杨科武
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gender
男
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employeeNo
**
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310109**5
birth
1956-12-25
partyTime
1974-07-01
officeRoom
化学楼-302
phone
**
email
kwyang@nwu.edu.cn
political
群众
college
化学与材料科学学院,
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department
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nation
汉
placeOfDomicile
陕西
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highestDegreeGetFromMatherSchool":0,"passport

state
在职
researchInterests
细菌耐药性，金属蛋白（酶）化学生物学，生物技术药物
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resume
Professor Yang received his PhD in chemistry in 1994 from Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences. He joined the faculty at Fudan University as an associate professor in 1996, pursued bacterial resistance project from National Institutes of Health (NIH) at Miami University since 1998, and following serviced Girindus America Inc. at the Medicinal Chemistry Department as a senior scientist to mastermind the research and development projects from Procter and Gamble and Aventis Pharmaceuticals. Dr. Yang joined the faculty at Northwest University as a Professor and a leading investigator in Chemical Biology in 2007, also a Chair Professor at Gothenburg University, Sweden, in 2016. He is a member of SIGMA XI, The Scientific Research Society.Main Projects Accomplished* Antibiotic resistance (, ), NSFC-Swedish Research Council joint program, PI* Dual inhibition and monitoring of β-lactamases MβLs and SβLs in living bacteria (**), NSFC, PI* Activity monitoring and inhibition of metallo-β-lactamase in living bacteria cells (**), NSFC, PI* Broad-spectrum inhibition of the specific compounds against superbugs (**), NSFC, PI* Vancomycin resistance: structural optimization and activity of VanX inhibitors (**), NSFC, PI* Foreign expert fund of the National Personnel Ministry (), PI* Doctoral fund of the National Ministry of Education (5), PI* Overseas fund of the National Personnel Ministry (SLZ**), PI* Key fund for international cooperation of Shaanxi Province (2014KW23-03), PI* Key fund for international cooperation of Shaanxi Province (2010KW-16), PI* Shaanxi Province Natural Science Fund (2009JM2002), PI* Research fund of Shaanxi Province Department of HRSS (), PI* Research fund of Shaanxi Province Department of Education (09JK786), PI* Development of pro-drugs for the treatment of osteoporosis, Procter & Gamble, PI* Synthetic development of the anti-herpes compounds, Aventis Pharmaceuticals, PI* Characterization of metallo-β-lactamases, National Institutes of Health (NIH), co-PI* Inhibition of metallo-β-lactamases from X. maltophilia, National Institutes of Health (NIH), co-PI* Inhibition studies on d-ala-d-ala dipeptidase VanX, National Science Foundation (NSF), co-PI* Studies on glyoxalase II in arabidopsis thaliana, National Science Foundation (NSF), co-PIInternational Collaboration* Characterization of metallo-β-lactamases: Professor Michael Crowder, Miami University, USA* Antibiotic resistance in bacteria: Professor Mate