人才师资
邓新
学历： 博士
职称： 教授
专业方向： 微生物遗传
招生专业： 微生物学、生物化学与分子生物学
人员简介：
邓新，博士，教授。


1997-2001 中国农业大学，学士
2001-2004中国农业大学，硕士
2004-2009美国堪萨斯州立大学，博士
2010-2015美国芝加哥大学，博士后
2015- 南开大学，教授


十年多来，一直系统地从事病原细菌的致病机制和分子调控机制研究，取得了一系列具有国际前沿水平的创新成果。共在Cell Host & Microbe, Nucleic Acids Research, Molecular Plant-Microbe Interactions, Journal of Bacteriology等国际权威期刊发表SCI收录论文近30篇，被引用400余次。现任十余个国际著名杂志的专业审稿人，参加十余次国际会议。

E-mail: dengxindx@gmail.com

代表论文：

1. Deng X*, Liang H*, Chen, K, He C, Lan L, Tang X. (2014). Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae. Nucleic Acids Res. 42(18):11472-86. (* contributed equally).
2. Liang H*, Deng X*, Li X, Ye Y, Wu M. (2014). Molecular mechanisms of master regulator VqsM mediating quorum-sensing and antibiotic resistance in Pseudomonas aeruginosa. Nucleic Acids Res. 42 (16): 10307-10320. (* contributed equally).
3. Deng X, Liang H, Ulanovskaya O, Ji Q, Zhou T, Sun F, Lu Z, Hutchison A, Lan L, Wu M, Cravatt B, He C. (2014). Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa. J Bacteriol. 196(14):2499-2513.
4. Deng X, Weerapana E, Ulanovskaya O, Sun F, Liang H, Ji Q, Ye Y, Fu Y, Zhou L, Li J, Zhang H, Wang C, Alvarez S, Hicks ML, Lan L, Wu M, Cravatt B, He C. (2013). Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host & Microbe 13 (3): 358-70.
5. Liang H*, Deng X*, Ji Q, Sun F, Shen T, He C. (2012). Regulatory mechanism of global regulator VqsR to quorum-sensing systems and virulence factors in Pseudomonas aeruginosa. J Bacteriol. 194(12):3098-108 (* contributed equally).
6. Deng X, Sun F, Ji Q, Liang H, Missiakas D, Lan L, He C. (2012). Expression of multidrug resistance efflux pump gene norA is iron-responsive in Staphylococcus aureus. J Bacteriol. 194(7):1753-62.
7. Deng X, Lan L, Kennelly M, Zhou JM, Tang X. (2010). Pseudomonas syringae two-component response regulator RhpR regulates genes under an inverted repeat element promoter. Mol Plant Microbe Interact. 23(7):927-39.
8. Deng X, Lan L, Xiao Y, Zhou JM, Tang X. (2009). Pseudomonas syringae pv. phaseolicola mutants compromising type III secretion system. Mol Plant Microbe Interact. 22(8):964-76.
9. Ding Y, Liu X, Chen F, Di H, Xu B, Zhou L, Deng X, Wu M, Yang CG, Lan L. Metabolic sensor governing bacterial virulence in Staphylococcus aureus. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4981-90. doi: 10.1073/pnas.**. Epub 2014 Nov 3.
10. Cao Q, Wang Y, Chen F, Xia Y, Lou J, Zhang X, Yang N, Sun X, Zhang Q, Zhuo C, Huang X, Deng X, Yang CG, Ye Y, Zhao J, Wu M, Lan L. (2014) A novel signal transduction pathway that modulates rhl quorum sensing and bacterial virulence in Pseudomonas aeruginosa. PLoS Pathog. 2014;10(8):e**. doi: 10.1371/journal.ppat.**.
11. Yu P, Yuan J, Deng X, Ma M, Zhang H. (2014) Subcellular targeting of bacterial CusF enhances Cu accumulation and alters root to shoot Cu translocation in Arabidopsis. Plant Cell Physiol. 55 (9): 1568-1581.
12. Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C. (2014). A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 10:93-95.
13. Ji Q, Zhang L, Jones MB, Sun F, Deng X, Liang H, Cho H, Brugarolas P, Gao NY, Peterson NS, Lan L, Bae T, He C. (2013). Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc Natl Acad Sci U S A. 110(13):5010-5.
14. Liang H, Deng X, Bosscher M, Ji Q, Jensen MP, He C. (2013). Engineering bacterial two-component system PmrA/PmrB to sense lanthanide ions. J Am Chem Soc. 135(6):2037-9.
15. Sun F, Ding Y, Ji Q, Liang Z, Deng X, Wong CC, Yi C, Zhang L, Xie S, Alvarez S, Hicks LM, Luo C, Jiang H, Lan L, He C. (2012). Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A. 109(38):15461-6.
16. Sun F, Liang H, Kong X, Xie S, Cho H, Deng X, Ji Q, Zhang H, Alvarez S, Hicks LM, Bae T, Luo C, Jiang H, He C. (2012). Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci U S A. 109(23):9095-100.
17. Ji Q, Zhang L, Sun F, Deng X, Liang H, Bae T, He C. (2012). Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response. J Biol Chem. 287(25):21102-9.
18. Qian Y, Zhang L, Ding S, Deng X, He C, Zheng EX, Zhu HL, Zhao J. (2012). A fluorescent probe for rapid detection of hydrogen sulfide in blood plasma and brain tissues in mice. Chem. Sci. 3:2920-2923.
19. Sun F, Ji Q, Jones MB, Deng X, Liang H, Frank B, Telser J, Peterson SN, Bae T, He C. (2012). AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus. J Am Chem Soc. 134(1):305-14.
20. Sun F, Zhou L, Zhao BC, Deng X, Cho H, Yi C, Jian X, Song CX, Luan CH, Bae T, Li Z, He C. (2011). Targeting MgrA-mediated virulence regulation in Staphylococcus aureus. Chem Biol. 18(8):1032-41.
21. Lan L, Deng X, Xiao Y, Zhou JM, Tang X. (2007). Mutation of Lon protease differentially affects the expression of Pseudomonas syringae type III secretion system genes in rich and minimal media and reduces pathogenicity. Mol Plant Microbe Interact. 20(6):682-96.
22. Xiao Y, Lan L, Yin C, Deng X, Baker D, Zhou JM, Tang X. (2007). Two-component sensor RhpS promotes induction of Pseudomonas syringae type III secretion system by repressing negative regulator RhpR. Mol Plant Microbe Interact. 20(3):223-34.
23. n L, Deng X, Zhou JM, Tang X. (2006). Genome-wide gene expression analysis of Pseudomonas syringae pv. tomato DC3000 reveals overlapping and distinct pathways regulated by hrpL and hrpRS. Mol Plant Microbe Interact. 19(9):976-87.