一、个人基本信息
姓名: 萧飒；学位：博士；
职称：教授； 指导教师资格：博士生导师。
二、求学经历
1986-1990年北京农学院 学士
1992-1993年中国科学院研究生院在职研究生基础课学习
1996-2001年日本京都大学 博士
三、工作经历
1990-1996年 中国科学院遗传研究所，实习研究员
2002-2006年 美国纽约西奈山医学院，博士后
2007-2013年 美国马里兰大学兽医学院，研究助理
2013.09-至今 西北农林科技大学动物医学院，教授
四、研究方向
1. 新城疫病毒及其他禽副粘病毒的遗传学特性及流行病学。
2. 新城疫病毒的神经致病机理。
3. 病毒的分子致病机制。
4. 病毒与宿主的相互作用。
5. RNA病毒的反向遗传系统、诊断及疫苗的研发。
五、讲授课程
兽医传染病学；兽医流行病学；兽医传染病学实验；兽医传染病学实习；禽病专题；动物疫病防控专题；动物疫病防控与案例分析；动物疫病防控理论与实践。
六、科研项目
1. 国家自然科学基金面上项目（**；**），主持。
2. 西北农林科技大学人才引进科研启动资金。
七、发表SCI论文（近年）
1. Wang W, Chang X, Yao W, Wei N, Huo N, Wang Y, Wei Q, Liu H, Wang X, Zhang S, *Yang Z, *XiaoS. Host CARD11 inhibits Newcastle disease virus replication by suppressing viral polymerase activity in neurons. J. Virol. 2019 Sep; doi:10.1128/ JVI.01499-19
2. Bi Y, Jin Z, Wang Y, Mou S, Wang W, Wei Q, Huo N, Liu S, Wang X, Yang Z, *Chen H, *Xiao S. Identification of Two Distinct Linear B Cell Epitopes of the Matrix Protein of the Newcastle Disease Virus Vaccine Strain LaSota. Viral Immunol . 2019 Jun; 32(5): 221-229.
3. Chu Z, Gao X, Liu H, Ma J, Wang C, Lu K, Han Q, Wang Y, Wang C, Adam FEA, Wang X, Xiao S, *Yang Z. Newcastle disease virus selectively infects dividing cells and promotes viral proliferation. Vet Res . 2019 Apr 18;50(1):27.
4. Wang X, Jia Y, Wang X, Wang C, Lv C, Li X, Chu Z, Han Q, Xiao S, Zhang S, *Yang Z. MiR-375 Has Contrasting Effects on Newcastle Disease Virus Growth Depending on the Target Gene. Int J Biol Sci. 2019 Jan 1;15(1):44-57.
5. Li X, Jia Y, Liu H, Wang X, Chu Z, Hu R, Ren J, Xiao S, Zhang S, Wang X, *Yang Z. High level expression of ISG12(1) promotes cell apoptosis via mitochondrial-dependent pathway and so as to hinder Newcastle disease virus replication. Vet Microbiol. 2019 Jan;228:147-156.
6. Wang C, Chu Z, Liu W, Pang Y, Gao X, Tang Q, Ma J, Lu K, Adam FEA, Dang R, Xiao S, Wang X, *Yang Z. Newcastle disease virus V protein inhibits apoptosis in DF-1 cells by downregulating TXNL1. Vet Res . 2018 Oct 5;49(1):102.
7. Chu Z, Wang C, Tang Q, Shi X, Gao X, Ma J, Lu K, Han Q, Jia Y, Wang X, Adam FEA, Liu H, Xiao S, Wang X, *Yang Z. Newcastle Disease Virus V Protein Inhibits Cell Apoptosis and Promotes Viral Replication by Targeting CacyBP/SIP. Front Cell Infect Microbiol . 2018 Sep 3;8:304.
8. Chu Z, Ma J, Wang C, Lu K, Li X, Liu H, Wang X, Xiao S, *Yang Z. Newcastle Disease Virus V Protein Promotes Viral Replication in HeLa Cells through the Activation of MEK/ERK Signaling. Viruses . 2018 Sep 12;10(9).
9. Guo Y, Zhao J, Chang X, Yao W, Wang H, Wang W, Wang X, Zhang S, Yang Z, *Xiao S. α2,3- and α2,6-linked sialic acids are important for cell binding and replication of Newcastle disease virus in chicken primary neuronal cells. Acta Virol . 2018; 62(3): 235-245.
10. Jia YQ, Wang XL, Wang XW, Yan CQ, Lv CJ, Li XQ, Chu ZL, Adam FEA, Xiao S, Zhang SX, *Yang ZQ. Common microRNA?mRNA Interactions in Different Newcastle Disease Virus-Infected Chicken Embryonic Visceral Tissues. Int J Mol Sci . 2018 Apr 25;19(5).
11. Wang X, Wang X, Jia Y, Wang C, Tang Q, Han Q, Xiao S, *Yang Z. Coadministration of Recombinant Adenovirus Expressing GM-CSF with Inactivated H5N1 Avian Influenza Vaccine Increased the Immune Responses and Protective Efficacy Against a Wild Bird Source of H5N1 Challenge. J Interferon Cytokine Res . 2017. 37(10):467-473.
