西安交通大学化学学院导师教师师资介绍简介-张祯

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个人简介 - 张祯Welcome

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西安交通大学科研院

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个人简介
博士，硕士研究生导师，先后主持国家自然科学基金、陕西省科技攻关、中央高校基本科研基金；发表SCI学术论文20余篇，申请国家发明专利7项，已授权4项；Sensors & Actuators B Chemical,Journal of Materials Chemistry B,Talanta,Analyst,Industrial & engineering chemistry research,Inorganic Chemistry Communications,Analytical Methods,Photochemical & Photobiological Sciences等多个知名国际学术期刊审稿人。

研究兴趣与方向
主要从事荧光分子材料及其应用研究，研究内容涉及：
1. 基于化学反应和分子识别的有机分子光学探针与生
物成像
2. 基于主客体化学、超分子化学、光化学和生物技术
的刺激响应型发光功能材料
3.响应性发光智能材料用于检测、可逆显示、防伪油
墨和信息加密

背景经历
2010.08– 西安交通大学理学院
2008.07–2010.08 厦门大学化学化工学院化学生物学系
2003.09–2008.07 清华大学化学系生命有机磷化学及化学生
物学教育部重点实验，硕博连读
1999.09–2003.07 郑州大学化学系“国家理科基础科学研究
和教学人才培养基地”，学士

科学前沿
Angew. Chem.：室温下自发快速的固态分子运动
2019-03-12

通过晶体多构型调控单分子荧光-磷光双发射
2019-03-12

核壳型环糊精金属有机框架实现晶态白光发射
2019-03-12

Angew. Chem.：温度/压力双刺激响应的动态配位网络实现完全可逆的宽范围荧光调控
2019-03-10

更多新闻>>

发表论文 - 张祯发表论文
Huanhuan Song, Zhen Zhang*.A quinoline-based ratiometric fluorescent probe for discriminative detection of Zn²⁺ and Cd²⁺ with different binding modes, and its Zn²⁺ complex for relay sensing of pyrophosphate and adenosine triphosphate. Dyes and Pigments, 2019, 165, 172.
A new and simple quinoline-based fluorescent probe for discriminative sensing of Zn²⁺ and Cd²⁺ has been synthesized by inserting an amide group into the 8-aminoquinoline fluorophore and a propargylamine chelating site. This easily-available chemosensor displayed selective and distinct ratiometric fluorescence responses to Zn²⁺ in almost totally water solution through its amide tautomer binding form, and to Cd²⁺ in CH₃CN aqueous medium through its imidic acid tautomer binding form, respectively. Moreover, the in situ prepared probe 1–Zn²⁺ complex could act as a relay fluorescent sensor selectively toward pyrophosphate (PPi) and adenosine 5’-triphosphate (ATP) anions via further complexation. Thus, with good specificity, low detection limits and fast response time, a highly efficient fluorescence platform for simultaneous multi-analyte detection has been developed by using the uncomplicated single molecule. Finally, this multi-functional probe was applied successfully for analysis of all the target ions in the tap water sample and on test paper strips, and bioimaging of Zn²⁺ in mung bean sprouts with low phytotoxicity.
Zhen Zhang*, Chengquan Deng, Huanhuan Song.A novel rhodamine-based turn-on fluorescent probe for dual detection of Cr³⁺ and Cu²⁺ with solvent-dependent binding properties. Inorganic Chemistry Communications, 2018, 95, 56.
A new and simple 8-aminoquinoline–rhodamine conjugate-based fluorescent probe was constructed. This chemosensor displayed simultaneously significant fluorescent enhancement for Cr³⁺ in CH₃CN solution and Cu²⁺ in ethanol solution with high selectivity and sensitivity. The solvent-dependent binding modes provided facile and efficient dual-analyte fluorescent detection. Besides, the concomitant differentiable colorimetric changes with Cr³⁺ and Cu²⁺ in CH₃CN medium contributed easy and sensitive analysis of both cations by absorbance measurements and naked eyes. Finally, the probe was applied to detect Cr³⁺ and Cu²⁺ on silica gel plates.
Zhen Zhang*, Chengquan Deng, Yuan Zou, Lei Chen. A novel fluorescent and colorimetric probe for cascade selective detection of Fe(III) and pyrophosphate based on a click generated cyclic steroid-rhodamine conjugate.Journal of Photochemistry and Photobiology A: Chemistry, 2018, 356, 7.
A novel fluorescent and colorimetric probe containing deoxycholic acid and rhodamine moieties was developed by click chemistry, and its cascade selective detection of ferric ion (Fe³⁺) and pyrophosphate (PPi) was investigated in details by spectral measurements. The probe displayed turn-on orange fluorescence and colorless to pink color change upon binding with Fe³⁺ by reversibly forming the metal complex and opening the spirolactam ring of rhodamine. Through a tandem ligand exchange, PPi with higher affinity for Fe³⁺ removed the metal from the complex and restored the spectral signal of the probe. The experimental results suggested that this novel molecule could serve as an efficient and economical dual signal chemosensing system for cascade bi-target analysis of Fe³⁺ and PPi with high selectivity, low detection limits and fast response time. Notably, this bi-functional probe also showed excellent performances in monitoring Fe³⁺ and PPi on silica gel plates, in water samples and living cells.
Zhen Zhang*, Yuan Zou, Chengquan Deng. A novel and simple solvent-dependent fluorescent probe based on a click generated 8-aminoquinoline–steroid conjugate for multi-detection of Cu(II), oxalate and pyrophosphate. RSC Advances, 2017, 7, 14742.
In this work, a novel and simple deoxycholic acid-based fluorescent probe for solvent-dependent multi-detection of Cu²⁺, C₂O₄^2– and P₂O₇^4– has been facilely constructed by click chemistry. This probe displayed sensitive recognition toward Cu²⁺ in low-water-content CH₃CN aqueous solution (CH₃CN–H₂O, 99/1, v/v) via strong fluorescence quenching. Whereas, in DMSO–H₂O medium (1/1, v/v), it exhibited significant fluorescent enhancement for C₂O₄^2– and P₂O₇^4– over a wide range of tested anions. Moreover, with low detection limits and fast response time, the developed fluorescent molecule was used successfully for analysis of the target ions on test paper strips and in water samples.

