromethylated Sulfonium Ylide, Chin. J. Chem.2018. 36, 1069.
[8] Man, Li; Huiying, Kang; Xiao-Song, Xue*; Jin-Pei, Cheng; Computational Study of the Trifluoromethyl Radical Donor Abilities of CF3 Sources, Acta Chim. Sinica 2018. (Invited contribution)
[9] Li, Man; Yueqian Sang; Xue, Xiao-Song;* Cheng, Jin-Pei. Origin of Stereocontrol in Photoredox Organocatalysis of Asymmetric α-Functionalizations of Aldehydes. J. Org. Chem. 2018. 83, 3333.
[10] Zhengwei Guo; Man Li; Xue-Qing Mou; Gang He;* Xiao-Song Xue*; Gong Chen* Radical C–H Arylation of Oxazoles with Aryl Iodides: dppf as an Electron-Transfer Mediator for Cs2CO3. Org. Lett., 2018, 20, 1684.
[11] Wang Zhen; Zheng Yongjun; Zheng Yong; Xue, Xiao-Song;* Ji Pengju * A Systematic Theoretical Study on the Acidities for Cations of Ionic Liquids in Dimethyl Sulfoxide J. Phys. Chem. A 2018, 122, 5750.
[12] Li, Man; Zhen, Hanliang; Xue, Xiao-Song;* Cheng, Jin-Pei. Ordering the relative power of electrophilic fluorinating, trifluoromethylating, and trifluoromethylthiolating reagents: A summary of recent efforts. Tetrahedron Lett. 2018, 59, 1278. (Invited review)
[13] Li, Man; Xue, Xiao-Song;* Cheng, Jin-Pei. Mechanism and Origins of Stereoinduction in Natural Cinchona Alkaloid Catalyzed Asymmetric Electrophilic Trifluoromethylthiolation of β-Ketoesters with N-Trifluoromethylthiophthalimide as Electrophilic SCF3 Source. ACS Catal., 2017, 7, 7977.
[14] Li, Man; Zhou, Biying; Xue, Xiao-Song;* Cheng, Jin-Pei. Establishing the Trifluoromethylthio Radical Donating Abilities of Electrophilic SCF3-Transfer Reagents. J. Org. Chem. 2017. 82, 8697.
[15] Xue, Xiao-Song;# Ji, Pengju,# Zhou, Biying; Cheng, Jin-Pei*. The Essential Role of Bond Energetics in C–H Activation/Functionalization. Chem. Rev. 2017, 117, 8622. (# equally contribution)
[16] Jiang, Shan; Yan, Tai-Shan; Han, Yong-Chao; Cui, Li-Qian; Xue, Xiao-Song;* Zhang, Chi* Hypervalent-Iodine-Mediated Formation of Epoxides from Carbon(sp2)–Carbon(sp3) Single Bonds. J. Org. Chem. 2017, 82, 11691.
[17] Li, Yao; He, Qixin Cyndi; Gao, Fei-Xiang; Li, Zhen; Xue, Xiao-Song; Li, Xin;* Houk, K. N.;* Cheng, Jin-Pei. Design and Applications of N-tert-Butyl Sulfinyl Squaramide Catalysts. Org. Lett. 2017, 19, 1926.
[18] Yang, Jin-Dong; Wang, Ya; Xue, Xiao-Song;* Cheng, Jin-Pei*. A Systematic Evaluation of the N-F Bond Strength of Electrophilic N-F Reagents: Hints for Atomic Fluorine Donating Ability. J. Org. Chem. 2017, 82, 4129.
[19] Li, Man.; Wang, Ya; Xue, Xiao-Song;* Cheng, Jin-Pei. A Systematic Assessment of Trifluoromethyl Radical Donor Abilities of Electrophilic Trifluoromethylating Reagents. Asian J. Org. Chem. 2017. 6, 235.
[20] Zhou, Biying; Xue, Xiao-Song;* Cheng, Jin-Pei. Theoretical study of Lewis acid activation models for hypervalent fluoroiodane reagent: The generality of “F-coordination” activation model. Tetrahedron Lett. 2017, 58,1287.
