姓名
周友平
性别
男
出生年月

民族
汉
籍贯
湖北
最高学位
博士

职称/职务

社会兼职

联系
方式
电话

邮箱

学习及工作经历


学习
1993年，成都理工学院，地质学学士学位
1996年，中科院广州地化所，地球化学硕士学位
2006年，澳大利亚国立大学，地球科学博士学位


工作
1996-2001，华南农业大学，助教/讲师
2006-2010，澳大利亚首都特区卫生部政府实验室，分析科学家（永久职位）
2010-2012，澳大利亚柯廷大学化学系，同位素组学研究人员
2012-2013，墨尔本BAKER心脏与糖尿病研究所，代谢组学研究人员
2014-2015，德国莱布尼茨农业景观研究中心，环境蛋白组学负责人
2015-2016，中科院烟台海岸带研究所，研究员（永久职位）
2016-至今，陕西科技大学化学与化工学院，****

研究方向


利用稳定同位素比质谱学，有机质谱学，生物质谱学及核磁共振学等手段从事以下方面的研究：
1. 化学生物学（蛋白组和类脂组学）
o 利用自上而下蛋白组学手段研究高密度脂蛋白氧化修饰与动脉粥样硬化发病机理和疾病进展；
o 利用基于级联质谱的高通量脂肪组学和生物信息学手段，建立人群脂肪紊乱症、糖尿病、心血管疾病风险模型
2. 同位素组学：探索真实状态下植物类脂和碳水化合物分子生化合过程中的稳定同位素分馏机制，为进行可靠的、切入性同位素生物地球化学记录（如植物树木年轮同位素，土壤, 水体有机质同位素）解译提供理论支持
o 利用稳定同位素比质谱测定生物单个化合物自然丰度稳定同位素(¹³C, ²H, ¹⁵N)组成，探测在真实状态下植物合成类脂（如脂肪酸、蒎烯等）的生化途径和相关酶功能
o 利用定量二维核磁共振(q-2D-NMR)测定分子内特定位点氘核自然丰度，用于探测真实状态下类脂(如脂肪酸)生物合成过程中底物-产物关系；
o 发展新型稳定同位素比质谱学方法，测定碳水化合物和氨基酸分子内单个位点¹⁸O和¹⁵N同位素分布，用于环境、食品掺杂、气候、植物生理生态等方面的研究和应用；o 无机含氧阴离子如硝酸盐等多元素、多同位素分析新方法开发。
3. 稳定同位素环境蛋白质组学
o 湖泊、土壤和植物等环境蛋白质组表征方法、气候变化在湖泊、土壤和植物蛋白组水平上的记录。
o 利用P-SIF(protein-stable isotope fingerprinting)深刻理解土壤，湖泊微生物多样性在C， N，S等元素循环中的功能及对全球变化的响应。

承担项目情况
1. Large Lake Catchment Ecological and Water Security, a Sino-Germany Collaborative Research Initiative, funded by the Chinese Ministry of Science and Technology (MOST), RMB 8.6 M, Co-PI (01/2020-12/2022)
2. Organelle (compartment)-specific hydrogen isotope analysis of acetyl CoA, cellular water and fatty acids, funded by Chinese Natural Science Foundation (NSFC), RMB 0.64 M, PI (01/2020-12/2023)
3. Developing an NMR-based method for position-specific of ²H/¹H ratio measurement in natural products, funded by Chinese Natural Science Foundation (NSFC), RMB 0.69 M, PI (01/2018-12/2021)
4. Establishing a provincial centre of excellence in isotopomics in chemical biology, funded by Shaanxi Provincial Government, RMB 1 M, PI (2017-2021)
5. Establishing a university research group of Isotopomics in Chemical Biology, RMB 6 M, funded by Shaanxi University of Science & Technology, PI (07/2016-06/2021)
6. Establishing a research group of Isotope Biogeochemistry at the Yantai Institute of Coastal Zone Research, RMB 3.3 M, funded by the Chinese Academy of Sciences, PI (10/2015-09/2019), declined.