Erdelyi, University of Gothenburg, Sweden* Binding and mechanism: Professor Peter Oelschlaeger, Western University of Health Sciences, USA* EPR characterization: Professor Brian Bennett, The National Biomedical EPR Center, USA* Crystal structure of metallo-β-lactamase: Professor James Spencer, University of Bristol, UK* Structure of MβL-inhibitor complexe: Dr. Hanna-Kirsti Leiros, Arctic University of NorwaySelected Publications105. HH Ding, MH Zhao, L Zhai, JB Zhen, LY Sun, JZ Chigan, C Chen, JQ Li, H Gao, KW Yang*, \"Quinine-based quaternized polymer: A potent scaffold with bactericidal properties without resistance\", Polymer Chemistry, 2021, doi:10.1039/D0PY01751E.104. JQ Li, H Gao, L Zhai, LY Sun, C Chen, JZ Chigan, HH Ding, KW Yang*, \"Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases\", Bioorg. Med. Chem., 2021, accepted.103. Y Ge, LW Xu, JB Zhen, C Chen, M Lv, JP Su, KW Yang*, Cheng-Cheng Liu*, \"A degradation product from hydrolysate of imipenem with ImiS broad-spectrum inhibits metallo-β-lactamases\",Jund. J. Microb., 2021, accepted.102. C Chen, KW Yang*, LY Wu, JQ Li, LY Sun, \"Disulfiram as a potent metallo-β-lactamase inhibitor with dual functional mechanisms\", Chem. Commun., 2020, 56, 2755-2758.101. C Chen?, Y Xiang?, KW Yang*, YJ Zhang, WM Wang, JP Su, Y Ge, Y Liu, \"A protein structure-guided covalent scaffold selectively targets the B1 and B2 subclass metallo-β-lactamases\", Chem. Commun., 2018, 54, 4802-4805.100. KW Yang?*, YJ Zhou?, Y Ge, YJ Zhang, \"Real-time activity monitoring of New Delhi metallo-β-lactamase-1 in living bacterial cells by UV-Vis spectroscopy\", Chem. Commun., 2017, 53, 8014-8017.99. XY Ouyang?*, YN Chang?, KW Yang?*, WM Wang, JJ Bai, JW Wang, YJ Zhang, SY Wang, BB Xie, LL Wang, \"A DNA nanoribbon as a potent inhibitor of metallo-β-lactamases\", Chem. Commun., 2017, 53, 8878-8881. 98. C Chen and KW Yang*, \"Structure-based design of covalent inhibitors targeting metallo-β-lactamases\", Eur. J. Med. Chem., 2020, 203, 112573.97. C Chen, LY Sun, H Gao, PW Kang, JQ Li, JB Zhen, KW Yang*, \"Identification of cisplatin and palladium(II) complexes as potent metallo-β-lactamases inhibitors for targeting carbapenem-resistant Enterobacteriaceae (CRE)\", ACS Infect. Dis., 2020, 6, 975-985.96. C Chen and KW Yang*, \"Ruthenium complex as prospective inhibitor of metallo-β-lactamases to reverse carbapenem resistance\", Dalton Trans., 2020, 49, 14099-14105.95. Y Xiang, YJ Zhang, Y Ge, YJ Zhou, C Chen, WX Yuan Wahlgren, XS Tan, X Chen, KW Yang*, \"Kinetic, thermodynamic, and crystallographic studies of 2-triazolylthioacetamides as Verona Integron-Encoded metallo-β-lactamase 2 (VIM-2) inhibitor\", Biomolecules, 2020, 10, 72. 94. JB Zhen, PW Kang, MH Zhao, KW Yang*, \"Silver nanoparticle conjugated star PCL-b-AMPs copolymer as nanocomposite exhibits efficient antibacterial properties\", Bioconjugate Chem., 2020, 319, 51-63.93. JQ Li, C Chen, M Yao, LY Sun, H Gao, JZ Chigan, KW Yang*, \"Hydroxamic acid with benzenesulfonamide: an effective scaffold for the development of broad-spectrum metallo-β-Lactamase inhibitors\", Bioorg. Chem., 2020, 105, 104436.92. PW Kang?, JP Su?, LY Sun, H Gao, KW Yang*, \"3-Bromopyruvate as a potent covalently reversible inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1)\", Eur. J. Pharm. Sci., 2020, 142, 105161. 