姓　　名
王宝雷 性　　别
男
出生年月
1976-08 籍　　贯
安徽宿县砀山县
学　　历
博士 毕业院校
南开大学
职　　称
副研究员 管理职务

工作内容
教学科研 系所单位
元素有机化学研究所
特殊人才称号

通讯地址
天津市卫津路94号南开大学元素有机化学研究所六教405室
电 话
**
电子邮件
nkwbl@nankai.edu.cn
课题组网站

研究领域
有机化学，农药学

教育及科研经历
2001年获新疆大学有机化学硕士学位，并于同年考入南开大学化学学院元素有机化学研究所攻读农药学专业博士学位，师从李正名院士，2004年7月博士毕业留校任教。2015-2016年受国家公派赴加拿大University of Alberta作访问****，师从Frederick G. West教授进行环状联烯和Nazarov电环化领域的有机合成方法学研究。任教以来，长期担任南开大学本科生《有机化学》和《有机化学实验》课程的教学工作，并在李正名院士课题组从事新农药创制的基础研究工作以及研究生指导和科研管理工作，科研工作主要致力于具有生物活性物质的分子设计、有机合成及构效关系研究。曾主持并完成高等学校博士学科点专项科研基金、天津市应用基础及前沿科技计划项目各1项；曾参加国家“863”计划，“973”计划，中澳国际合作项目，国家自然科学（重点）基金，天津大学/南开大学联合项目，美国DOW化学公司以及Aberjona公司的合作研发项目等多个课题的工作，取得了较好的科研成果。目前主持国家自然科学基金面上项目课题2项，国家重点研发计划子课题1项，天津市自然科学基金课题1项。至今已发表论文50余篇，申请发明专利10项。现为“Chin. Chem. Lett.”杂志青年编委，“J. Agric. Food Chem.”、“Phosphorus Sulfur Silicon Relat. Elem.”、“Chin. J. Chem.”、“有机化学”等杂志审稿人。
荣誉和奖励
2012年，浙江省高校优秀科研成果二等奖
科研成果与代表作
部分发表的文章如下：
[28] Bao-Lei Wang*, Hong-Wei Zhu, Zheng-Ming Li, Li-Zhong Wang, Xiao Zhang, Li-Xia Xiong, Hai-Bin Song. Synthesis, Biological Evaluation and SAR Analysis of Novel Poly Heterocyclic Compounds Containing Pyridylpyrazole Group. Pest Manag. Sci., 2017, DOI: 10.1002/ps.4770.
[27] Bao-Lei Wang*, Li-Yuan Zhang, Xing-Hai Liu, Yi Ma, Yan Zhang, Zheng-Ming Li*, Xiao Zhang. Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2017, https://doi.org/10.1016/j.bmcl.2017.10.065.
[26] Bao-Lei Wang*, Yan Zhang, Xing-Hai Liu, Li-Yuan Zhang, Yi-Zhou Zhan, Xiao Zhang, Li-Zhong Wang, Yong-Hong Li, Zheng-Ming Li*. Synthesis and biological activity of novel dimethylpyrazole and piperazine-containing (bis)1,2,4-triazole derivatives. Phosphorus Sulfur Silicon Relat. Elem., 2017, 192, 34-41.
[25] Bao-Lei Wang, Yan-Xia Shi, Shu-Jun Zhang, Yi Ma, Hong-Xue Wang, Li-Yuan Zhang, Wei Wei, Xing-Hai Liu, Yong-Hong Li, Zheng-Ming Li*, Bao-Ju Li*. Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties. Eur. J. Med. Chem., 2016, 117: 167-178.
[24] Bao-Lei Wang*, Li-Yuan Zhang, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Li-Zhong Wang, Zheng-Ming Li*. Synthesis and biological activities of novel 1,2,4-triazole thiones and bis(1,2,4-triazole thiones) containing phenylpyrazole and piperazine moieties. J. Fluorine Chem., 2016, 184: 36-44.
[23] Yan Zhang, Xing-Hai Liu, Yi-Zhou Zhan, Li-Yuan Zhang, Zheng-Ming Li, Yong-Hong Li, Xiao Zhang, Bao-Lei Wang*. Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2016, 26: 4661-4665.
[22] Bao-Lei Wang*, Yi-Zhou Zhan, Li-Yuan Zhang, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and fungicidal activities of novel 1,2,4-triazole thione derivatives containing 1,2,3-triazole and substituted piperazine moieties. Phosphorus Sulfur Silicon Relat. Elem., 2016, 191: 48-54.