论文发表情况
33) Wang Y, Zhu ZY, Xia Y, Zhong MY, Ma R, Zhao Y, Miao Q, Wang Bo, Ma Yi, Yin XJ, *Zhou YP (2010) Novel GC/Py/IRMS-Based Method for Position-specific oxygen isotope analysis of lignin monomeric units from higher plants. Analytica Chimica Acta 1171, 338667 https://doi.org/10.1016/j.aca.2021.338667
32) H Zhang, YP Zhou, TQ Liu, XJ Yin, L Lin, DZ Wang. C4 Photosynthesis in a marine dinoflagellate Prorocentrum Donghaiense. Environmental Microbiology https://doi:10.1111/1462-2920.15545
31) X Song, YL Chen, BR Helliker, XH Tang, F Li, YP Zhou (2021) Reply to Evaristo et al.: Strong evidence for the need of correcting extraction bias in an early study of ecohydrological separation. Proceedings of the National Academy of Sciences USA 118 (17) e; https://doi.org/10.1073/pnas.
30) X Song, YL Chen, BR Helliker, XH Tang, F Li, YP Zhou (2021) Reply to Zhao: The demonstrated magnitude of artifact during stem water extraction signals a clear need for deuterium correction. Proceedings of the National Academy of Sciences USA 118 (15) e; https://doi.org/10.1073/pnas.
29) H Zhang, HK Xu, SF Zhang, YP Zhou, YB He, T Jin, W Chen, L Lin, SQ Liu, DZ Wang (2021) Efficient CO₂ assimilation and organic nutrient utilization in synergy as revealed by metaproteomics sustains a marine dinoflagellate bloom. Science of the Total Environment 768, 144515 https://doi.org/10.1016/j.scitotenv.2020.144515
28) YL Chen, BR Helliker, XH Tang, F Li, YP Zhou, X Song (2020) Stem water cryogenic extraction biases estimation in deuterium isotope composition of plant source water. Proceedings of the National Academy of Sciences USA 117 (52) 33345-33350; www.pnas.org/cgi/doi/10.1073/pnas.
27) Y Bai, QH Chen, XM Fang, YP Zhou*, CH Chen, XN Liu (2020) Terpenoids in the surface soils from different ecosystems on the Tibetan Plateau. Organic Geochemistry 150, 104125. https://doi.org/10.1016/j.orggeochem.2020.104125
26) Bo Wang, Shuai Zheng, Yan Huang, Ying Wang, Ra Ma, Yu Zhaom Xijie Yin, Jing Su, Benli Zhang, Youping Zhou* (2020) A novel GC/Py/GC/IRMS-based method for d¹⁸O and d¹⁵N measurements of nitrate and nitrite. I. Converting nitrate to benzyl nitrate for d¹⁸O analysis. Analytical Chemistry DOI: 10.1021/acs.analchem.0c01403
25) ZY Zhu, XJ Yin, X Song, B Wang, R Ma, Y Zhao, A Rani, Y Wang, J Su, A Gessler, YP Zhou* (2020) Leaf transition from heterotrophy to autotrophy is recorded in the intraleaf C, H and O isotope patterns of leaf organic matter. Rapid Communications in Mass Spectrometry DOI: 10.1002/rcm.8840
24) Ran Ma, Yu Zhao, Lan Liu, Zhenyu Zhu, Bo Wang, Ying Wang, Xijie Yin, Jing Su, Youping Zhou* (2020) Novel Position-specific ¹⁸O/¹⁶O measurement of carbohydrates. II. The complete intramolecular ¹⁸O/¹⁶O profile of the glucose unit in a starch of C4 origin. Analytical Chemistry https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b05314
23) Jing Liao, Hong Lu, Qiao Feng, Youping Zhou*, Quan Shi, Ping’an Peng, Guoying Sheng (2020) Identification of a novel undecamethyl henicosane and three oxygenated precursors in a Maoming Basin shale, China. Organic Geochemistry 141, 103974 https://doi.org/10.1016/j.orggeochem.2020.103974