91. YX Li?, JB Zhen?, Q Tian, CQ Shen, LB Zhang, KW Yang, L Shang*, \"One step synthesis of positively charged gold nanoclusters as effective antimicrobial nanoagents against multidrug-resistant bacteria and biofilms\", J. Colloid. Interf. Sci., 2020, 569, 235-243. 90. JB Zhen, MH Zhao, Y Ge, Y Liu, LW Xu, C Chen, YK Gong, KW Yang*, \"Construction, mechanism and antibacterial resistance insight of the polypeptide-based nanoparticles\", Biomater. Sci., 2019, 7, 4142-4152.89. Y Ge?, LW Xu?, Y Liu, LY Sun, H Gao, JQ Li, KW Yang*, \"Dithiocarbamate as a valuable scaffold for the inhibition of metallo-β-Lactmases\", Biomolecules, 2019, 9, 699. 88. YJ Zhang?, WM Wang?, P Oelschlaeger, C Chen, JE Lei, M Lv, KW Yang*, \"Real-time monitoring of NDM-1 activity in live bacterial cells by isothermal titration calorimetry: a new approach to measure inhibition of antibiotic-resistant bacteria\", ACS Infect. Dis., 2018, 4, 1671-1678. 87. MH Zhao?, JB Zhen?, KW Yang*, Y Liu, JQ Li, SQ Shi, \"Quaternized polymer-based nanostructures confer antimicrobial efficacy against multidrug-resistant bacteria\", New J. Chem., 2020, 44, 3874-3881. 86. Y Liu, C Chen, LY Sun, H Gao, JB Zhen, KW Yang*, \"Meta-substituted benzenesulfonamide: a potent scaffold for the development of metallo-β-lactamase ImiS inhibitors\", RSC Med. Chem., 2020, 11, 259-267.85. YL Zhang*, Y Yan, XJ Wang, KW Yang, \"Synthesis and bioactivity of thiazolethioacetamides as potential metallo-β-lactamase inhibitors\", Antibiotics, 2020, 9, 99.84. YJ Zhang, L Zhai, Y Wan, KW Yang*, \"Triazolylthioacetamides confer inhibitory efficacy against metallo-β-Lactamase IMP-1\", Lett. Drug. Des. Discov., 2020, 17, doi: 10.2174/**019.83. H Gao, Y Ge, MH Jiang, C Chen, LY Sun, JQ Li, KW Yang*,\"Real-time monitoring and inhibition of carbapenemase activity in live bacterial cells: application to screening of ?-lactamase inhibitors\", New J. Chem., 2020, doi: 10.1039/D0NJ03475D.82. Y Ge?, PW Kang?, JQ Li, H Gao, LY Sun, C Chen, KW Yang*, \"Thiosemicarbazones exhibit inhibitory efficacy against New Delhi metallo-β-lactamase-1 (NDM-1)\", J. Antibiot., 2020, accepted.81. XR Wei, K Ma, YB Cheng, LY Sun, DJ Chen, XL Zhao, H Lu, BT Song, KW Yang, PX Jia*, \"Adhesive, conductive, self-healing, and antibacterial hydrogel based on chitosan-polyoxometalate complexes for wearable strain sensor\", ACS Appl. Polym. Mater. 2020, 2, 2541-2549.80. H Andersson, P Jarvoll, SK Yang, KW Yang, Máté Erdély*, \"The binding mode of 2-(triazolylthio)acetamides to metallo-β-lactamase CcrA\", ACS Omega. 2020, doi: 10.1021/acsomega.0c02187.79. C Chen and KW Yang*, \"Ebselen bearing polar functionality: identification of potent antibacterial agents against multidrug-resistant Gram-negative bacteria\", Bioorg. Chem., 2019, 93, 103286. 