姓　　名
刘定斌 性　　别
男
出生年月
1983-11 籍　　贯
贵州省修文县
学　　历
博士 毕业院校
中国科学院
职　　称
研究员 管理职务
中心副主任
工作内容
教学科研 系所单位
分析科学研究中心
特殊人才称号
国家四青人才
通讯地址
南开大学中心实验室B313
电 话

电子邮件
liudb@nankai.edu.cn
课题组网站
http://liulab.sklmcb.nankai.edu.cn/
研究领域
1.利用先进的分离富集技术进行肿瘤标志物筛选
2.发展高灵敏、高特异性的肿瘤影像探针
3.建立面向临床转化的体外诊断新方法
招生学科：分析化学

教育及科研经历
2002-2006 兰州大学 学士
2006-2009 中科院成都生物所 硕士
2009-2012 国家纳米科学中心 博士
2012-2014 美国国立卫生研究院 博士后
2014 至今 南开大学化学学院 研究员/博导


荣誉和奖励
2019 中华医学会青年科技奖
2019-至今 《高等学校化学学报》青年编委
2018-至今 中国生物医学工程协会青年委员
2018-至今 中国抗癌协会青年委员
2017-至今 Nanotheranostics副主编/编委

科研成果与代表作
近年来，已在生物医学检测和临床诊断领域发表论文60余篇，其中第一或通讯作者论文45篇，包括1篇Chem. Rev.（IF 54.301），4篇ACS Nano（IF 13.903），4篇Angew. Chem. Int. Ed.（IF 12.257），和14篇Anal. Chem.（IF 6.35）等。论文的他引次数达到3500余次，已获授权中国专利7项，美国专利1项，并实现部分专利的成果转化。以项目主持人获批国家级项目6项（包括国家QNQR计划项目、国家重点研发计划课题1项、国家自然科学基金面上项目3项、国家自然科学基金青年项目1项）和省部级项目1项（天津市科委重点项目），总经费达900余万元。荣获中华医学会青年科技奖，担任国际医学杂志Nanotheranostics副主编和《高校化学学报》青年编委。
近期发表论文如下：
(1) Cai Zhang, Xiaoyu Cui, Jie Yang, Xueguang Shao, Yuying Zhang, Dingbin Liu*. Stimulus-responsive surface-enhanced Raman scattering: a “Trojan horse” strategy for precision molecular diagnosis of cancer. Chemical Science, 2020, DOI: 10.1039/D0SC01649G (Front Cover).
(2) Cai Zhang, Zhiwen Xu, Huixia Di, Erzao, Zeng, Ying Jiang, Dingbin Liu*. Gadolinium-Doped Prussian Blue Nanoparticle as a Theranostic Agent for Dendritic Cell Activating and Tracking. Theranostics, 2020, 10, 6061-6071.
(3) Ying Jiang, Lei Wang, Pengjuan Zhang, Xuehui Liu, Huixia Di, Jie Yang, Shu-Lin Liu, Dai-Wen Pang, Dingbin Liu*. Chemoenzymatic Labeling of Extracellular Vesicles for Visualizing Their Cellular Internalization in Real Time. Analytical Chemistry 2020, 92, 2103-2111.
(4) Qiang Li, Fengchao Wang, Jie Yang,* Dingbin Liu*. Direct cytoplasm delivery of gold nanoparticles for real-time apoptosis detection. Nano Research, 2020, 13, 853-860.
(5) Shuxin Song, Jingyu Wang, Na Song, Huixia Di, Dingbin Liu, Zhilin Yu*. Peptide interdigitation-induced twisted nanoribbons as chiral scaffolds for supramolecular nanozymes. Nanoscale, 2020, 12, 2422-2433.
(6) Wenshuai Li, Guorui Wu, Xijing Zhang, Aiqin Yue, Weijun Du, Jinzhong Zhao,* Dingbin Liu* Advances in Bacterial Detection Based on Raman Spectroscopy. Chemical Journal of Chinese Universities, 2020, 41, 872-883.
(7) Bo Dong, Shuangli Du, Chunxiao Wang, Haohao Fu, Qiang Li, Nannan Xiao, Jie Yang, Xue Xue, Weisheng Cai, Dingbin Liu*. Reversible Self-Assembly of Nanoprobes in Live Cells for Dynamic Intracellular pH Imaging. ACS Nano, 2019, 13, 1421-1432.
(8) Pengjuan Zhang, Haohao Fu, Shuangli Du, Fengchao Wang, Jie Yang, Wensheng Cai,* Dingbin Liu*. Click-RNA for Rapid Capture and Identification of Intracellular MicroRNA Targets. Analytical Chemistry, 2019, 91, 15740-15747.
(9) Xuehui Liu, Xiaoman Liu, Pengfei Rong,* Dingbin Liu*, Recent Advances in Background-Free Raman Scattering for Bioanalysis. Trends in Analytical Chemistry, 2019, 123, 115765.
(10) Qiang Li, Xinkai Qiao, Fengchao Wang, Xuejing Li, Yang Liu, Linqi Shi, Dingbin Liu*. Encapsulating a Single Nanoprobe in a Multifunctional Nanogel for High-Fidelity Imaging of Caspase Activity in Vivo. Analytical Chemistry, 2019, 91, 13633-13638.