22) Jinfeng Peng, Yang Yang, Youping Zhou, Charles H. Hocart, Hong Zhao, Yawei Hu, Feng Zhang (2020) Headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry with selected ion monitoring for the determination of four food flavoring compounds and its application in identifying artificially scented rice. Food Chemistry https://doi.org/10.1016/j.foodchem.2019.126136
21) Jing Liao, Xiangyun Zhang, Hong Lu, Youping Zhou*, Quan Shi, Ping'an, Peng, Guoying Sheng (2020) Two new isoprenoidal ketones related to Botryococcus braunii in the Chinese Maoming Basin. Organic Geochemistry 139: 103946. https://doi.org/10.1016/j.orggeochem.2019.103946
20) Zhenyu Zhu, Xijie Yin, Fengyan Lu, Bo Wang, Ran Ma, Yu Zhao, Ying Wang, Yi Ma, Jing Su, Charles H. Hocart, Youping Zhou* (2019) The effect of processing medium on the ²H/¹H of carbon-bound hydrogen in α-cellulose extracted from higher plants. Rapid Communications in Mass Spectrometry 2020;34:e8641. doi: 10.1002/rcm.8641
19) J Liao, H Lu, Q Feng, YP Zhou*, Q Shi, PA Peng, GY Sheng (2018) Two novel decamethyl henicosanes (C₃₁H₆₄) identified in a Maoming Basin Shale, China. Organic Geochemistry 125: 212-219. https://doi.org/10.1016/j.orggeochem.2018.09.012
18) Pedentchouk N., Zhou YP (2018) Factors Controlling Carbon and Hydrogen Isotope Fractionation During Biosynthesis of Lipids by Phototrophic Organisms. In: Wilkes H. (eds) Hydrocarbons, Oils and Lipids: Diversity, Origin, Chemistry and Fate. Handbook of Hydrocarbon and Lipid Microbiology. Springer, Cham. https://doi.org/10.1007/978-3-319-54529-5_37-1; Publisher Name: Springer, Cham; Online ISBN: 978-3-319-54529-5; eBook Packages: Biomedical and Life Sciences
17) R Ma, ZY Zhu, B Wang, Y Zhao, XJ Yin, FY Lu, Y Wang, CH Hocart, YP Zhou* (2018) Novel position-specific ¹⁸O/¹⁶O measurement of carbohydrates. I. O3 of glucose and confirmation of ¹⁸O/¹⁶O heterogeneity at natural abundance levels in glucose from starch in a C4 plant. Analytical Chemistry 90: 10293-10301. http://dx.doi.org/10.1021/acs.analchem.8b02022
16) J Liao, H Lu, Q Feng, YP Zhou*, Q Shi, PA Peng, GY Sheng (2018) Identification of a novel C₃₃-botryococcanone and C₃₃-botryococcane in the Chinese Maoming Basin. Organic Geochemistry 12: 103-111. https://doi.org/10.1016/j.orggeochem.2018.07.005
15) YP Zhou*, BL Zhang, K Grice, H Stuart-Williams, CH Hocart, Z Kayler, A Gessler, GD Farquhar (2018) On the contributions of photorespiration and compartmentation to the contrasting intramolecular ²H profiles of C₃ and C₄ plant sugars. Phytochemistry 145, 197-206. https://doi.org/10.1016/j.phytochem.2017.11.004
14) YM Wang, WQ Jiang, Q Feng, H Lu, YP Zhou*, J Liao, QT Wang, GY Shen (2017) Identification of 15-nor-cleroda-3,12-diene in a Dominican amber. Organic Geochemistry 113, 90-96. https://doi.org/10.1016/j.orggeochem.2017.08.013
13) YP Zhou*, X Yin, H Yang, J Su, H Yu, Y Wang, S Zhou, and S Zavadlav ((2017) Stable isotopic evidence for the widespread presence of oxygen-containing chemical linkages between αcellulose and lignin in Poaceae (Gramineae) grass leaves. ACS Sustainable Chemistry & Engineering 5, 3250-3260. https://doi.org/10.1021/acssuschemeng.6b03075