78. JP Su, JY Liu, C Chen, YJ Zhang, KW Yang*, \"Ebsulfur as a potent scaffold for inhibition and labelling of New Delhi metallo-β-lactamase-1 in vitro and in vivo\", Bioorg. Chem., 2019, 84, 192-201.77. C Chen, Y Liu, YJ Zhang, Y Ge, JE Lei, KW Yang*, \"The assemblage of covalent and metal binding dual functional scaffold for cross-class metallo-β-lactamases inhibition\", Future Med. Chem., 2019, 11, 2381-2394.76. M Lv, YJ Zhang, F Zhou, Y Ge, MH Zhao, Y Liu, KW Yang*, \"Real-time monitoring of D-Ala-D-Ala dipeptidase activity of VanX in living bacteria by isothermal titration calorimetry\", Anal. Biochem., 2019, 578, 29-35.75. YL Zhang*, Y Yan, LF Liang, J Feng, XJ Wang, L Li, KW Yang, \"Halogen-substituted triazolethioacetamides as a potent skeleton for the development of metallo-β-lactamase inhibitors\", Molecules, 2019, 24, 1174. 74. Y Zhao, JL Wen, Y Ge, XT Zhang, H Shi, KW Yang, X Gao, SQ Shi*, YK Gong, \"Fabrication of stable biomimetic coating on PDMS surface: cooperativity of multivalent interactions\", Appl. Surf. Sci., 2019, 469, 720-730.73. YJ Zhang, XL Liu, WM Wang, C Chen, MH Zhao, KW Yang*, \"Amino acid thioesters exhibit inhibitory activity against B1-B3 subclasses of metallo-β-lactamases\", Chem. Pharm. Bull., 2019, 67, 135-142. 72. XL Liu?, Y Xiang?, C Chen, KW Yang*, \"Azolylthioacetamides as potential inhibitors of New Delhi metallo-β-lactamase-1 (NDM-1)\", J. Antibiot., 2019, 72, 118-121.71. Y Xiang?, C Chen?, WM Wang, LW Xu, KW Yang*, P Oelschlaeger, Y He, \"Rhodanine as a potent scaffold for the development of broad-spectrum metallo-β-lactamase inhibitors\", ACS Med. Chem. Lett., 2018, 9, 359-364.70. C Chen?, Y Xiang?, Y Liu, XD Hu, KW Yang*, \"Mercaptoacetate thioesters and their hydrolysate mercaptoacetic acid jointly inhibit metallo-β-Lactamase L1\", MedChemComm., 2018, 9, 1172–1177. 69. T Yu, X Shu, KW Yang, XD Hu*, \"Biomimetic total synthesis of Scabellone B\", Synlett., 2018, 29, 1617-1621.68. Q Wang?, Y He?*, R Lu, WM Wang, KW Yang, HM Fan, Y Jin, GM Blackburn, \"Thermokinetic Profile of NDM-1 and Its Inhibition by Small Carboxylic Acids\", Bioscience Rep., 2018, 38(2). 67. YN Chang, Y Xiang, YJ Zhang, WM Wang, C Chen, P Oelschlaeger, KW Yang*, \"Carbamylmethyl mercaptoacetate thioether: a novel scaffold for the development of L1 metallo-β-lactamase inhibitors\", ACS Med. Chem. Lett. 2017, 8, 527-532.66. Y Xiang, YN Chang, Y Ge, JS Kang, YL Zhang, XL Liu, P Oelschlaeger, KW Yang*, \"Azolylthioacetamides as a potent scaffold for the development of metallo-β-lactamase inhibitors\", Bioorg. Med. Chem. Lett. 2017, 27, 5225-5229.65. Y Ge, YJ Zhou, KW Yang*, YL Zhang, Y Xiang, YJ Zhang, \"Real-time activity assays of β-lactamases in living bacterial cells: application to the inhibition of antibiotic-resistant E. coli strains\", Mol. BioSyst., 2017, 13, 2323-2327.64. WJ Wang, Q Wang, Y Zhang, R Lu, YL Zhang, KW Yang*, JE Lei, Y He*, \"Characterization of beta-lactamase activity using isothermal titration calorimetry\", BBA-Gen. Subjects, 2017, 1861, 2031-2038.63. YL Zhang, YJ Zhang, WM Wang, KW Yang*, \"Synthesis and inhibitory activity of acetamidephosphonic acids against metallo-β-lactamases\", Phosphorus Sulfur, 2017, 192, 14-18.62. L Zhai?, YL Zhang?, JS Kang, P Oelschlaeger, L Xiao, SS Nie, KW Yang*, \"Triazolylthioacetamide: a valid scaffold for the development of New Delhi metallo-β-lactmase-1 (NDM-1) inhibitors\", ACS Med. Chem. Lett. 2016, 7, 413-417.61. T Christopeit, KW Yang, SK Yang, HKS Leiros*, \"The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor\", Acta Crystallogr. F, 2016, 72, 813-819. 