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西安交通大学医学部基础医学院导师教师师资介绍简介-张保军

本站小编 Free考研考试/2021-06-27



张保军
工作简历
2019年4月－至今：西安交通大学医学部基础医学院院长
中国西部科技创新港转化医学研究院院长；
2016年9月－至今：教授、博导，西安交通大学；
2015年9月－2016年9月：Research Scientist，免疫学，美国杜克大学；
2014年2月－2015年8月：Research Associate，免疫学，美国杜克大学；
2009年2月－2014年1月：博士后，免疫学，美国杜克大学。

招生方向：
1. 免疫细胞发育与功能的调控；
2. 免疫细胞在抗肿瘤、病毒感染中的作用；
3. 免疫细胞在自身免疫性疾病中的作用；
4. 幼年与老年免疫。

个人简介：
入选国家级人才计划，陕西省人才计划，陕西省“三秦****，”西安交通大学“青年拔尖人才（A类）”，目前担任中国免疫学会理事，陕西省抗癌协会副理事长，西安市免疫相关疾病基础与转化研究重点实验室主任，陕西高校青年创新团队带头人。在Immunity、Nature Immunology、PNAS、Plos Genetics、Journal of Immunology、Cell Reports等杂志上公开发表SCI论文31篇，共被引用1000余次；担任BMC Immunology、Frontiers Cell and Developmental Biology和Journal of Cellular and molecular medicine杂志副主编；International Immunopharmacology、Frontiers in Immunolog杂志编委。负责Journal of Autoimmunity、Journal of Leukocyte Biology、Cellular & Molecular Immunology和Apoptosis 等10多个杂志审稿工作。担任器官-系统整合“十三五”规划教材副主编。

研究方向：
实验室从分子、细胞及机体整体水平上，围绕调控T细胞发育及功能的分子机制方面展开科研工作，主要包括：（1）深入研究αβ 、γδ及NKT细胞在胸腺内的早期发育及在外周长期维持的分子机制，阐明各种T细胞亚群如何维持机体完整的免疫系统；（2）探讨调控效应性与记忆性T细胞 分化、维持的分子机制及其在抗感染、肿瘤等疾病中的应用；（3）研究调控效应性T细胞和调节性T细胞参与自身免疫性疾病发生的机制，寻找治疗自身免疫性疾病的靶点。

科研项目：
主持国际合作重点项目1项，国家自然基金面上项目1项，西安交通大学青年拔尖人才项目1项，西安交通大学菁英人才项目1项；参与多项国际、国家级科研项目。

联系方式：
电子邮箱：bj.zhang@mail.xjtu.edu.cn
联系电话：
联系地址：西咸新区中国西部科技创新港21号巨构
代表论文：
1. Baojun Zhang, Si-Qi Liu, Chaoran Li, Erik Lykken, Shan Jiang, Elizabeth Wong, Zhihua Gong, Zhongfen Tao, Bo Zhu, Ying Wan, Qi-Jing Li*. miR-23a curbs necrosis during early T cell activation by enforcing intracellular reactive oxygen species equilibrium. Immunity.2016, 44(3), 568-81.
2. Kun Zhu , Chenfeng He , Si-Qi Liu, Mingjuan Qu, Tao Xie, Xiaofeng Yang, Lei Lei, Xiaobo Zhou, Lin Shi, Dan Zhang, Yanbin Chen, Yae Sun, Huiqiang Zheng, Xiaonan Shen, Qijing Li, Ning Jiang, Baojun Zhang*. Lineage Tracking the Generation of T Regulatory Cells From Microbial Activated T Effector Cells in Naïve Mice[J]. Front Immunol, 2020, 10:3109.
3. Zhang B*, Jiao A, Dai M, Wiest DL, Zhuang Y. Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. J Immunol. 2018, 201(5):1452-1459.
4. Baojun Zhang, Qingzhu Jia, Cheryl Bock, Gang Chen, Haili Yu, Qingshan Ni, Ying Wan*, Qi-Jing Li*, and Yuan Zhuang*. A glimpse of natural selection of long-lived T cell clones in healthy life. Proc Natl Acad Sci U S A. 2016, 113(35): 9858-63.
5. Baojun Zhang*, Jianxuan Wu*, Yiqun Jiao?, Cheryl Bock?, Meifang Dai*, Benny Chen?, Nelson Chao*,?,?, Weiguo Zhang*,? & Yuan Zhuang*,?. Differential requirements of TCR signaling in homeostatic maintenance and function of Dendritic Epidermal T Cells. J Immunol. 2015, 195(9): 4282-91.
6. Zhang B, Dai M, Li QJ, Zhuang Y. Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination. PLoS Genet. 2013, 9(10): e**.
7. Xiaofeng Yang,Tongxin Dai, Xiaobo Zhou, Hongbo Qian, Rui Guo, Lei Lei, Dan Zhang, Lin Shi, Yanbin Cheng, Jinsong Hu, Yaling Guo, Baojun Zhang*. Naturally activated adaptive immunity in COVID-19 patients. J Cell Mol Med. 2020 (Accepted).
8. Lei Lei#1, Hongbo Qian#2, Xiaofang Yang1, Xingzhe Zhang1, Dan Zhang1, Tongxin Dai2, Rui Guo2, Lin Shi1, Yanbin Cheng1, Baojun Zhang1, Xiaobo Zhou1,4,5*, Jinsong Hu3*, Yaling Guo2*. The phenotypic changes of γδ T cells in COVID-19 patients. J Cell Mol Med. 2020 (Accepted).
9. Zhang B, Lin YY, Dai M, Zhuang Y. Id3 and Id2 Act as a Dual Safety Mechanism in Regulating the Development and Population Size of Innate-like γδ T Cells. J Immunol. 2014, 192(3):1055-63.
10. Zeng C#, Shi X#, Zhang B#, Liu H, Zhang L, Ding W, Zhao Y. The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med (Berl). 2012, 90(2): 175-86. (co-author)
11. Duan K#, Zhang B#, Zhang W, Zhao Y, Qu Y, Sun C, Zhao Y. Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells. Transpl Immunol. 2011, 25(4): 173-9. (co-author)
12. Zhang B, Zhang A, Qu Y, Liu J, Niu Z, Zhao Y*. Development of mouse CD4(+)CD25(+)Foxp3(+) regulatory T cells in xenogeneic pig thymic grafts. Transpl Immunol. 2009, 20(3):180-5.
13. Zhang B, Duan Z, Zhao Y*. Mouse models with human immunity and their application in biomedical research. J Cell Mol Med. 2009 Jun;13(6):1043-58.
14. Javeed A#, Zhang B#, Qu Y, Zhang A, Sun C, Zhang L, Liu J, Zeng C, Zhao Y. The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice. Transpl Immunol. 2009, 20(4): 253-60. (co-author)
15. Zhang B, Sun C, Qu Y, Zhang A, Liu J, Zhang L, Niu Z, Zhao Y*. Deficiency of mouse CD4+CD25+Foxp3+ regulatory T cells in xenogeneic pig thymus-grafted nude mice suffering from autoimmune diseases. Cell Mol Immunol. 2008, 5(5): 325-32.
16. Zhang B, Zhang A, Zhao Y*. Platelet aggregation and thrombosis in xenotransplantation between pigs and humans. Thromb Res. 2008,121(4): 433-41.
17. Baojun Zhang, Baosheng Ge, Xuepei Xia, Jun Liu, Liguang Sun, Enyu Rao and Yong Zhao*. Compatibility of Interleukin-2 between porcine and human: implication for xenotransplantation. Xenotransplantation. 2006, 13: 423-432.

