丁健


研究领域（方向）
1. 调控肌肉舒缩的遗传学网络
2. 线粒体与肌肉生理病理
3. 线粒体信号传导
个人及工作简历
07/2001, 学士, 生物学, 南京大学
07/2003, 硕士, 生物学, 南京大学
05/2010, 博士, 生物化学, 美国爱荷华州立大学
07/2010-03/2014, 博士后, 美国哈佛医学院/波士顿儿童医院
03/2014-06/2017, 讲师, 美国哈佛医学院/波士顿儿童医院
07/2017- 至今, 教授, 西安交通大学
科研项目
1. 调控肌肉舒缩的遗传学网络 (西安交大青拔A类人才基金)
2. Trbp的互作因子Prmt5对心肌中快慢肌纤维基因表达的调控效应和作用机制 (自然科学基金面上项目)
学术及科研成果、专利、论文
论文及代表作:
Diniz G, Huang Z-P, Liu J, Chen J,Ding J, Fonseca R, Barreto-Chaves ML, Donato J, Hu X, Wang D-Z (2017) Loss of microRNA-22 prevents high fat diet induced dyslipidemia and increase energy expenditure without affecting cardiac hypertrophy.Clin Sci.In press
Ding J*, Lin Z-Q, Jiang J-M, Seidman CE, Seidman JG, Pu WT and Wang D-Z* (2016) Preparation of rAAV9 to overexpress or knockdown genes in mouse heart. J Vis Exp. 118:e54787, doi:10.3791/54787 (*Co-corresponding author)
Ding J, Nie M, Liu J, Hu X, Ma L, Deng Z-L and Wang D-Z (2016) Trbp is required for differentiation and normal regeneration of skeletal muscle. PLoS ONE. 11:e**. doi: 10.1371/journal.pone.**
Ding J, and Wang D-Z (2015) Mystery of Trbp, tale of a RBP in the miRNA pathway. Cell Cycle. 14:3007-3008
Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng Z-L, Pu WT and Wang D-Z (2015) Trbp regulates heart function through miRNA-mediated Sox6 repression. Nat Genet. 47: 776-783
Huang Z-P, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng Z-L, Seidman CE, Seidman JG, Pu WT and Wang D-Z (2015) Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 125: 4122-4134
Ambrosio L, Morriss S, Riaz A, Bailey R, Ding J and MacIntosh GC (2014) Phylogenetic analyses and characterization of RNase X25 fromDrosophila melanogastersuggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. PLoS ONE. 9:e105444. doi:10.1371/journal.pone.**
Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang D-Z, Li K, Wang J, Wangders RA, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK and Pu WT (2014) Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 20:616-623
Seok H, Chen J, Kataok M, Huang Z-P, Ding J, Yan J, Hu X and Wang D-Z (2014) Loss of microRNA-155 protects the heart from pathological cardiac hypertrophy. Circ Res. 114:717-729
Chen J, Huang Z-P, Seok H, Ding J, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R and Wang D-Z (2013) miR-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 112:1557-1568
Ding J, and Wang D-Z (2011) “RISCing” the heart: In vivo identification of cardiac miRNA targets by RISCome. Circ Res. 108:3-5
Mckay J, Wang X, Ding J, Buss JE and Ambrosio L (2011) H-RAS resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes. Biochim Biophys Acta. 1813:298-307
Ding J, Tchaicheeyan O and Ambrosio L (2010) Drosophila Raf’s N-terminus contains a novel conserved region and can contribute to Torso RTK signaling. Genetics. 184:717-729
Ding J, Shi S, Jiang B-H, Yang Y-H, Huang J, Shen H-G, Xia K, Zhang J and Jiang X (2004) Effects of methyl jasmonate with IAA and 6-BAP on the secondary metabolism of cultured Onosma paniculatum cells. In Vitro Cell Dev Pl. 40:581–585
Yang Y-H, Huang J and Ding J (2003) Interaction between exogenous Brassinolide, IAA and BAP in secondary metabolism of cultured Onosma paniculatum cells. Plant Growth Regul. 39: 253–261
Book Chapters:
Ding J, and Wang D-Z (2013) “Role of microRNAs in cardiac hypertrophy and post-infarction remodeling” Cardiac Remodeling. “Advances in Biochemistry in Health and Disease” 5: 293-311. Springer, New York.
联系方式
电子邮箱：jianding@xjtu.edu.cn

联系电话：
个人主页： http://gr.xjtu.edu.cn/web/jianding
联系地址：陕西省西安市碑林区咸宁西路28号西安交通大学生命科学与技术学院

更新日期：2018-01-08