论文发表情况
12) YP Zhou*, K Grice, H Stuart-Williams, CH Hocart, A Gessler and GD Farquhar (2016) Hydrogen isotopic differences between C₃ and C₄ land plant lipids: consequences of compartmentation in C₄ photosynthetic chemistry and C₃ photorespiration. Plant, Cell and Environment 39, 2676-2690. https://doi.org/10.1111/pce.12821
11) ZG Chen, XJ Yin and YP Zhou (2015) Effects of GC temperature and carrier gas flow rate on on-line oxygen isotope measurement as studied by on-column CO injection. Journal of Mass Spectrometry 50, 1023-1030. https://doi.org/10.1002/jms.3617
10) ZH Alshehry, CK Barlow, JM Weir, YP Zhou, MJ McConville and PJ Meikle (2015) An efficient single- phase method for the extraction of plasma lipids. Metabolites 5, 389-403. doi: 10.3390/metabo**.
9) YP Zhou*, H Stuart-Williams, K Grice, ZE Kayler, S Zavadlav, A Vogts, F Rommerskirchen, GD Farquhar, A Gessler (2015) Allocate carbon for a reason: priorities are reflected in the ¹³C/¹²C ratios of plant lipids synthesized via three independent biosynthetic pathways. Phytochemistry 111, 14-20. https://doi.org/10.1016/j.phytochem.2014.12.005
8) YP Zhou*, Grice, K, Chikaraishi, Y, Stuart-Williams H, Farquhar, GD (2011) Temperature effect on leaf water deuterium enrichment and isotopic fractionation during leaf lipid biosynthesis: results from controlled growth of C₃ and C₄ land plants. Phytochemistry 72, 207-213. https://doi.org/10.1016/j.phytochem.2010.10.022
7) YP Zhou*, H Stuart-Williams, GD Farquhar, CH Hocart (2010) The use of natural abundance stable isotopic ratios to indicate the presence of oxygen-containing chemical linkages between a-cellulose and lignin in plant cell walls. Phytochemistry 71, 982-993. https://doi.org/10.1016/j.phytochem.2010.03.001
6) YP Zhou*, K Grice, H Stuart-Williams, GD. Farquhar, CH Hocart, H Lu, W Liu (2010) Biosynthetic origin of the saw-toothed profile in δ¹³C and δ²H of n-alkanes and systematic isotopic differences between n-, iso- and anteiso-alkanes in leaf waxes of land plants. Phytochemistry 71, 388-403. https://doi.org/10.1016/j.phytochem.2009.11.009
5) K Grice, H Lu, YP Zhou*, H Stuart-Williams, GD Farquhar (2008) Biosynthetic and environmental effects on the stable carbon isotopic compositions of anteiso- (3-methyl) and iso- (2-methyl) alkanes in tobacco leaves. Phytochemistry 69, 2807-2814. https://doi.org/10.1016/j.phytochem.2008.08.024
4) MI Bird, O Kracht, D Derrien, YP Zhou (2003) The effect of soil texture and roots on the stable carbon isotope composition of soil organic carbon. Australian Journal of Soil Research 41, 77-94. https://doi.org/10.1071/SR02044
3) MI Bird, LK Fifield, GM Santos, PB Beaumont, YP Zhou, ML di Tada, PA Hausladen (2003) Radiocarbon dating from 40 to 60 ka BP at Border Cave, South Africa. Quaternary Science Reviews 22, 943-947. https://doi.org/10.1016/S0277-3791(03)00005-2
2) CSM Turney, MI Bird, LK Fifield, AP Kershaw, RG Cresswell, GM Santos ML di Tada, PA Hausladen, YP Zhou (2001) Development of a robust ¹⁴C chronology for Lynch’s Crater (North Queensland, Australia), using different pretreatment strategies. Radiocarbon 43, 45-54. https://doi.org/10.1017/S1611
1) CSM Turney, A P Kershaw, P Moss, MI Bird, LK Fifield, RG Cresswell, GM Santos, ML Di Tada, PA Hausladen and YP Zhou (2001) Redating the onset of burning at Lynch’s Crater (North Queensland): implications for human settlement in Australia. Journal of Quaternary Science 16, 767-771. https://doi.org/10.1002/jqs.643