一、 基本信息
姜雨，1983年生，男，二级教授，博士生导师
西北农林科技大学 动物科技学院 副院长
反刍动物遗传与进化研究中心 主任
通讯地址：陕西省杨凌农业高新技术产业示范区 邮编：712100
电子邮箱: jiangyu96@163.com; yu.jiang@nwafu.edu.cn
实验室网址：http://animal.nwsuaf.edu.cn/
工作学习经历:
2002-2006 复旦大学 生命科学院 理学学士2006-2011 中国科学院 昆明动物所 遗传学博士 2011-2013 澳大利亚联邦科学院 家畜所 博士后 2013-2015 西北农林科技大学 动物科技学院 副教授
2015-至今西北农林科技大学 动物科技学院 教授
二、 研究方向
通过分子进化和群体遗传学理论，分析农业领域在组学时代产生的海量数据，解析长期进化和人工选育过程中的关键农业性状的主效基因及分子机制。特别关注反刍类家畜，其作为陆地上最主要的草食动物，研究其能高效利用不同生态地域饲草进行前胃发酵的遗传成因，这对理解瘤胃菌群生态系统进化，通过仿生学研制人工瘤胃具有重要意义。
作为主要完成人之一，构建了世界上首个绵羊参考基因组和首个山羊参考基因组构建工作，并对世界主要肉羊品种的SNP和CNV 变异信息和频率进行了系统整理分析，构建了家畜遗传变异数据库http://animal.nwsuaf.edu.cn/，并通过系统发掘功能位点标记，作为协调人以联盟形式设计和定制了适用于中国绵羊和山羊的基因芯片，为羊的基因组选择育种服务。
通过长期研究各种牛羊基因组变异与性状关联关系，解析出构成瘤胃壁的特异基因家族和反刍动物特有的脂类合成代谢途径，部分解释了瘤胃和羊毛脂产生的遗传基础，发表在2014年的《科学》杂志。通过创新生物信息学分析方法，首次将光学图谱用于基因组组装和进行全基因组结构变异的关联分析，2013年和2015年在《自然-生物技术》杂志发表论文两篇。在2019年从遗传学角度首次提出牛羊鹿的角具有相同的细胞起源—头部神经脊干细胞，并发现鹿角利用了癌症通路和抑癌基因进行再生却不癌化，为无角牛、羊的育种提供了理论基础和关键靶基因，也为鹿角再生和癌症治疗提供了新思路，以通讯作者发表在《科学》杂志上。在2020年分别组装出首个湖羊和西农萨能奶山羊的参考基因组，并解析了世界绵羊和山羊品种的遗传来源，并在山羊上鉴定出关键的抗病基因 MUC6 ，发表在《科学-进展》和《分子生物进化》等杂志。
到目前为止在国际学术期刊发表论文30余篇，被引用1500余次。在国际学术会议做大会报告或邀请报告14次，在国内学术会议上作报告50余次。
三、参与项目和获奖
主持国家优秀青年科学基金项目“羊的基因组与分子育种”、面上项目和学校双一流学科群PI团队等科研项目。：
1. 获得2014年中国科学院“优秀博士学位论文奖”
2. 入选2015年“国家青年人才计划”项目
3. 获得2018年农业部“****农业科学家”称号
4. 获得2019年云南省“自然科学奖”一等奖（1/7）
四、10篇代表性论文
1. Zheng Z#, Wang X#, Li M#, Li Y#, Yang Z#, Wang X#, …, Chen Y*, Jiang Y*.The origin of domestication genes in goats, Science Advances (2020)
2. Cai Y#, Fu W#, Cai Da#,..., Jiang Y*, Wang X*.Ancient genomes reveal the evolutionary history and origin of cashmere producing goats in China. Molecular Biology and Evolution （2020）
3. Wang Y, Zhang C, Wang N, ,…, Jiang Y*,Wang W*, Q Qiang*. Genetic basis of ruminant headgear and rapid antler regeneration. Science, 364, eaav6335(2019)
4. Chen L#, Qiu Q#, Jiang Y#,,…,Heller R*, Wang W*. Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits. Science , 364,eaav6202 (2019)
5. Chen N#, Cai Y#, Chen Q#,...,Jiang Y*, Lei C*. Whole-genome resequencing reveals world-wide ancestry and multiple adaptive introgression events of domesticated cattle in East Asia. Nature Communications , 9 (1), 2337(2018)
6. Zhou Z#, Li M#, Cheng H#,..., Hou S*, Jiang Y*. An intercross population study reveals genes associated with body size and plumage color in ducks. Nature Communications ,9,2648(2018)
7. Wang X, Zheng Z, Cai Y, Chen T, Li C, Fu W, Jiang Y*. CNVcaller: Highly Efficient and Widely Applicable Software for Detecting Copy Number Variations in Large Populations. GigaScience , 12.4, 6(12) (2017)
8. Jiang Y#, Xie M#, Chen W#…, Wang W*, Dalrymple B*. 2014. The sheep genome illuminates biology of the rumen and lipid metabolism. Science 344 (2014): 1168-1172.