Zhen Zhang*, Yuan Zou, Chengquan Deng, Liesu Meng. A simple rhodamine hydrazide-based turn-on fluorescent probe for HOCl detection. Luminescence, 2016, 31, 997.
Hypochlorous acid (HOCl) plays a crucial role in daily life and mediates a variety of physiological processes, but abnormal levels of HOCl has been associated with numerous human diseases. It is therefore of significant interest to establish a simple, selective, rapid, and sensitive fluorogenic detection of HOCl in environmental and biological samples. A hydrazide-containing fluorescent probe based on a rhodamine scaffold was facilely developed that could selectively detect HOCl over other biologically relevant reactive oxygen species (ROS), reactive nitrogen species (RNS), and most of the common metal ions in vitro. By an irreversible oxidation–hydrolysis mechanism, upon HOCl-triggered opening of the intramolecular spirocyclic ring during the detection, the rhodamine hydrazide-based probe exhibited large fluorescence enhancement in the emission spectra with fast response, low detection limit, and comparatively wide pH detection range in aqueous media. The probe was further successfully applied to monitoring trace HOCl in real tap water and imaging both exogenous and endogenous HOCl within living cells. It is anticipated that the simple and useful probe might be an efficient tool to facilitate more HOCl-related chemical and biological researches.

Zhen Zhang*, Chengquan Deng, Liesu Meng, Yan Zheng, Xiaomei Yan. A rhodamine hydrazide-based fluorescent probe for sensitive and selective detection of hypochlorous acid and its application in living cells. Analytical Methods, 2015, 7, 107.
A simple rhodamine hydrazide-based fluorescent turn-on probe was developed for fluorescence detection of hypochlorous acid (HOCl) in aqueous media and living cells. On the basis of a HOCl-mediated oxidation-hydrolysis mechanism, this new probe features high sensitivity, comparatively wide pH detection range, fast-response, and great photostability toward HOCl in aqueous solution. Owing to its hydrazide structure, the probe also exhibits excellent selectivity for HOCl over a panel of biologically relevant reactive oxygen species (ROS), reactive nitrogen species (RNS), and most of the common metal ions in neutral buffer. Particularly, with cell membrane permeability and low cytotoxicity, the probe is capable of responding to intracellular changes in HOCl levels in living cells by fluorescence imaging and flow cytometry.

张祯*,邓成权, 郭添, 孟列素.一种罗丹明类次氯酸荧光探针的合成与分析应用.分析测试学报, 2014, 33, 7.
以罗丹明为荧光团，肼为识别基团，通过一步反应合成了一种次氯酸(HOCl)荧光探针罗丹明6G酰肼，用核磁和质谱对探针结构进行了表征，并研究了其检测HOCl的荧光性能。实验结果表明，探针对HOCl的荧光分析具有较高的灵敏性和选择性。利用不可逆的氧化还原反应，探针在中性溶液中快速产生与HOCl浓度呈线性比例的荧光增强信号，检测的线性范围为2~400 μmol/L，检出限为0.06 μmol/L，其他常见活性氧物种对检测影响小。探针能够可视化分析HOCl，并在Hela活细胞中实现了HOCl的荧光成像。

Zhen Zhang*, Yan Zheng, Wei Hang, Xiaomei Yan, Yufen Zhao. Sensitive and selective off–on rhodamine hydrazide fluorescent chemosensor for hypochlorous acid detection and bioimaging. Talanta, 2011, 85, 779.