[21] Zhou, Biying; Yan, Taishan.; Xue, Xiao-Song;* Cheng, Jin-Pei. Mechanism of Silver-Mediated Geminal Difluorination of Styrenes with a Fluoroiodane Reagent: Insights into Lewis-Acid-Activation Model. Org. Lett. 2016, 18, 6128.
[22] Yan, Taishan.; Zhou, Biying; Xue, Xiao-Song;* Cheng, Jin-Pei*. Mechanism and Origin of Unexpected Chemoselectivity in Fluorocyclization of o-Styryl benzamides with a Hypervalent Fluoroiodane Reagent. J. Org. Chem. 2016, 81, 9006.
[23] Li, Man.; Guo, Jinping; Xue, Xiao-Song; * Cheng, Jin-Pei*. Quantitative Scale for the rifluoromethylthio Cation-Donating Ability of Electrophilic Trifluoromethylthiolating Reagents. Org. Lett. 2016, 18, 264.
[24] Li, Man.; Xue, Xiao-Song;* Guo, Jinping; Wang, Ya; Cheng, Jin-Pei*.An Energetic Guide for Estimating Trifluoromethyl Cation Donor Abilities of Electrophilic Trifluoromethylating Reagents: Computations of X–CF3 Bond Heterolytic Dissociation Enthalpies. J. Org. Chem. 2016, 81, 3119.
[25] Xue, Xiao-Song; * Wang, Ya; Man, Li; Cheng, Jin-Pei*. Comprehensive Energetic Scale for Quantitatively Estimating the Fluorinating Potential of N–F Reagents in Electrophilic Fluorinations. J. Org. Chem. 2016, 81, 4280.
[26] Zhang, Panpan; Li , Man; Xue, Xiao-Song; * Xu, Chunfa; Zhao, Qunchao; Liu, Yafei; Wang, HaoYang; Guo, Yinlong; Lu, Long;* Shen, Qilong.* N-Trifluoromethylthiodibenzenesulfonimide: A Shelf-Stable, Broadly Applicable Electrophilic Trifluoromethylthiolating Reagent. J. Org. Chem. 2016, 81, 7486.
[27] Dong, Nan; Zhang, Zhi. Pei; Xue, Xiao-Song; Li, Xin*; Cheng, Jin-Pei. Phosphoric Acid Catalyzed Asymmetric 1,6-Conjugate Addition of Thioacetic Acid to para-Quinone Methides. Angew. Chem. Int. Ed. 2016, 55, 1460.
[28] Xue, Xiao-Song; * Wang, Ya; Chen, Yang; Ji, Pengju, Cheng, Jin-Pei*. Toward Prediction of the Chemistry in Ionic Liquids: An Accurate Computation of Absolute pKa Values of Benzoic Acids and Benzenethiols. J. Org. Chem. 2015, 80, 8997.
[29] Wang, Feng; Yang, Chen.; Xue, Xiao-Song; Li, Xin.; Cheng, Jin-Pei. A Highly Efficient Chirality Switchable Synthesis of Dihydropyran-Fused Benzofurans by Fine-Tuning the Phenolic Proton of β-Isocupreidine (β-ICD) Catalyst with Methyl. Chem. Eur. J. 2015, 21, 10443.
[30] Xue, Xiao-Song; Chen, Yang; Li, Xin;* Cheng, Jin-Pei*. A Computational Study on the pKa Shifts of Proline Induced by Hydrogen-bond Donating Co-catalysts J. Org. Chem. 2014, 79, 1166.
[31] Chen, Yang; Xue, Xiao-Song; Li, Xin;* Cheng, Jin-Pei*. Computational Study on the Acidic Constants of Chiral Br?nsted Acids in Dimethyl Sulfoxide J. Org. Chem. 2014, 79, 4340.
[32] Xue, Xiao-Song; Chen, Yang; Li, Xin; Cheng, Jin-Pei*. Computation of Standard Equilibrium Acidity of C-H Acids in Ionic Media: Shedding Light on Predicting Changes of Chemical Behavior by Switching Solvent System from Molecular to Ionic. Org. Chem. Front. 2014, 1, 176.