60. XL Liu, KW Yang*, YJ Zhang, Y Ge, Y Xiang, YN Chang, P Oelschlaege, \"Optimization of amino acid thioesters as inhibitors of metallo-β-lactamase L1\", Bioorg. Med. Chem. Lett. 2016, 26, 4698-4701.59. LL Zhou, YQ Zhou, YL Tang, KW Yang, L Zhang, LX Gao, GF Zhang, ZW Gao*, WQ Zhang*, \"Antibacterial fischer carbenoid CO-releasing molecules (Fc-CORMs)\", Chin. J. Org. Chem. 2016, 36, 2695-2703.58. XL Liu, Y Shi, JS Kang, P Oelschlaeger, KW Yang*, \"Amino acid thioester derivatives: a highly promising scaffold for the development of metallo-β-lactamase L1 inhibitors\", ACS Med. Chem. Lett. 2015, 6, 660–664.57. L Zhai and KW Yang*, “Porphyrin-vancomycin: a highly promising conjugate for the identification and photodynamic inactivation of antibiotic resistant Gram-positive pathogens\", Dyes and Pigments, 2015, 120, 228-238. 56. SK Yang, JS Kang, P Oelschlaeger, KW Yang*, “Azolylthioacetamide: a highly promising scaffold for the development of metallo-β-lactamase inhibitors\", ACS Med. Chem. Lett., 2015, 6, 455-460. 55. YL Zhang, KW Yang*, YJ Zhou, AE LaCuran, P Oelschlaeger, MW Crowder, \"Diaryl-substituted Azolylthioacetamides: Inhibitor Discovery of New Delhi Metallo-β-Lactamase-1 (NDM-1)\", ChemMedChem., 2014, 9, 2445-2448. 54. X Yang, YJ Zhou, P He, YH Guo, CJ Liu, KW Yang*, \"Activation free energy of Zn(II), Co(II) binding to metallo-β-lactamase ImiS\", Chi. Chem. Lett., 2014, 25, 1323-1326. 53. KW Yang*, L Feng, SK Yang, M Aitha, AE LaCuran, P Oelschlaeger, MW Crowder*, \"New β-phospholactam as a carbapenem transition state analog: synthesis of a broad-spectrum inhibitor of metallo-β-lactamases\", Bioorg. Med. Chem. Lett. 2013, 23, 5855-5859.52. CC Liu, L Zhai, Y Shi, KW Yang*, \"Purification of metallo-β-lactamase CcrA from Bacteroides fragilis with salting-out method\", Braz. Arch. Biol. Technol., 2013, 56, 811-816.51. Y Shi, L Feng, Q Yang, YJ Zhou, Y Xiang, KW Yang*, \"Thermokinetic evaluation of pyrrolidinedicarboxylic acid inhibiting cefalexin hydrolysis with metallo-β-lactamase L1 from Stenotrophomonas maltophilia\", Thermochim. Acta, 2013, 563, 46-50.50. YL Zhang, JM Xiao, JL Feng, KW Yang*, L Feng, LS Zhou，MW Crowder*, \"A novel fluorogenic substrate for dinuclear Zn(II)-containing metallo-β-lactamases\", Bioorg. Med. Chem. Lett. 2013, 23, 1676-1679.49. L Zhai, LS Zhou, CC Liu, Y Shi, YJ Zhou, KW Yang*, \"Determination of thermodynamic parameters of benzylpenicillin hydrolysis by metallo-β-lactamase CcrA from Bacteroides fragilis\", Thermochim. Acta, 2013, 556, 54-57.48. LS Zhou, KW Yang*, L Feng, JM Xiao, CC Liu, YL Zhang, MW Crowder*, \"Novel fluorescent risedronates: synthesis, photodynamic inactivation and imaging of Bacillus subtilis\", Bioorg. Med. Chem. Lett. 2013, 23, 949-954.47. CC Liu, LS Zhou, JY Liu, JM Xiao, HZ Gao, KW Yang*, \"Photoinactivation of vancomycin-resistant Enterococci and Bacillus subtilis by a novel norvancomycin-rhodamine B conjugate\", New J. Chem. 2013, 37, 575-580. 