A rhodamine 6G hydrazide fluorescent chemosensor was prepared for the rapid HOCl detection in aqueous media. The system makes good use of the irreversible HOCl-mediated selective oxidation reaction to generate fluorescent response proportional to the amount of HOCl in neutral buffer. This probe exhibits great photostability, high sensitivity, and good selectivity for HOCl over other reactive species and most of the common metal ions. Furthermore, the probe is cell membrane permeable, and its applicability has been successfully demonstrated for fluorescence imaging of both exogenous and endogenous HOCl within living cells. Cytotoxicity assays prove that this probe is almost nontoxic to the cultured cell lines under the experimental conditions.
金励铭, 张祯*, 赵晓佳. 一种结构新颖的对肼和pH双响应的荧光探针的合成和性质. 第十届全国化学生物学学术会议, 2017, 武汉, 国内会议.
邹媛, 邓成权, 赵晓佳, 张祯*. 一种新颖的溶剂依赖型荧光探针的合成及性质研究. 中国化学会第30届学术年会, 2016, 大连, 国内会议.
Zhen Zhang*, Tian Guo, Liesu Meng. A Rhodamine Hydrazide Fluorescent Probe for Selective Detection of Hypochlorous Acid in Living Cells. 第八届全国化学生物学学术会议, 2013, 上海, 国内会议.
张祯, 杭纬, 赵玉芬, 颜晓梅. 罗丹明类次氯酸荧光探针的设计合成及其识别性能的研究. 中国化学会第27届学术年会, 2010, 厦门, 国内会议(优秀论文奖).
Xiang Gao, Feng Ni, Jin Bao, Yan Liu, Zhen Zhang, Pengxiang Xu, Yufen Zhao. Formation of cyclic acylphosphoramidates in mass spectra of N-monoalkyloxyphosphoryl amino acids using electrospray ionization tandem mass spectrometry. Journal of Mass Spectrometry, 2010, 45, 779.

Zhen Zhang, Yuan Ma, Yufen Zhao. Microwave-assisted one-pot synthesis of dihydrocoumarins from phenols and α,β-unsaturated acyl chloride. Synlett, 2008, (7), 1091.
张祯, 麻远, 赵玉芬. 微波辅助的Friedel-Crafts反应研究进展. 化学进展, 2008, 20, 312.
Zhen Zhang, Yong Ju, Yufen Zhao. Synthesis of 1,2,3-triazole-containing bile acid dimers and properties of inverse micellar mimic. Chemistry Letters, 2007, 36, 1450.
Zhen Zhang, Mingyu Niu, Yong Ju, Yufen Zhao. Studies on the DNA binding and cleavage activity of a synthesized polyamide containing dipeptide Ser-His. Science in China Series B–Chemistry, 2007, 50, 806.
张祯, 巨勇, 赵玉芬. 利用1,3-偶极环加成反应合成胆甾二聚体. 有机化学, 2007, 27, 64.
Yan Li, Zhen Zhang, Yong Ju, Changqi Zhao. Design, synthesis and antitumor activity of dimeric bile acid-amino acid conjugates. Letters in Organic Chemistry, 2007, 4, 414.
Qiang Yin, Zhen Zhang, Yufen Zhao. Studies of interaction between a new synthesized minor-groove targeting artificial nuclease and DNA. Spectrochimica Acta Part A–Molecular and Biomolecular Spectroscopy, 2007, 66, 904.
Qiang Yin, Zhen Zhang, Yufen Zhao. Studies on a novel minor-groove targeting artificial nuclease: Synthesis and DNA binding behavior. Chemical Research in Chinese Universities, 2007, 23, 44.
Qiang Yin, Zhen Zhang, Yufen Zhao. DNA binding and cleavage property of pyrenyl-mac rocyclic polyamine conjugate. Chinese Chemical Letters, 2006, 17, 1185.
Qiang Yin, Zhen Zhang, Yufen Zhao. A highly-selective probe for detection of zinc(II) in neutral aqueous solution. Journal of Chemical Research–S, 2006, (3), 160.
Renzhong Qiao, Zhen Zhang, Yong Ju, Chuanqin Xia, Xiaoqi Yu, Yufen Zhao. Electrospray ionization mass spectral characteristics of polyamide containing 1,4,7,10-tetraazacyclododecane. Chinese Journal of Chemistry, 2006, 24, 923.