(11) Huixia Di, Erzao Zeng, Pengjuan Zhang, Xuehui Liu, Cai Zhang, Jie Yang, Dingbin Liu*. General Approach to Engineering Extracellular Vesicles for Biomedical Analysis. Analytical Chemistry, 2019, 91, 12752-12759.
(12) Ji Qi, Jun Li, Ruihua Liu, Qiang Li, Haoke Zhang, Jacky W. Y. Lam, Tyan T. k. Kwok, Dingbin Liu, Dan Ding* and Benzhong Tang*. Boosting Fluorescence-Photoacoustic-Raman Properties in One Fluorophore for Precise Cancer Surgery. Chem, 2019, 5, 2657-2677.
(13) Xuejing Li, Erzao Zeng, Huixia Di, Qiang Li, Jingwei Ji, Jie Yang*, Dingbin Liu*. When Prussian Blue Meets Porous Gold Nanoparticles: A High Signal-to-Background Surface-Enhanced Raman Scattering Probe for Cellular Biomarker Imaging. Advanced Biosystems, 2019, 3, **.
(14) Yang Deng, Dianqi Li, Xingming Ning, Dongxu Zhang, Shouting Zhang, Zhen Zhang, Duoliang Shan, Zhenyu Wang, Dingbin Liu, Xiang Mao*, Xiaoquan Lu*. Self-Assembly of Biocompatible FeSe Hollow Nanostructures and 2D CuFeSe Nanosheets with One- and Two-Photon Luminescence Properties. Small, 2019, 15, **.
(15) Dianqi Li, Fengchao Wang, Huixia Di, Xuehui Liu, Pengjuan Zhang, Wen Zhou, Dingbin Liu*. Cross-Linked Polyethylene Glycol Shells for Nanoparticles: Enhanced Stealth Effect and Colloidal Stability. Langmuir, 2019, 35, 8799-8805.
(16) Yang Xue, Bo Dong, Xuehui Liu, Fengchao Wang, Jie Yang, Dingbin Liu*. Using Selenium-conjugated Polyethylene Glycol to Enhance the Stability of Gold Nanoparticles in Biologically Relevant Samples. Science China Chemistry, 2019, 62, 280-286.
(17) Penguan Zhang, Jie Yang,* Dingbin Liu*. Two-step Signal Amplification for High-Sensitivity Detection of Biomarkers using Gold Nanoparticle-based Conjugates. Electrophoresis, 2019, 40, 2211-2217.
(18) Mingmin Li, Jianzhen Wu, Mengtian Ma, Zhichao Feng, Ze Mi, Pengfei Rong,* Dingbin Liu*. Alkyne- and Nitrile-Anchored Gold Nanoparticles for Multiplex SERS Imaging of Biomarkers in Cancer Cells and Tissues. Nanotheranostics, 2019, 3, 113-119.
(19) Fengchao Wang, Qiang Li, Penguan Zhang, Xuehui Liu, Ang Li, Jie Yang, Dingbin Liu*. Assembly of DNA Probes into Superstructures for Dramatically Enhancing Enzymatic Stability and Signal-to-Background Ratio. ACS Sensors, 2018, 3, 2702-2708.
(20) Penguan Zhang, Bo Dong, Erzao Zeng, Fengchao Wang, Ying Jiang, Dianqi Li, Dingbin Liu*. In Vivo Tracking of Multiple Tumor Exosomes Labeled by Phospholipid-Based Bioorthogonal Conjugation. Analytical Chemistry, 2018, 90, 11273-11279.
(21) Xia Gao, Qiang Li, Fengchao Wang, Xuehui Liu, Dingbin Liu*. Dual-Responsive Self-Assembled Monolayer for Specific Capture and On-Demand Release of Live Cells. Langmuir, 2018, 34, 8145-8153.
(22) Jin Li, Huiqiao Liu, Pengfei Rong, Wen Zhou, Xiaohu Gao, Dingbin Liu*. A Universal Strategy for One-pot Synthesis of SERS Tags. Nanoscale, 2018, 10, 8292-8297.
(23) Wen Zhou, Qiang Li, Huiqiao Liu, Jie Yang, Dingbin Liu*. Building Electromagnetic Hot Spots in Living Cells via Target-Triggered Nanoparticle Dimerization. ACS Nano, 2017, 11, 3532-3541.
