宗瑜瑾


研究领域（方向）
1.超声造影成像、超分辨成像；
2.超声基因/药物递送
3.多模超声造影剂及其诊疗应用
个人及工作简历
西安交通大学生命科学与技术学院教授，博士生导师。2006年西安交通大学生物医学工程专业博士毕业后留校工作，2015年2月-2016年1月在美国华盛顿大学工业与医学超声中心作访问****。现任西安交通大学生物医学影像与应用研究所副所长。
主讲研究生课程“波动理论及其医学应用”。近年来主持国家级科研项目6项，包括国家重点研发计划项目课题1项、国家自然科学基金面上项目5项；作为骨干人员参与国家重大科学仪器研制项目1项、973项目课题1项，发表SCI论文40余篇，授权发明专利4项，作为副主编出版教材2部，撰写出版英文专著1章，作为主要完成人获陕西省科技进步一等奖1项，参与完成的研究成果入选“2017年中国医学十大进展”。现任陕西省超声医学工程学会常委，中国超声医学工程学会仪器工程开发专委会、中国生物医学工程学会医学超声工程分会、中国超声医学工程学会超声治疗及生物效应专委会、中国超声医学工程学会分子影像专委会委员。
科研项目
1. 国家自然科学基金面上项目（**），肿瘤微血管内外微泡和相变液滴定位复合超分辨超声成像及其引导的液滴介导药物递送，2021.01-2024.12，61万元，在研，主持
2. 国家重大科研仪器研制项目 (**)， 超声脑小血管超分辨及动态多参量成像系统，2019.01-2023.12，796.72万元，在研，主要参加
3. 国家自然科学基金面上项目（**），超声/磁场对双峰分布相变纳米液滴的协同操控及其在肿瘤诊疗中的应用，2018.01-2021.12，58万元，在研，主持
4. 国家重点研发计划课题（2016YFC**）, 经颅血脑屏障开放/溶栓三维微泡与空化超声成像及诊疗系统,2016.07-2018.12, 80万元，已结题，主持
5. 国家自然科学基金面上项目（**），基于可控空化内皮损伤的动脉粥样硬化斑块动物模型及其活体评价，2015.01-2018.12，85万元，已结题，主持。
6. 国家自然科学基金面上项目（**），基于血管内膜超声微泡空蚀的局部可控易损斑块动物模型建立及活体评价方法，2013.01-2013.12，15万元，已结题，主持。
7. 国家973项目课题（2010CB732603），易损斑块无创、高分辨超声功能与分子定量成像，2010.01-2014.08，396万元，已结题，主要参加。
8. 国家自然科学基金面上项目（**），深部稀疏微小血管及管内单泡超宽带超声灌注成像，2008.01-2010.12，25万元，已结题，主持。
学术及科研成果、专利、论文
教材与专著
1. 万明习，宗瑜瑾，王素品，生物医学超声学，北京：科学出版社， 2010
2. 万明习，宗瑜瑾，王素品，陆明珠，生物医学超声实验，西安：西安交通大学出版社， 2010
3.Yujin Zong, Shanshan Xu, Tom Matula, Mingxi Wan, Chapter 5. Cavitation-enhanced mechanical effects and applications, in book: Cavitation in Biomedicine, Principles and Techniques, Editor: M.Wan, Y. Feng, Gail ter Haar, Springer, 2015

