姓名：赵炜

性别：男

职称：副教授

学科方向：糖化学与化学生物学

招生方向：药物化学（糖化学，化学生物学）

通讯地址：南开大学药学院 天津市卫津路94号 300071

实验室：南开大学天南大联合大厦D座604室

电话：**

传真：**

电子邮件：wzhao@nankai.edu.cn

教育背景与工作经历

有机化学博士。1999年7月于山东大学化学院获化学学士学位；2005年4月于中国科学院生态环境研究中心获环境化学博士学位（师承孔繁祚研究员）。 2005年3月进入清华大学化学系从事博士后研究工作，从事糖肽的合成及免疫学性质研究，2007年5月出站。2007年6月加入南开大学药学院。2009-2010年在美国俄亥俄州立大学化学与生物化学系作访问学者，并在美国国立卫生院（NIH）做交流访问。主持或参加过多项国家自然科学基金重点及面上项目、天津市科技支撑重点项目和面上项目及科技部973课题的研究。

研究方向：糖化学与糖药物学

（1）复杂寡糖化学-酶法合成策略的探索；

（2）抗肿瘤糖疫苗的合成及免疫学评价；

（3）抗凝血药物肝素五糖的化学改造；

（4）糖苷酶、糖基转移酶抑制剂等糖类新药的发现。

承担课程：药物化学，药学综合实验（本科生）与科技论文写作（研究生）
科研论文摘录

12. Wenjun Wang, Zhongyue Yang, Yun Xu, Taibao Liu, Tianbang Song, Yunyan Zhao, Xiufang Xu*, Wei Zhao* and Peng George Wang*, ““Armed and disarmed” theory in the addition of an azide radical to glucals”, RSC Advances, 2015, 5 , 38577 - 38580.

11. Tiehai Li, Lina Guo, Yan Zhang, Jianping Lin, Jiajia Wang, Zhenxing Zhang, Jing Li, Wenpeng Zhang, Wei Zhao^* and Peng George Wang ^*.. “Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors”. Bioorganic & Medicinal Chemistry. 19 (2011) 2136–2144.

10. Lina Guo, Taibao Liu, Kai Chen, Tianbang Song, Peng George Wang* and Wei Zhao*, “Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor”, Organic & Biomolecular Chemistry, 2014, 12, 7310–7317.

9. Tiehai Li, Hui Ye, Xuefeng Cao, Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen^*, Wei Zhao^*, and Peng Wang^*, “Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux”. ChemMedChem 2014, 9, 1071 – 1080.

8. Yi, Wen; Liu, Xianwei; Xia, Chengfeng; Zhao, Wei; Zhang, Wenpeng; Chen, Xi; Wang, Peng G. “Remodeling Bacterial Polysaccharides by Metabolic Pathway Engineering” Proceedings of the National Academy of Sciences, 2009, 106(11), 4207-4212.

7. Lei Li, Yonghui Liu, Yue Wan, Yanhong Li, Xi Chen, Wei Zhao^*, and Peng George Wang^*,“Efficient Enzymatic Synthesis of Guanosine 5’-diphosphate-Sugars and Derivatives”. Organic letters. 2013, 21, 5528–5530.

6. Cai, Li; Guan, Wanyi; Wang, Wenjun; Zhao, Wei; Kitaoka, Motomitsu; Shen, Jie; O'Neil, Crystal; Wang, Peng George. “Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives.” Bioorganic & Medicinal Chemistry Letters 2009, 19, 5433-5435.

5. Lina Guo, Yonghui Liu, Yue Wan, Peng George Wang and Wei Zhao*,“Effective and one-step stereo-controlled synthesis of polybenzyloxylateddiiodopentanes for the synthesis of five-membered imino-sugars”. Tetrahedron Letters. 2013, 54，2579-2582.

4. Tiehai Li, Zhonghua Li, Jing Li, Jiajia Wang, Lina Guo, Peng George Wang^*, Wei Zhao*, “Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.” Bioorganic & Medicinal Chemistry Letters. 22 (2012) 6854-6857.

3. Lei Li, Yonghui Liu, Wenjun Wang, Jiansong Cheng, Wei Zhao*, and Peng Wang^*. “A Highly Efficient Galactokinase from Bifidobacterium infantis with Broad Substrate Specificity.” Carbohydrate Research, 2012, 355C, 34-38.

2. Lina Guo, Yue Wan, Xin Wang, Peng George Wang, Wei Zhao*,“Development of Aminoglycoside Antibiotics by Carbohydrate Chemistry.”Mini-Reviews in Medicinal Chemistry. 2012, 12, 1533-1541.

1. Wenjun Wang, Chen Jin, Lina Guo, Yu Liu, Yue Wan, Xin Wang, Lei Li, Wei Zhao*, Peng George Wang^*,“Preparation of oligosaccharides by homogenous enzymatic synthesis and solid phase extraction.” Chemical Communications, 2011, 47, 11240-11242.

撰写著作

Wei Zhao, Tiehai Li, Robert Woodward, Chengfeng Xia, Peng George Wang and Wanyi Guan. “Enzymatic Synthesis of Complex Carbohydrates”. Comprehensive Natural Products Chemistry II. Volume 6. Elsevier 2010, 5-54.