[33] Xue, Xiao-Song; Li, Xin; Yu, Ao;* Chen, Yang; Song, Chan; Cheng, Jin-Pei*. Mechanism and Selectivity of Bio-inspired Novel Cinchona Alkaloid Derivatives Catalyzed Asymmetric Olefin Isomerization: A Computational Study. J. Am. Chem. Soc. 2013, 135, 7462.
[34] Yang, Chen; Xue, Xiao-Song; Jin, Jialu; Li, Xin*; Cheng, Jin-Pei*. Theoretical Study on the Acidities of Chiral Phosphoric Acids in Dimethyl Sulfoxide: Hints for Organocatalysis. J. Org. Chem. 2013, 78, 7076.
[35] Li, Xin*; Yang, Chen; Jin, Jialu; Xue, Xiao-Song; Cheng, Jin-Pei*. Synthesis of Optically Enriched Spirocyclic Benzofuran-2-ones via Bifunctional Thiourea Catalyzed Double-Michael Addition of Benzofuran-2-ones to Dienones. Chem. Asian J. 2013, 8, 4.
[36] Li, X;* Liu. Cong; Xue, Xiao-Song; Cheng, Jin-Pei*. Enantioselective Organocatalyzed Sulfenylation of 3-Substituted Oxindoles. Org. Lett. 2012, 4374.
[37] Li, Xin;* Xue, Xiao-Song; Liu, Cong; Wang, Bin; Tan, Boxuan; Jin, Jialu; Zhang, Yueyan; Dong, Nan; Cheng, Jin-Pei*. Asymmetric Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Nitroolefins Catalyzed by a Bifunctional Tertiary-amine thiourea. Org. Biomol. Chem. 2012, 10, 413.
[38] Yu, Ao*; Xue, Xiao-Song; Wang, Jian.; Wang, Huikai.; Wang, Yongjian, The Effects of Insertion of Nitrogen Atoms on the Aromatic Nitrogen-Containing Compounds: a Potential Approach for Designing Stable Radical Molecular Materials. J. Phys. Org. Chem. 2012, 25, 92.
[39] Li, Xin*; Zhang, Yuanyan; Xue, Xiao-Song; Jin, Jialu; Tan, Boxuan; Liu, Cong; Dong, Nan; Cheng, Jin-Pei*. Asymmetric Michael Addition Reactions between 3-Substituted Benzofuran-2(3H)-ones and 1,1-Bis(phenylsulfonyl)ethylene Catalyzed by Bifunctional Catalysts Containing Tertiary Amine and Thiourea Groups. Eur. J. Org. Chem. 2012, 1774.
[40] Xue, Xiao-Song; Yu, Ao;* Cai, Yu; Cheng, Jin-Pei. A Computational Reinvestigation of the Formation of N-Alkylpyrroles via Intermolecular Redox Amination. Org. Lett. 2011, 13, 6054.
[41] Hou, Yanhui;* Wang, Huikai; Li, Zhi; Liu, Yongshen; Wan, Xianjian; Xue, Xiao-Song; Chen, Yongsheng; Yu, Ao. Organic Radicals Based on Phenalenyl and Verdazyl Units. Tetrahedron Lett. 2011, 52, 3670.
[42] Yu, Ao;* Wang, Jijian; Xue, Xiao-Song; Wang, Yongjian*. Theoretical Study of the Peripheral Disulfide Bridge Substituent Effects on the Antioxidant Properties of Naphthyridine Diol Derivatives. J. Phys. Chem. A. 2010, 114, 1008.
[43] Zhang, Huaqiang; Wan, Xianjian; Xue, Xiao-Song; Li, Yanqin; Yu, Ao; Chen, Yongsheng*. Selective Tuning of the HOMO-LUMO Gap of Carbazole-Based Donor-Acceptor-Donor Compounds toward Different Emission Colors. Eur. J. Org. Chem. 2010, 1681.

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