田中民


研究领域（方向）
主要研究兴趣包括：盐敏感高血压的差异蛋白质组学与代谢组学；肾性高血压代谢的建模与计算；盐敏感高血压的药物靶标筛选以及诊断试剂盒开发；生物质谱分析技术。近年主要围绕盐敏感高血压大鼠肾脏代谢特征展开相关蛋白质组学、代谢组学研究，详细探讨了盐敏感高血压疾病进展过程中，肾脏代谢的规律性。部分研究结果发表在《cell reports》《Hypertension》《Genome research》《Nucleic Acids Research》《Am J Physiol Renal Physiol》等学术期刊上。
个人及工作简历
田中民教授，博士生导师。1991年毕业于西北大学生物系；2000年，西北大学生物系获硕士学位；2004年西安交通大学生物医学工程系获博士学位；2006－2008美国威斯康星医学院，生理系博士后研究工作；2008年入选教育部“新世纪优秀人才”支持计划；2009年美国威斯康星医学院生理系访问****。2010年西安交通大学生命科学与技术学院教授。
科研项目
[1] 国家自然科学基金面上项目，**、肾脏氨基酸代谢异常与盐敏感高血压形成机制的研究、2018/01-2021/12、52万元、在研、主持。
[2] 国家自然科学基金面上项目，**、肾脏代谢反馈调节与盐敏感高血压的形成机制研究、2016/01-2019/12、57万元、在研、主持。
[3] 国家自然科学基金面上项目，**、延胡索酸酶基因(Fh)突变在高盐饮食肾损伤及血压盐敏感性形成中的作用、2013/01-2016/12、70万元、在研、主持。
[4] 国家自然科学基金海外及港澳****合作研究基金项目，**、肾脏细胞代谢中产物对盐敏感性高血压的调控机制研究、2013/01-2014/12、20万、已结题、合作人。
[5] 国家自然科学基金面上项目，**、糖、脂代谢紊乱与盐敏感高血压形成分子机理的研究、2011/01-2013/12、36万元、已结题、主持。
[6] 科技部国家重点基础研究973计划项目，2010CB732600、心脑血管易损斑块的高分辨成像识别与风险评估预警体系重大问题的基础研究、2009/01-2014/7、500万、已结题、参与。
[7] 教育部新世纪优秀人才支持计划项目，NCET-080434、医学超声生物损伤的分子机理研究、2009/01-2011/12、50万、已结题、主持。
[8] 人事部留学人员科技活动择优资助项目，SLZ**、盐敏感高血压临床检测试剂盒研制、2009/01-2011/12、17万、已结题、主持。
学术及科研成果、专利、论文
[1] Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang*, Zhongmin Tian,* Malate and Aspartate Increase L-arginine and Nitric Oxide and Attenuate Salt-Sensitive Hypertension. Cell Reports. 2017 19, 1631–1639 IF: 8.28
[2] Yang Z, Sun N, Cheng R, Zhao C, Liu Z, Li X, Liu J, Tian Z. pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. Biomaterials. 2017 Sep10;147:53-67. doi: 10.1016/j.biomaterials.. SCI 一区IF:8.402
[3] Yang Z., Sun N., Cheng R., Zhao C. Y., Liu J. and Tian Z. Hybrid nanoparticles coated with hyaluronic acid lipoid for targeted co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells (2017). Journal of Materials Chemistry B, 5: 6762-6775. IF:4.543 SCI 一区
[4] Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z*, Liang M*. Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain. Physiol Genomics. 2017 Sep 1;49(9):496-504. IF:3.04
[5] Liqing He, Xiaochang Xue, Zhengjun Wang, Entai Hou, Yong Liu, Mingyu Liang, Yingqi Zhang, and Zhongmin Tian* Transcriptional regulation of heterogeneous nuclear ribonuc leoprotein K gene expression, Biochimie, 2015, 109, 27-35 IF: 3.2
[6] Le Wang , Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian* Reconstruction and analysis of correlation networks based on GC–MS metabolomics data for young hypertensive men, Analytica Chimica Acta , 2015,854: 95–105 IF：4.517
[7] Le Wang, Entai Hou, Liqing He, Zhengjun Wang, Na Sun, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian* Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats.Biochemical and Biophysical Research Communications, 2014, 18, 450 (1): 863-869. IF: 2.4
[8] Zhongmin Tian*, Yu Wang, Chenyang Zhao, Tianshu Wang, Entai Hou and Na Sun Qualitative and quantitative analysis of phosphoproteomic experimental workflow based on phosphoprotein enrichment strategy and two-dimensional difference gel electrophoresis (2D-DIGE) techniques, Current Proteomics, 2014, 11(4), 252 – 263 IF: 0.5
[9] Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang*. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009, 54: 255-260. IF: 7.194
[10] Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411. IF: 11.224
[11] Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008,51(4):899-904. IF: 7.194
[12] Zhongmin Tian, Mingxi Wan, Mingzhu Lu, Xiaodong Wang. The alteration of protein profile of walker 256 carinosarcoma cells during the apoptotic process induced by ultrasound. Ultrasound in Medicine & Biology, 2005, 31 (1): 121-128. IF: 2.221
[13] Zhongmin Tian, Mingxi Wan, Supin Wang, Juqing Kang. Effects of ultrasound and excipients on the function and structure of trypsin. Ultrasonics Sonochemistry 2004, 11(6), 399-404. IF: 2.105
[14] Zhongmin Tian, Mingxi Wan, Bo Wang, Supin Wang, Xiaoming Wu and Yusong Ruan. Effects of ultrasound on the structure and function of tumor necrosis factor-α. Ultrasound in Medicine & Biology, 2003, 29 (9): 1331-1339. IF: 2.221
[15] Zhongmin Tian, Mingxi Wan, Zenglu Wang, Bo Wang. The preparation of genistein and LC-MS/MS on line analysis. Drug Development Research, 2004, 66 (1): 6-12. IF: 0.891
[16] Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian，Domagoj Mladinov，Isaac R. Matus, Xiaoqiang Ding, Andrew S. Greene and Mingyu Liang. MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF：7.479
[17] Xiaofeng He , Yong Liu , Kristie Usa , Zhongmin Tian, Allen W. Cowley Jr., Mingyu Liang. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2014, 15; 306(10):1190-1197. IF：3.3
[18] Mingyu Liang, Yong Liu, Domagoj Mladinov, Allen W. Cowley, Jr., Hariprasad Trivedi, Yi Fang, Xialian Xu, Xiaoqiang Ding, Zhongmin Tian. MicroRNA: A New Frontier in Kidney and Blood Pressure Research. Am J Physiol Renal Physiol, 2009，297:553-558. IF：4.416
[19] Yi Feng, Zhongmin Tian, Ming-Xi Wan. Bio-effects of low intensity ultrasound in vitro: apoptosis, alteration of protein profile and potential molecular mechanism. Journal of Ultrasound in Medicine. 2010, 29: 963-974 SCI：607CB
[20] Yi Feng, Zhongmin Tian, Ming-Xi Wan, Zhao-Bin Zheng. Protein profile of human hepatocarcinoma cell line SMMC-7721: Identification and functional analysis. World J Gastroenterol, 2007, 13(18): 2608-2614 SCI :175PE
联系方式
电子邮箱：zmtian@xjtu.edu.cn

联系电话：-92
个人主页： http://gr.xjtu.edu.cn/web/zmtian
联系地址：西安交通大学教二北楼

更新日期：2020-05-28