近五年期刊论文：
1. Dong W, Huang AQ, Huang JX, Wu PY, Guo SF, Liu HS, Qin MF, Yang XX, Zhang B, Wan MX, Zong YJ. Plasmid-loadable magnetic/ultrasound-responsive nanodroplets with a SPIO-NP dispersed perfluoropentane core and lipid shell for tumor-targeted intracellular plasmid delivery[J]. Biomaterials Science, 2020, 8 (19): 5329-5345.
2. Dong W, Wu PY, Qin MF, Guo SF, Liu HS, Yang XX, He W, Bouakaz A, Wan MX, Zong YJ. Multipotent miRNA sponge-loaded magnetic nanodroplets with ultrasound/magnet-assisted delivery for hepatocellular carcinoma therapy[J]. Molecular Pharmaceutics, 2020, 17 (8): 2891-2910. (IF=4.3).
3. Wei Dong, Pengying Wu, Di Zhou, Jixiu Huang, Mengfan Qin, Xinxing Yang, Mingxi Wan, andYujin Zong, Ultrasound-Mediated Gene Therapy of Hepatocellular Carcinoma Using Pre-microRNA Plasmid-Loaded Nanodroplets, Ultrasound in Med. & Biol., 2020, 46(1): 90-107
4. Pengying Wu, Yue Sun, Wei Dong, Huige Zhou, Shifang Guo, Lei Zhang, Xiaobing Wang*, Mingxi Wan* andYujin Zong*, Enhanced anti-tumor e?cacy of hyaluronic acid modi?ed nanocomposites combined with sonochemotherapy against subcutaneous and metastatic breast tumors, Nanoscale, 2019, 11, 11470
5. Pengying Wu, Wei Dong, Xuyan Guo, Xiaoyang Qiao, Shifang Guo, Lei Zhang,Mingxi Wan*, andYujin Zong*, ROS-Responsive Blended Nanoparticles: CascadeAmplifying Synergistic Effects of Sonochemotherapy with On-demand Boosted Drug Release During SDT Process, Adv. Healthcare Mater. 2019, 8, **
6. Shifang Guo, Xuyan Guo, Xin Wang, Di Zhou, Xuan Du, Meng Han,Yujin Zong*, Mingxi Wan*,Reduced clot debris size in sonothrombolysis assisted with phase-change nanodroplets, Ultrasonics Sonochemistry, 2019, 54:183-191
7. Shukuan Lu, Xianbo Yu, Renyan Li,Yujin Zong*, Mingxi Wan*, Passive cavitation mapping using dual apodization with cross-correlation in ultrasound therapy monitoring, Ultrasonics Sonochemistry, 2019, 54: 18-31
8. Shanshan Xu, Nan Chang, Rui Wang, Xiaodong Liu, Shifang Guo, Supin Wang,Yujin Zong*, Mingxi Wan*, Acoustic droplet vaporization and inertial cavitation thresholds and efficiencies of nanodroplets emulsions inside the focused region using a dual-frequency ring focused ultrasound, Ultrasonics Sonochemistry, 2018, 48: 532–537
9. Bai Chen, Mengling Ji, Ayache Bouakaz,Yujin Zong*, and Mingxi Wan*, Design and Characterization of an Acoustically and Structurally Matched 3-D-Printed Model for Transcranial Ultrasound Imaging, IEEE Trans on UFFC, 2018, 65(5): 741-748
10. Dui Qin, Lei Zhang, Nan Chang, Pengying Ni,Yujin Zong, Ayache Bouakaz, Mingxi Wan*, Yi Feng*, In situ observation of single cell response to acoustic droplet vaporization: Membrane deformation, permeabilization, and blebbing, Ultrasonics Sonochemistry, 2018, 47: 141–150
11. Shukuan Lu, Hong Hu, Xianbo Yu, Jiangying Long, Bowen Jing,Yujin Zong*, Mingxi Wan*,Passive acoustic mapping of cavitation using eigenspace-based robust Capon beamformer in ultrasound therapy, Ultrasonics Sonochemistry, 2018, 41: 670-679
12. Diya Wang, Mengnan Xiao, Hong Hu, Yu Zhang, Zhe Su, Shanshan Xu,Yujin Zong, Mingxi Wan, DCEUS-based focal parametric perfusion imaging of microvessel with single-pixel resolution and high contrast, Ultrasonics, 2018, 84: 392-403
13. Gao Xing, NanYang, Yuan Yuan, Gong Xue, Sun Yuanyuan, Zhou Huihui, Zong Yujin, Zhang Lijun, Yu Ming, Gas-filled ultrasound microbubbles enhance the immunoactivity of the HSP70-MAGEA1 fusion protein against MAGEA1-expressing tumours，Molecular Medicine Reports, 2018, 18(1):315-32112.
14. Xiaoping Xi,Yujin Zong, Yanghong Li, Bing Wang, Huasheng Liu, Experiment research of focused ultrasound combined with drug and microbubble for treatment of central nervous system leukemia, Oncotarget, 2018, 9(4):5424-5434
15. Shifang Guo, Aiwei Shi, Shanshan Xu, Xuan Du, Xin Wang,Yujin Zong, Ayache Bouakaz, and Mingxi Wan, Lowering of acoustic droplet vaporization threshold via aggregation, Appl. Phys. Lett., 2017, 111: 254102
16. Diya Wang,Yujin Zong, Xuan Yang, Hong Hu, Jinjin Wan, Lei Zhang, Ayache Bouakaz, Mingxi Wan, Ultrasound Contrast Plane Wave Imaging Based on Bubble Wavelet Transform:in vitroandin vivoValidations, Ultrasound in Medicine & Biology, 2016,42(7): 1584-1597
17. J. Hu^#,Y. Zong^#, J. Li, X. Zhou, J. Zhang, T. Zhu, M. Jiao, H. Su*, B. Bo*, InVitro and In Vivo Evaluation of Targeted Sunitinib-Loaded Polymer Microbubbles against Proliferation of Renal Cell Carcinoma, Journal of Ultrasound in Medicine, 2016, 35: 589-597.
18. A. Shi, P. Huang, S. Guo, L. Zhao, J. Jia,Y. Zong*, M. Wan*, Precise spatial control of cavitation erosion in a vessel phantom by using an ultrasonic standing wave, Ultrasonics Sonochemistry, 2016, 31: 163-172.
19. J. Tan, B. Pham,Y. Zong, C. Perez, D. Maris, A. Hemphill, C. Miao, T. Matula, P. Mourad, H. Wei, D. Sellers, P. Horner*, S. Pun*, Microbubbles and Ultrasound Increase Intraventricular Polyplex Gene Transfer to the Brain, Journal of Controlled Release, 2016, 231:86-93.
联系方式
电子邮箱：yjzong@xjtu.edu.cn

联系电话：-805
个人主页： http://gr.xjtu.edu.cn/web/yjzong
联系地址：西安市咸宁西路28号西安交通大学教二楼北107s室/创新港泓生楼(18号楼)3073室

更新日期：2021-03-23