9. Zhou Z#, Jiang Y#, Wang Z#…, Wang W*, Tian Z*. Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean. Nature biotechnology 23(4): 408-414 (2015)
10. Dong Y#, Xie M#, Jiang Y#…, Wang J*, Wang W*, Sequencing and automated whole-genome optical mapping of the genome of a domestic goat. Nature Biotechnology 31(2): 135-141 (2013)
五、第一或通讯作者论文
1. Zheng Z, Wang X, Li M, Li Y, Yang Z, Wang X, …, Chen Y*, Jiang Y*.The origin of domestication genes in goats, Science Advances (2020)
2. Cai Y#, Fu W#, Cai Da#,..., Jiang Y*, Wang X*.Ancient genomes reveal the evolutionary history and origin of cashmere producing goats in China. Molecular biology and evolution （2020）
3. Jiao F#, Lou R#, Dai X#,Liu H#,…,Qian Y*, Zhao A*,Jiang Y*, Chromosome-level reference genome and population genomic analysis provide insight into the evolution and improvement of domesticated mulberry (Morus alba L), Molecular Plant （2020）
4. Sun T, Shen S, Achilli A,…,Jiang Y*, Lei C*.Genomic Analyses Reveal Distinct Genetic Architectures and Selective Pressures in Buffaloes. GigaScience . 2020 Feb 1;9(2):giz166.
5. Wang Y, Zhang C, Wang N, ,…, Jiang Y*,Wang W*, Q Qiang*. Genetic basis of ruminant headgear and rapid antler regeneration. Science, 364, eaav6335(2019)(cover story)
6. Chen L#, Qiu Q#, Jiang Y#, ,…,Heller R, Wang W. Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits. Science , 364,eaav6202 (2019) (cover story)
7. Tian X, Li R, Fu W, …, Li M*, Jiang Y*. Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data. Science China Life Sciences (2019)
8.Chen H, Liu J, Wen J, …, Song W*, Sun Q*, Jiang Y* Frequent intra- and inter-species introgression shape the landscape of genetic variation in bread wheat. Genome Biology (2019)
9.Wang Y, Gao S, ZhaoY, …, Jiang Y*.Allele-specific expression and alternative splicing in horse×donkey and cattle×yak hybrids. Zoological Research (2019) (cover story)
10. Li C, Li M, Li X, , …, Jiang Y*，Hu S*. Whole-genome resequencing reveals loci associated with thoracic vertebrae number in sheep Frontiers in Genetics 2019
11.Cao Y, Xu H, Li R, …, Luo J*, Jiang Y*. Genetic Basis of Phenotypic Differences Between Chinese Yunling Black Goats and Nubian Goats Revealed by Allele-Specific Expression in Their F1 Hybrids. Frontiers in Genetics 10:145.doi: 10.3389/fgene.2019.00145
12. Chen N, Cai Y, Chen Q,...,Jiang Y*, Lei C*. Whole-genome resequencing reveals world-wide ancestry and multiple adaptive introgression events of domesticated cattle in East Asia. Nature communications , 9 (1), 2337(2018)
13. Zhou Z, Li M, Cheng H,..., Hou S*, Jiang Y*. An intercross population study reveals genes associated with body size and plumage color in ducks. Nature communications ,9,2648(2018)
14. Wang X, Liu J, Niu Y, ..., Huang X*, Jiang Y*, Chen Y*. Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep BMC Genomics (2018), 19:397
15. Wang X, Zheng Z, Cai Y, Chen T, Li C, Fu W, Jiang Y*. CNVcaller: Highly Efficient and Widely Applicable Software for Detecting Copy Number Variations in Large Populations. GigaScience , 12.4, 6(12) (2017)
16. Dong Y, Zhang X, Xie M, …, Wang W*, Jiang Y* Reference genome of wild goat and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC Genomics (2015), 16:431
17. Chen H, Jiang Y*, Progress and Prospects in Domestic Animals and Breeding: a Review of Genomic Copy Number Variations. Biotechnology Bulletin (2015) 31(11): 35-42.
