基本信息 张伊
副教授
博士生导师
电子邮件：zhangyixjtu@xjtu.edu.cn

教育及工作经历 1. 2017.11~至今，西安交通大学医学部, 基础医学院, 生理学与病理生理学系，副教授
2. 2012.11~2017.10， 美国康奈尔大学威尔医学院病理与实验药物学系，博士后
（合作导师：Annarita Di Lorenzo 教授）
3. 2007.09~2012.07，北京大学分子医学研究所，生物物理学，理学博士学位
（导师：中国科学院院士 程和平教授）
4. 2003.09~2007.07，中国农业大学动物科学与技术学院，动物科学，学士学位

研究方向 1. 鞘磷脂代谢信号通路在心血管系统中的作用与机制
2. 心肌细胞钙稳态在心律失常中的作用与机制

主持的科研项目 1. 2019.01~2022.12，内皮细胞Nogo-B在高血压诱发冠状动脉粥样硬化过程中的作用与机制，国家自然科学基金面上项目，60.0万，主持
2. 2019.01-2020.12，冠状动脉内皮细胞中S1P-S1PR1在心脏重构中的作用与机制，陕西省自然科学基金青年项目，3.0万，主持
3. 2019.09-2024.09，西安交通大学医学部“攀登人才”支持计划，20.0万，主持
4. 2019.01-2021.12，2019T120919，Nogo-A调控线粒体钙转运及其对心肌肥大的影响研究，第12批中国博士后科学基金特别资助项目，18.0万，主持
5. 2019.01-2021.12，Nogo-B调控鞘磷脂代谢在高血压诱发冠状动脉粥样硬化中的作用，陕西省博士后基金项目，8.0万，主持
6. 2018.01-2020.12，2018M631174，S1PR1在压力超负荷所致心力衰竭中的作用与机制，第63批中国博士后科学基金面上项目一等资助，8.0万，主持
7. 2018.01-2020.12，S1PR1在RyR2磷酸化及心衰中的作用与机制研究，西安交通大学基本科研业务费，15.0万，主持
8. 2018.01-2020.12，冠状动脉内皮细胞S1PR1在压力超负荷所致心力衰竭中的作用与机制，西安交通大学新教师科研支持计划，15.0万，主持