发明专利 - 张祯发明专利
张祯, 唐甲旭. 一种用于电子墨水显示的红色荧光微胶囊及其制备方法. 发明专利, 申请号：2.5.
张祯, 唐甲旭. 一种用于电子墨水显示的蓝色电泳粒子及其制备方法. 发明专利, 申请号：2.9.
张祯, 宋欢欢. 8-氨基喹啉酰胺衍生物、制备方法、应用及其荧光分析的方法. 发明专利, 申请号：3.2.
张祯, 邓成权, 邹媛. 含8-氨基喹啉基团的罗丹明B衍生物、制备方法、应用及对Cr³⁺及Cu²⁺进行荧光分析的方法. 发明专利, 专利号：ZL 2015 1 **.6.

张祯, 邓成权, 刘小龙. 一种用于次氯酸检测的荧光磁性纳米粒子及其合成方法. 发明专利, 专利号：ZL 2014 1 **.5.
张祯, 邓成权, 孟列素, 颜晓梅. 罗丹明6G酰肼衍生物、其制备方法、应用及作为荧光探针对次氯酸进行荧光分析的方法. 发明专利, 专利号：ZL 2014 1 **.5.
赵玉芬, 乔仁忠, 张祯. 一种大环多胺与聚酰胺缀合物及其制备方法与应用. 发明专利, 专利号：CN6.3.

科研项目 - 张祯科研项目

没有找到条目。

项目编号项目名称项目来源起讫时间承担角色项目类别
含胆甾骨架的聚集荧光增强型超分子体系的可控构筑与可视化成像中央高校基本科研业务费专项资金 2016-3~ 负责人纵向项目
2015GY148 高强度、快响应的多色微胶囊型电子墨水显示材料与性能研究陕西省工业科技攻关项目 2015-1~ 负责人纵向项目
xjj** 生物体内次氯酸检测的比率型荧光探针的设计合成和应用中央高校基本科研业务费专项资金 2012-1~ 负责人纵向项目
** 用于生物体和环境水中次氯酸检测的荧光多孔磁性硅球的制备和应用国家自然科学基金项目 2012-1~ 负责人纵向项目
基于细胞内功能性活性物种检测的新型荧光探针的设计合成及其识别性能的研究西安交通大学新教师科研支持计划 2011-1~ 负责人纵向项目

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研究小组 - 张祯研究生培养
唐甲旭, 2018级研究生
宋欢欢, 2017级研究生
金励铭, 2016级研究生
赵晓佳, 2015级研究生
邹媛, 2014级研究生, 已毕业, 中国科学院地球环境研究所工作
邓成权, 2013级研究生, 已毕业, 河南省公安厅反恐情报信息总队工作

本科生培养
王毅博, 2019年本科毕业设计；杨乐乐, 2018年本科毕业设计；
杨羽佳, 2017年本科毕业设计；涂北凯, 2016年本科毕业设计；
高国伟, 2016年本科毕业设计；刘勃, 2015年本科毕业设计；
王定文, 2014年本科毕业设计；袁娇, 2013年本科毕业设计；
刘小龙, 2013年本科毕业设计；郭添, 2011年本科毕业设计
辜黎, 2018年本科科研训练；杨松磊, 2018年本科科研训练；
陈雷, 2016年本科科研训练；寇华日, 2013年本科科研训练；
万文瞾, 2013年本科科研训练；刘小龙, 2012年本科科研训练

课堂教学 - 张祯讲授课程
《大学化学 I》，主讲，本科生课程
《大学化学 I 实验》，主讲，本科生课程
《基础化学实验原理》，主讲，本科生课程
《有机实验 I》，主讲，本科生课程
《有机化学》（理科），教辅，本科生课程
《有机化学实验》，主讲，本科生课程
《化学专业讲座》，本科生课程
《有机化学 MOOC》，参与，本科生课程，中国大学MOOC平台发布

教改项目
《移动互联环境下科学类通识选修课程面临的机遇、挑战和对策研究》, 陕西省高等教育学会高等教育科学研究项目, 省级教改项目, 本科生教学, 2108年3月立项, 参与
《应用电化学》, 校级“十三五”规划教材第二批建设项目, 院校级教改项目, 本科生教学, 2108年3月立项, 参与
《加快大学化学实验教学, 培养学生基本科研素养》, 院校级教改项目, 本科生教学, 2016年9月立项, 参与

参编书籍
《大学化学实验》, 科学出版社, ISBN 978-7-03-058629-2, 2018年9月, 参编
《化学综合实验》, 西安交通大学出版社, ISBN 978-7-5605-5788-5, 2014年2月, 参编

荣誉称号
2011.09–2015.07担任本科应用化学11班班主任
2014年指导应用化学11班荣获本科“优秀专业实习队”称号

招生信息 - 张祯招生信息
欢迎有志于从事科学研究，具有化学、材料或化学生物学等背景知识的优秀学子报考！

研究生报考信息查询：
西安交通大学研究生招生信息网http://yz.xjtu.edu.cn/