[21] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives. Chin. Chem. Lett., 2016, 27: 163-167.
[20] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Xue-Wen Hua, Ming Liu, Xiao Zhang, Hai-Bin Song, Zheng-Ming Li*. Synthesis and biological activity of novel N-glucosides containing substituted piperazine moiety. Lett. Drug Des. Discov., 2016, 13 (4): 343-351.
[19] Yizhou Zhan, Baolei Wang*, Liyuan Zhang, Yan Zhang, Xiao Zhang, Zhengming Li*, Haibin Song. Studies on the Synthesis, Structure and Biological Activities of Novel Arylaminoformyl-containing 1-Cyano-1-cycloproane Carboxylic Acid Amides Based on Ugi Reaction. Acta Chim. Sinica, 2015, 73, 1173-1181.
[18] Baolei Wang, Yanxia Shi, Yizhou Zhan, Liyuan Zhang, Yan Zhang, Lizhong Wang, Xiao Zhang, Yonghong Li, Zhengming Li*, Baoju Li*. Synthesis and Biological Activity of Novel Furan/Thiophene and Piperazine-Containing (Bis)1,2,4-triazole Mannich Bases. Chin. J. Chem., 2015, 33(10): 1124-1134.
[17] Bao-Lei Wang*, Jing Wu, Qiao-Xia Liu, Yong-Hong Li, Hai-Bin Song, Zheng-Ming Li*. Synthesis, structure, and biological activities of [5-(arylthio/sulfinyl/sulfonyl)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2015, 190(1): 66-78.
[16] Bao-Lei Wang*, Qing-Nan Li, Yi-Zhou Zhan, Li-Xia Xiong, Shu-Jing Yu, Zheng-Ming Li*. The synthesis and biological activities of [5-(4-substituted phenylsulfinyl/sulfonyl)-1,3-dimethyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2014, 189: 483–491.
[15] Bao-Lei Wang, Hong-Wei Zhu, Yi Ma, Li-Xia Xiong, Yong-Qiang Li, Yu Zhao, Ji-Feng Zhang, You-Wei Chen, Sha Zhou, Zheng-Ming Li*. Synthesis, Insecticidal Activities, and SAR Studies of Novel Pyridylpyrazole Acid Derivatives Based on Amide Bridge Modification of Anthranilic Diamide Insecticides. J. Agric. Food Chem., 2013, 61: 5483-5493.
[14] Zhang, Ji-Feng ; Liu, Chen; Ma, Yi; Wang, Bao-Lei*; Xiong, Li-Xia; Yu, Shu-Jing; Li, Zheng-Ming*. Synthesis of Novel 3-Chloropyridin-2-yl-Pyrazole Derivatives and their Insecticidal, Fungicidal Activities and QSAR Study. LETTERS IN DRUG DESIGN & DISCOVERY, 2013, 10(6): 497-506.
[13] Wang Baolei, Ma Yi, Xiong Lixia, Li Zhengming. Synthesis and Insecticidal Activity of Novel N-Pyridylpyrazole Carbonyl Thioureas. Chin. J. Chem., 2012, 30: 815-821.
[12] Ji-Feng Zhang, Jun-Ying Xu, Bao-Lei Wang, Yu-Xin Li, Li-Xia Xiong, Yong-Qiang Li, Yi Ma, Zheng-Ming Li. Synthesis and Insecticidal Activities of Novel Anthranilic Diamides Containing Acylthiourea and Acylurea. J. Agric. Food Chem., 2012, 60: 7565-7572.
[11] Wang Bao-Lei, Liu Xing-Hai, Zhang Xiu-Lan, Zhang Ji-Feng, Song Hai-Bin, Li Zheng-Ming*. Synthesis, Structure and Biological Activity of Novel 1,2,4-Triazole Mannich Bases Containing a Substituted Benzylpiperazine Moiety. Chem. Biol. Drug Des., 2011, 78: 42-49.