(24) Sisi Ma, Qiang Li, Yongmei Yin, Jie Yang, Dingbin Liu*. Interference-Free Surface‐Enhanced Raman Scattering Tags for Single‐Cell Molecular Imaging with a High Signal‐to‐Background Ratio. Small, 2017, 13, **.
(25) Huixia Di, Huiqiao Liu, Mingmin Li, Jin Li, Dingbin Liu*. High-Precision Profiling of Sialic Acid Expression in Cancer Cells and Tissues Using Background-Free SERS Tags. Analytical Chemistry, 2017, 89, 5874-5881.
(26) Huiqiao Liu, Qiang Li, Mingmin Li, Sisi Ma, Dingbin Liu*. In-Situ Hot-Spot Assembly as a General Strategy for Probing Single Biomolecules. Analytical Chemistry, 2017, 89, 4776-4780.
(27) Mingmin Li, Jin Li, Huixia Di, Huiqiao Liu, Dingbin Liu*. Live-Cell Pyrophosphate Imaging by In-Situ Hot-Spot Generation. Analytical Chemistry, 2017, 89, 3532-3537.
(28) Dingbin Liu*, Xiaoyuan Chen*. An Ultrasensitive Biosensing Platform Employing Acetylcholinesterase and Gold Nanoparticles. Cancer Nanotechnology: Methods and Protocols, 2017: 307-316.
(29) Yongmei Yin, Qiang Li, Sisi Ma, Huiqiao Liu, Bo Dong, Jie Yang, Dingbin Liu*. Prussian Blue as a Highly Sensitive and Background-Free Resonant Raman Reporter. Analytical Chemistry, 2017, 89, 1551-1557.
(30) Yanmei Xiong, Mingmin Li, Huiqiao Liu, Zhihong Xuan, Jie Yang*, Dingbin Liu*. Janus PEGylated Gold Nanoparticle: A Robust Colorimetric Probe for Sensing Nitrite Ions in Complex Samples. Nanoscale, 2017, 9, 1811-1815.
(31) Yuyan Zhang, Wen Zhou, Yang Xue, Jie Yang, Dingbin Liu*. Multiplexed Imaging of Trace Residues in a Single Latent Fingerprint. Analytical Chemistry, 2016, 88, 12502-12507.
(32) Zhihong Xuan, Mingmin Li, Pengfei Rong, Wei Wang, Yijun Li*, Dingbin Liu*. Plasmonic ELISA based on the controlled growth of silver nanoparticles. Nanoscale, 2016, 8, 17271-17277.
(33) Fangfei Yin, Huiqiao Liu, Qiang Li, Xia Gao, Yongmei Yin, Dingbin Liu*. Trace MicroRNA Quantification by Means of Plasmon-Enhanced Hybridization Chain Reaction. Analytical Chemistry, 2016, 88, 4600-4604.
(34) Huiqiao Liu, Pengfei Rong, Hongwei Jia, Jie Yang, Bo Dong, Qiong Dong, Cejun Yang, Pengzhi Hu, Wei Wang, Haitao Liu, Dingbin Liu*, Wash-Free Homogeneous Colorimetric Immunoassay Method. Theranostics, 2016, 6, 54-64.
(35) Wen Zhou, Xia Gao, Dingbin Liu*, and Xiaoyuan Chen*, Gold nanoparticles for in vitro diagnostics. Chemical Reviews, 2015, 115, 10575-10636.
(36) Shouju Wang , Zhaogang Teng, Peng Huang, Dingbin Liu, Ying Liu, Ying Tian, Jing Sun, Yanjun Li, Huangxian Ju, Xiaoyuan Chen, and Guangming Lu*. Reversibly Extracellular pH Controlled Cellular Uptake and Photothermal Therapy by PEGylated Mixed‐Charge Gold Nanostars. Small, 2015, 11, 1801-1810.
(37) Yanmei Xiong, Yuyan Zhang, Pengfei Rong, Jie Yang, Wei Wang, Dingbin Liu*, A high-throughput colorimetric assay for glucose detection based on glucose oxidase-catalyzed enlargement of gold nanoparticles. Nanoscale, 2015, 7, 15584-15588.
(38) Dingbin Liu*, Jie Yang, He-Fang Wang, Zhongliang Wang*, Xinglu Huang, Zhantong Wang, Gang Niu, A. R. Hight Walker, and Xiaoyuan Chen*, Glucose Oxidase-Catalyzed Growth of Gold Nanoparticles Enables Quantitative Detection of Attomolar Cancer Biomarkers. Analytical Chemistry, 2014, 86, 5800-5806.

人才培养
已培养博士后2名，博士生5名，硕士生7名。
本课题组每年拟招收1-2名博士生，1-2名硕士生。