已发表SCI论文 1. Ying Qi^#, Jing-Jing Li^#, Xiao-Hui Di^#, Yu Zhang^#, Jie-Long Chen, Zi-Xuan Wu, Zi-Yue Man, Ru-Yue Bai, Fujian Lu, Jie Tong, Xue-Liang Liu, Xiu-Ling Deng, Jianbao Zhang, Xing Zhang,Yi Zhang*, and Wenjun Xie*. Excess sarcoplasmic reticulum-mitochondria calcium transport induced by Sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy.Biochim Biophys Acta Mol Cell Res. 2021 Apr. 1868(5):118970. (IF:4.105)（第一通讯作者）
2.Yi Zhang^#, Ying Qi^#, Jing-Jing Li^#, Xiao-Hang Gao, Yu Zhang, Xia Sun, Wen-Jin He, Jie Tong, Jianbao Zhang, Xiu-Ling Deng, Xiao-Jun Du, Wenjun Xie*. Stretch-induced sarcoplasmic reticulum calcium leak promotes atrial fibrillation in pressure-overloaded hearts.Cardiovasc Res.2020 Jun 12:cvaa163. doi: 10.1093/cvr/cvaa163. Online ahead of print. (IF=8.168)
3.Yi Zhang^#, Meng-Chen Hou^#, Jing-Jing Li, Ying Qi, Yu Zhang, Gang She, Yu-Jie Ren, Wei Wu, Zheng-Da Pang, Wenjun Xie, Xiu-Ling Deng*, Xiao-Jun Du*. Cardiac β-adrenoceptor activation mediates diverse and cell type-dependent changes in the expression and distribution of connexin 43.J Cell Mol Med.2020 Aug; 24(15):8505-8517. (IF=4.658)
4. Gang She, Meng-Chen Hou, Yu Zhang,Yi Zhang, Yan Wang, Hui-Fang Wang, Bao-Chang Lai, Wei-Bo Zhao, Xiao-Jun Du, Xiu-Ling Deng*. Gal-3 (Galectin-3) and KCa3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by βAR (β-Adrenoceptor) Activation.Hypertension. 2020 Feb; 75(2):393-404. (IF=7.017)
5. Alice Marino,Yi Zhang, Luisa Rubinelli, Maria Antonietta Riemma, James E. Ip, Annarita Di Lorenzo*. Pressure overload leads to coronary plaque formation, progression and myocardial events in ApoE-/- mice.JCI Insight.2019 May 2; 4(9):e128220. (IF=6.014)
6. Gregory Farber, Matthew M. Parks, Nicole Lustgarten Guahmich,Yi Zhang, Sébastien Monette, Scott C. Blanchard, Annarita Di Lorenzo, Carl P. Blobe*,ADAM10 controls the differentiation of the coronary arterial endothelium,Angiogenesis. 2019 May; 22(2):237-250. (IF=5.759)
7. Ren Xu^#, Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin, Jung-Min Kim, Shawon Debnath, Gang Ji, Mathias P. Bostrom, Xu Yang, Chao Zhang, Han Dong, Pouneh Kermani, Sarfaraz Lalani, Na Li, Yifang Liu, Michael G. Poulos, Amanda Wach,Yi Zhang, Kazuki Inoue, Annarita Di Lorenzo, Baohong Zhao, Jason M. Butler, Jae-Hyuck Shim, Laurie H. Glimcher*, Matthew B. Greenblatt*, Targeting skeletal endothelium to ameliorate bone loss,Nat Med. 2018 Jun; 24(6):823-833.(IF=30.641)
8. Steven L Swendeman, Yuquan Xiong, Anna Cantalupo, Hui Yuan, Nathalie Burg, Yu Hisano, Andreane Cartier, Catherine H Liu, Eric Engelbrecht, Victoria Blaho,Yi Zhang, Keisuke Yanagida, Sylvain Galvani, Hideru Obinata, Jane E Salmon, Teresa Sanchez, Annarita Di Lorenzo, Timothy Hla*, An engineered S1P chaperone attenuates hypertension and ischemic injury,Sci Signal, 2017 Aug 15; 10(492):eaal2722. (IF=6.481)
9. Anna Cantalupo, Antonella Gargiulo, Elona Dautaj, Catherine Liu,Yi Zhang, Timothy Hla, and Annarita Di Lorenzo*, S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure.Hypertension. 2017 Jun 12; 70(2): 426~434. (IF=7.017)
10. Linda Sasset^#,Yi Zhang^#(co-first author), Teresa M. Dunn, and Annarita Di Lorenzo*. Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis.Trends Endocrinol Metab. 2016 Nov; 27(11):807-819. (IF=10.983)
11.Yi Zhang, Yan Huang, Anna Cantalupo, Paula S. Azevedo, Mauro Siragusa, Jacek Bielawski, Frank J. Giordano, and Annarita Di Lorenzo*. Endothelial Nogo-B regulates sphingolipid biosynthesis to promote the transition from hypertrophy to heart failure during chronic pressure overload.JCI Insight. 2016 Apr 21; 1(5): e85484. (IF=6.014)
12. Anna Cantalupo^#,Yi Zhang^#(co-first author), Milankumar Kothiya, Sylvain Galvani, Hideru Obinata, Mariarosaria Bucci, Frank J. Giordano, Xian-Cheng Jiang, Timothy Hla, and Annarita Di Lorenzo*. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.Nat Med. 2015 Sep; 21(9):1028-37. (IF=30.641)（共同第一作者）
13. Xianhua Wang*^#, Wenjun Xie^#,Yi Zhang^#(co-first author), Peihui Lin, Liang Han, Peidong Han, Yanru Wang, Zheng Chen, Guangju Ji, Ming Zheng, Noah Weisleder, Rui-Ping Xiao, Hiroshi Takeshima, Jianjie Ma*, and Heping Cheng. Cardioprotection of ischemia-reperfusion injury by cholesterol-dependent MG53-mediated membrane repair.Circ Res. 2010 Jul 9; 107(1):76-83. (IF=15.862) （共同第一作者）
14. Chun-Mei Cao, Yan Zhang, Noah Weisleder, Christopher Ferrante, Xianhua Wang, Fengxiang Lv,Yi Zhang, Ruisheng Song, Moonsun Hwang, Li Jin, Jiaojiao Guo, Wei Peng, Geng Li, Miyuki Nishi, Hiroshi Takeshima, Jianjie Ma, and Rui-Ping Xiao*. MG53 constitutes a primary determinant of cardiac ischemic preconditioning.Circulation. 2010 Jun 15; 121(23):2565-74. (IF= 23.054)

国际及国内会议及专题报告
1. 2019年9月19-22日，参加第十二届“海峡两岸心血管科学研讨会”，论文口头报告 “Stretch-induced sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in pressure-overloaded hearts” 获得大会“青年优秀论文”三等奖。
2. 2019 年 6月 3-6 日，参加第二十三届国际心脏大会（ISHR2019）,论文摘要“Cx43 expression in cardiac fibroblasts is upregulated by the activation of β2-AR/cAMP/PKA pathway” 获得 “青年科学家旅行奖”。并在“离子通道和心律不齐的新探索”的分会场中担任会议主席。
3. 2017年 5 月 1-5 日，参加9th International Ceramide Conference (Long Island, NY, USA), 论文摘要“Endothelial Nogo-B dependent Regulation of Sphingolipid Biosynthesis Promotes the Coronary Atherosclerosis Formation”, 并作口头报告。
4. 2016 年 7 月 18-20 日，参加 American Heart Association, Basic Cardiovascular Sciences Scientific Sessions 2016 (Phoenix, Arizona, USA), 论文摘要“Endothelial Nogo-B Regulates Sphingolipid Biosynthesis to Promote Pathological Cardiac Hypertrophy” 获得 “青年科学家旅行奖”。
5. 2016 年 5 月 13-17 日，参加 American Society of Hypertension Annual Scientific Meeting & Exposition 2016 (New York, NY, USA), 论文摘要 “Endothelial Nogo-B regulates sphingolipid biosynthesis to promote the transition from hypertrophy to heart failure during chronic pressure overload” 被选为会议最好的５个青年****摘要，并参加口头报告竞赛，获得第一名。