46. JM Xiao, L Feng, LS Zhou, HZ Gao, YL Zhang, KW Yang*, \"Novel fluorescent cephalosporins: synthesis, antimicrobial activity and photodynamic inactivation of antibiotic resistant bacteria\", Eur. J. Med. Chem. 2013, 59, 150-159. 45. CC Liu, XB Zhao, KW Yang*, KZ Xu, L Zhai, X Yang, HZ Gao, \"Exploring antibiotic resistance based on enzyme hydrolysis by microcalorimetry IV: determination of thermokinetic parameters of d-ala-d-ala hydrolysis with dipeptidase VanX\", J. Therm. Anal. Calorim. 2013, 111, 1663-1667. 44. L Zhai, KW Yang*, CC Liu, KZ Xu, X Yang, HZ Gao, Y Shi, L Feng, C Jia, LS Zhou, JM Xiao, \"Exploring antibiotic resistance based on enzyme hydrolysis by microcalorimetry Ⅲ: determination of thermokinetic parameters of cefazolin hydrolysis with metallo-β-lactamase CcrA\", J. Therm. Anal. Calorim. 2013, 111, 1657-1661.43. L Feng, KW Yang*, LS Zhou, JM Xiao, X Yang, L Zhai, YL Zhang, MW Crowder*, \"N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with Co-antibacterial effect against antibiotic-resistant bacteria\", Bioorg. Med. Chem. Lett. 2012, 22, 5185-5189. 42. L Zhai, KW Yang*, CC Liu, HZ Gao, X Yang, Y Shi, J Wen, \"Thermokinetic characterization of imipenem hydrolysis with metallo-β-lactamase CcrA from Bacteroides fragilis\", Thermochim. Acta, 2012, 539, 67-70. 41. C Jia, KW Yang*, CC Liu, L Feng, JM Xiao, LS Zhou, YL Zhang, \"Synthesis, characterization and activity of new phosphonate dipeptides as potential inhibitors of VanX\", Bioorg. Med. Chem. Lett. 2012, 22, 482-484. 40. X Yang, L Feng, KZ Xu, HZ Gao, C Jia, CC Liu, JM Xiao, L Zhai, LS Zhou, KW Yang*, \"Exploring antibiotic resistant mechanism by microcalorimetry II: determination of thermokinetic parameters of imipenem hydrolysis with metallo-β-lactamase ImiS\", J. Therm. Anal. Calorim., 2012, 110, 945-948. 39. HZ Gao, Q Yang, XY Yan, ZJ Wang, JL Feng, X Yang, SL Gao, L Feng, X Cheng, C Jia, KW Yang*, \"Exploring antibiotic resistant mechanism by microcalorimetry determination of thermokinetic parameters of metallo-β-lactamase L1 catalyzing penicillin G hydrolysis\", J. Therm. Anal. Calorim., 2012, 107, 321-324. 38. HZ Gao and KW Yang*, \"Advances in the study of metallo-β-lactamases as drug-resistant target enzymes in superbugs\", Chin. Pharm. J., 2012, 47, 325-330. 37. HZ Gao, KW Yang*, XL Wu, JY Liu, L Feng, JM Xiao, LS Zhou, C Jia, Z Shi, \"Novel conjugation of norvancomycin-fluorescein for photodynamic inactivation of Bacillus subtilis\", ACS Bioconjugate Chem., 2011, 22, 2217-2221.36. KW Yang*, X Cheng, C Zhao, CC Liu, C Jia, L Feng, JM Xiao, LS Zhou, HZ Gao, X Yang, L Zhai, \"Synthesis and activity study of phosphonamidate dipeptides as potential inhibitors of VanX\", Bioorg. Med. Chem. Lett., 2011, 21, 7224-7227.35. XP Zhao, JH Zhan, XX Yan, KW Yang*, \"Advances in the study of bisphosphonates\", Chin. J. Osteoporos, 2011, 17, 917-921. 34. XY Yan, HZ Gao, JL Feng, X Yang, L Feng, X Cheng, C Jia, KW Yang*, \"Spectral characterization and kinetic study of WT-L1 and Co(II)-L1 catalyzing hydrolysis of β-lactam antibiotics\", Chin. Antibiotic. J., 2011, 36, 388-393. 