18. Robins E, Zheng M, Ni Q, Liu SQ, Liang C, Zhang B, Guo J, Zhuang Y, He Y, Zhu P, Wan Y, Li QJ*. Conversion of effector CD4+ T cells to a CD8+ MHC II-recognizing lineage. Cell Mol Immunol. 2020;10.1038/s41423-019-0347-5.

19. Sandrock I, Reinhardt A, Ravens S, Binz C, Wilharm A, Martins J, Oberdörfer L, Tan L, Lienenklaus S, Zhang B, Naumann R, Zhuang Y, Krueger A, Förster R, Prinz I. Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. J Exp Med. 2018 Dec 3;215(12):3006-3018.
20. Carico ZM, Roy Choudhury K, Zhang B, Zhuang Y and Krangel MS. TCRd rearrangement redirects a processive Tcra Recombination program to expand the Tcra repertoire. Cell Rep. 2017,19(10): 2157-2173.
21. Li J, Roy S, Kim YM, Li S, Zhang B, Love C, Reddy A, Rajagopalan D, Dave S, Diehl AM and Zhuang Y. Id2 collaborates with Id3 to suppress invariant NKT and innate-like tumors. J Immunol. 2017,198(8): 3136-3148.
22. Liu SQ, Jiang S, Li C, Zhang B, Li QJ. miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. J Biol Chem. 2014, 289(18):12446-56
23. Zeng C, Shi X, Zhang B, et al. The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med (Berl). 2012;90(2):175-186.
24. Maruyama T, Li J, Vaque JP, Konkel JE, Wang W, Zhang B, Zhang P, Zamarron BF, Yu D, Wu Y, Zhuang Y, Gutkind JS, Chen W. Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol. 2011, 12(1): 14-16.
20.Qu Y, Jin S, Zhang A, Zhang B, Shi X, Wang J, Zhao Y. Gamma-ray resistance of regulatory CD4+CD25+Foxp3+ T cells in mice. Radiat Res. 2010,173(2):148-57.
25. Qu Y, Zhang B, Liu S, Zhang A, Wu T, Zhao Y. 2-Gy whole-body irradiation significantly alters the balance of CD4(+)CD25(-)T effector cells and CD4(+)CD25(+)Foxp3(+)T regulatory cells in mice. Cell Mol Immunol. 2010, 173(2): 148-157.
26. Javeed A, Hou Y, Duan K, Zhang B, Shen H, Cao Y, Zhao Y. Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice. Inflamm Res. 2011, 60(4): 389-398.
27. Zheng Q, Xu Y, Liu Y, Zhang B, Li X, Guo F, Zhao Y. Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice. J Mol Med. 2009 Dec;87(12):1191-205.
28. Zhang B, Zhang A, Zhao Y. Platelet aggregation and thrombosis in xenotransplantation between pigs and humans. Thromb Res. 2008;121(4):433-441.
29.Aijun Zhang, Yanyan Qu, Baojun Zhang, Lianjun Zhang, Chun Zeng, Xuebing Ji, Ming Hou, Yong Zhao. Effect of indirubin on CD4+CD25+ Treg in mice. J Mol Med. 2007 Nov;85(11):1263-70.
30.Qu Y, Zhang B, Zhao L, Liu G, Ma H, Rao E, Zeng C, Zhao Y. The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice. Transpl Immunol. 2007 Apr;17(3):153-61.
31. Wang H, Zhao L, Sun Z, Sun L, Zhang B, Zhao Y. A potential side effect of cyclosporin A: inhibition of CD4(+)CD25(+) regulatory T cells in mice. Transplantation. 2006 Dec 15;82(11):1484-92.




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