[10] Wang, Bao-Lei; Shi, Yan-Xia; Ma, Yi; Liu, Xing-Hai; Li, Yong-Hong; Song, Hai-Bin; Li, Bao-Ju*; Li, Zheng-Ming*. Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings. Journal of Agricultural and Food Chemistry 2010, 58(9): 5515-5522.
[9] Wang, B. L.; Ma, R. D.; Li, Y. H.; Song, H. B.; Li, Z. M. Synthesis, Structure and Biological Activity of 2- 4-(5-Substituted-1,3,4-oxadiazol-2-yl)phenoxy Propanoate/Acetate. Chinese Journal of Organic Chemistry 2010, 30(1): 92-97.
[8] Wang, B. L.; Liu, X. H.; Li, Z. M., Synthesis and Characterization of O,O-Dimethyl-N-(2,2,2-trichloro- 1-arylaminoethyl) Phosphoramidothioates. Phosphorus Sulfur and Silicon and the Related Elements 2009, 184(9): 2281-2287.
[7] Bao-Lei Wang, Yong-Hong Li, Jian-Guo Wang, Yi Ma, Zheng-Ming Li. Molecular design, synthesis and biological activities of amidines as new ketol-acid reductoisomerase inhibitors. Chin. Chem. Letts., 2008, 19: 651-654.
[6] WANG Bao-Lei, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Synthesis and Herbicidal Activities of 4-Alkoxy/benzyloxyphenyltetrazoles and 1,3,4-Oxadiazoles. Chem. J. Chin. U., 2008, 29(1): 90-94.
[5] Bao-Lei Wang, Zheng-Ming Li, Yong-Hong Li, Su-Hua Wang. Syntheses and biological activities of ethyl N-hydroxy-N-(substituted)phenyloxamates as KARI inhibitors. Chem. Res. Chin. U., 2007, 23(3): 280-283.
[4] Bao-Lei Wang, Ronald G Duggleby, Zheng-Ming Li, Jian-Guo Wang, Yong-Hong Li, Su-Hua Wang, Hai-Bin Song.
Synthesis, crystal structure and hebricidal activity of mimics of intermediates of the KARI reaction. Pest Management Science, 2005, 61: 407-412.
[3] WANG Bao-Lei, WANG Jian-Guo, MA Yi, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Molecular Docking and 3D-QSAR Research of Amidines of KARI Inhibitor. Acta Chimica Sinica, 2006, 64(13): 1373-1378.
[2] WANG Bao-Lei, LI Zheng-Ming, MA Yi, WANG Jian-Guo, LUO Xiao-Min, ZUO Zhi-Li. 3D-Database Searching Based on the Crystal Structure of Ketol-acid Reductoisomerase (KARI) Complex. Chin. J. Org. Chem., 2004, 24(8): 973-976.
[1] Wang Bao-Lei, Ma Ning, Wang Jian-Guo, Ma Yi, Li Zheng-Ming, Li Yong-Hong. 3D-QSAR Analysis of New Sulfonylureas Related to Their Herbicidal Activity. Acta Physico-chimica Sinica, 2004, 20(6): 577-581.
部分授权专利如下：
[2] 王宝雷, 李正名, 张燕, 张丽媛, 张晓, 李永红. 含哌嗪的1,3,4-噁二唑Mannich碱类化合物及制备与应用. 中国发明专利, 申请号: 2.X, 申请日: 2016年01月20日; 公开号: CN A, 公开日: 2016年05月04日; 授权号: ZL 2.X, 授权日: 2017年09月12日.
[1] 李正名, 王宝雷, 张吉凤, 徐俊英, 熊丽霞, 赵毓, 王刚. 吡唑甲酰基硫脲衍生物与制备方法和应用. 中国发明专利, 申请号: 5.7, 申请日: 2011年06月02日; 公开号: CN A, 公开日: 2011年12月14日; 授权号: ZL 5.7, 授权日: 2013年11月06日.

人才培养
指导硕士生，并协助李正名院士指导硕博士生，已毕业13人。