18. Li M, Zhou H, Pan X, …, Zi X*, Jiang Y*, Cassava foliage affects the microbial diversity of Chinese indigenous geese caecum using 16S rRNA sequencing[J]. Scientific Reports , 2017, 7.
19. Jiang Y#, Wang X#, Kijas J*, Dalrymple B*. Beta globin gene evolution in the ruminants: evidence for an ancient origin of sheep haplotype B. Animal Genetics (2015) 46:506–514
20. Zhou Z#, Jiang Y#, Wang Z#…, Wang W*, Tian Z*. Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean. Nature biotechnology 23(4): 408-414 (ESI Highly Cited Papers) (2015)
21. Jiang Y#, Xie M#, Chen W#…, Wang W*, Dalrymple B*. 2014. The sheep genome illuminates biology of the rumen and lipid metabolism. Science 344: 1168-1172. (ESI Highly Cited Papers) (2014)
22. Dong Y#, Xie M#, Jiang Y#…, Wang J*, Wang W*, Sequencing and automated whole-genome optical mapping of the genome of a domestic goat. Nature Biotechnology 31(2): 135-141 (ESI Highly Cited Papers) (2013)
23. Jiang Y#, Li Y#, Lee W#, … ,Zhang Y*, Wang W*, Venom gland transcriptomes of two elapid snakes ( Bungarus multicinctus and Naja atra ) and evolution of toxin genes. BMC Genomics 12(1) (2011), 1-13.
24. Li D#, Dong Y#, Jiang Y#, … ,Wang W*, A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Research 20(4),408-420. (2010)
六、在国际学术会议做邀请报告情况
1. “The progress of sheep and goat genome assembly” May 13-14, 2010, Shenzhen, China.
International Conference of 1000 Plant and Animal Reference Genomes Project
2. “Sequencing and assembly of the sheep reference genome”
Plant & Animal Genomes XIX Conference, Jan 15-19, 2011 San Diego, US.
3. “High-Resolution Analysis of Allelic Expression in Seven Sheep tissues”
Plant & Animal Genomes XIX Conference, Jan 15-19, 2011 San Diego, US.
4. “Sheep Genome Project: Gap Filling and Unbalanced Allelic Expression”
Plant & Animal Genomes XX Conference, Jan 14-18, 2012 San Diego, US.
5. “The quality of sheep reference genome, OAR v3.1”
5^th 3SR Consortium Meeting, June 28-29, Alghero, Italy
6. “A reference genome of the domestic goat”
33^rd International Society for Animal Genetics, July 15-20, 2012, Cairns, Australia
7. “The imprintome of a domestic sheep”
33^rd International Society for Animal Genetics, July 15-20, 2012, Cairns, Australia
8. “The domestic sheep reference genome assembly”
33^rd International Society for Animal Genetics, July 15-20, 2012, Cairns, Australia
9. “Detection of large-scale variation among sheep goat and cattle genomes”
34^th International Society for Animal Genetics, July 27-31, 2014, Xi'an, China
10 “Comparative genomics analysis provides new insights to ruminant biology ”
9^th International Conference on Genomics, Sep 9-12, 2014, Shenzhen, China
11. “Construction and evaluation of the Caprinae Pan-genome
3^rd Livestock genomics meeting, Sep 14-16, 2016, Cambridge, UK
12. “The ruminant biology and evolution revealed by a flock of ruminant de novo genomes”
36^th International Society for Animal Genetics, July 17-21, 2017, Dublin, Ireland
13. “world-wide ancestry and multiple adaptive introgression events of domesticated cattle”
Fossils and Ancient Genomics Symposium, Apr 17, 2018, Shenzhen, China
14. “Frequent intra- and inter-species introgression shape the landscape of genetic variation in bread wheat” PAG ASIA 2019, Jun 6-8, 2019, Shenzhen, China