12. Wang Y, Bi Y, Yu W, Wei N, Wang W, Wei Q, Wang X, Zhang S, *Yang Z, *Xiao S. Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif "RRQRRL" are critical for fusogenic activity. Virol J . 2017. 14(1):185.
13. Wang Y, Yu W, Huo N, Wang W, Guo Y, Wei Q, Wang X, Zhang S, *Yang Z, *Xiao S. Comprehensive analysis of amino acid sequence diversity at the F protein cleavage site of Newcastle disease virus in fusogenic activity. PLoS One . 2017. 12(9):e**.
14. Fan L, Li Z, Huang J, Yang Z, Xiao S, Wang X, Dang R, *Zhang S. Dynamic distribution and tissue tropism of avian encephalomyelitis virus isolate XY/Q-1410 in experimentally infected Korean quail. Arch Virol . 2017 Nov;162(11):3447-3458
15. Ren S, Wang C, Zhang X, Zhao L, Wang X, Yao W, Han Q, Wang Y, Fan M, Gao X, Xiao S, *Wang X, *Yang Z. Phylogenetic and pathogenic characterization of a pigeon paramyxovirus type 1 isolate reveals cross-species transmission and potential outbreak risks in the northwest region of China. Arch Virol. 2017 Sep;162(9):2755-2767.
16. Kim SH, Chen Z, Yoshida A, Paldurai A, Xiao S, *Samal SK. Evaluation of fusion protein cleavage site sequences of Newcastle disease virus in genotype matched vaccines. PLoS One. 2017 Mar 24;12(3):e**.
17. Wang X, Ren S, Wang X, Wang CY, Fan M, Jia Y, Gao X, Liu H, Xiao S, *Yang Z. Genomic characterization of a wild-bird-origin pigeon paramyxovirus type 1 (PPMV-1) first isolated in the northwest region of China. 2016. Arch Virol. 2017 Mar; 162(3): 749-761.
18. Han Q, Gao X, Wu P, Xiao S, Wang X, Liu P, Tong L, Hao H, Zhang S, Dang R, *Yang Z. Re-evaluation the immune efficacy of Newcastle disease virus vaccine in commercial laying chickens. Res Vet Sci . 2017 Apr;111:63-66.
19. Ren S, Xie X, Wang Y, Tong L, Gao X, Jia Y, Wang H, Fan M, Zhang S, Xiao S, *Wang X, *Yang Z. Molecular characterisation of a Class I Newcastle disease virus strain isolated from pigeon in China. 2016. See comment in PubMed Commons below Avian Pathol. 7:1-34.
20. Kim SH, Xiao S, Collins PL, *Samal SK. LaSota F Cleavage Motif-Mediated Fusion Activity Is Affected by Other Regions of F Protein from Different Genotype Newcastle Disease Virus in a Chimeric Virus: Implication for Virulence Attenuation. 2016. J Gen Virol . doi:10.1099.
21. Gao X, Hu X, Tong L, Liu D, Chang X, Wang H, Dang R, Wang X, Xiao S, Du E, *Yang Z. Construction of a camelid VHH yeast two-hybrid library and the selection of VHH against haemagglutinin-neuraminidase protein of the Newcastle disease virus. 2016. BMC Vet Res . 12(1):39.
22. Paldurai A, Xiao S, Kim SH, Kumar S, Nayak B, Samal S, Collins PL, *Samal SK. Naturally occurring six- and twelve-nucleotide inserts do not affect Newcastle disease virus replication and pathogenesis. PLoS One. 2014 Aug 5;9(8):e103951.
23. Kim SH, Paldurai, A, Xiao S, Collins PL, *Samal SK. Modified Newcastle Disease Virus Vectors Expressing the H5 Hemagglutinin Induce Enhanced Protection against Highly Pathogenic H5N1 Avian Influenza Virus in Chickens. Vaccine. 2014 Jul 31;32(35):4428-35.
24. Liu Q, Yang Z, Hao H, Cheng S, Fan W, Du E, Xiao S, Wang X,* Zhang S. Development of a SYBR Green real-time RT-PCR assay for the detection of avian encephalomyelitis virus. J. Virol. Methods. 2014 Sep;206:46-50.
25. Paldurai A, Kim SH, Nayak B, Xiao S, Shive H, Collins PL, *Samal SK. Evaluation of the contributions of the individual viral genes to Newcastle disease virus virulence and pathogenesis. J. Virol . 2014 Aug 1;88(15):8579-8596.
26. Kim SH^#, Xiao S^#, Paldurai A, Collins PL, *Samal SK. Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus. J. Gen. Virol . 2014 Feb; 95(Pt 2):331-6. ^#Co-author.
八、联系方式
通信地址：陕西，杨凌，西农路22号，邮编712100。
电子邮箱：saxiao@nwafu.edu.cn