33. JL Feng, X Yang, XY Yan, HZ Gao, L Feng, X Cheng, C Jia, D Wu, KW Yang*, \"Kinetic study on expression and purification of ImiS and catalyzing three group of β-lactams\", Chin. Antibiotic. J., 2011, 36, 197-200. 32. X Cheng, JL Feng, L Feng, KW Yang*, \"Synthesis and activity determination of Nitrocefin as MβLs test reagent\", J. Northwest Uni. (Nat. Sci.), 2010, 40, 22-25. 31. C Zhao, XY Yan, JL Feng, X Cheng, KW Yang*, \"Synthesis and characterization of anti-osteoporosis drug sodium risedronate and its metal complex\", J. Northwest Uni. (Nat. Sci.), 2010, 8, 1-7. 30. C Zhao, XY Yan, JL Feng, X Cheng, KW Yang*, \"Advances in the study of bisphosphonates anti-osteoporosis drugs\", J. Northwest Uni. (Nat. Sci.), 2010, 40, 147-149. 29. AL Costello, NP Sharma, KW Yang, MW Crowder*, DL Tierney, \"X-ray absorption spectroscopy of the zinc-binding sites in the class B2 metallo-β-lactamase ImiS from Aeromonas veronii bv. sobria\", Biochemistry, 2006, 45, 13650-13658.28. NP Sharma, C Hajdin, S Chandrasekar, B Bennett, KW Yang, MW Crowder*, \"Mechanistic studies on the mononuclear Zn(II)-containing metallo-β-lactamase ImiS from Aeromonas sobria\", Biochemistry, 2006, 45, 10729-10738. 27. AL Costello, G Periyannan, KW Yang, MW Crowder*, DL Tierney, \"Site selective binding of Zn(II) to metallo-β-lactamase L1 from Stenotrophomonas Maltophilia\", J. Biol. Inorg. Chem., 2006, 11, 351-358. 26. GR Periyannan, AL Costello, DL Tierney, KW Yang, B Bennett, MW Crowder*, \"Sequential binding of cobalt(II) to metallo-β-lactamase CcrA\", Biochemistry, 2006, 45, 1313-1320. 25. KW Yang, FC Golich, TK Sigdel, MW Crowder*, \"Phosphinate, sulfonate and sulfonamidate dipeptides as potential inhibitors of aminopeptidase N\", Bioorg. Med. Chem. Lett., 2005, 15, 5150-5153. 24. PA Crawford, KW Yang, N Sharma, B Bennett, MW Crowder*, \"Spectroscopic studies on Co(II)-substituted metallo-β-lactamase ImiS from Aeromonas veronii bv. sobria\", Biochemistry, 2005, 44, 5168-5176. 23. GPK Marasinghe, IM Sander, B Bennett, G Periyannan, KW Yang, CA Makaroff, MW Crowder*, \"Structural studies on a mitochondrial glyoxalase II\", J. Biol. Chem., 2005, 280, 40668-40675. 22. KW Yang and MW Crowder*, \"A method for removing ethylenediaminetetraacetic acid from apo-proteins\", Anal. Biochem., 2004, 329, 342-344. 21. KW Yang, DN Sobieski, AL Carenbauer, PA Crawford, CA Makaroff, MW Crowder*, \"Explaining the inhibition of glyoxalase II by 9-Fluorenylmethoxycarbonyl-protected glutathione derivatives\", Arch. Biochem. Biophys., 2003, 414, 271-278. 20. MW Crowder*, KW Yang, AL Carenbauer, G Periyannan, ME Seifert, NE Rude, TR Walsh, \"The problem of a solvent exposable disulfide when preparing Co(II)-substituted metallo-β-lactamase L1 from Stenotrophomonas maltophilia\", J. Biol. Inorg. Chem., 2001, 6, 91-99. 19. MW Crowder*, KW Yang, JJ Brandt, LL Chatwood, FC Golich, LA Detar, LR Herron, \"Mechanistic and inhibition studies on VanX: the d-d-dipeptidase required for high level vancomycin resistance\", Abs. Pap. Am. Chem. Soc., 2001, 222, 197-INOR part 1.18. KW Yang, JJ Brandt, LL Chatwood, MW Crowder*, \"Phosphonamidate and phosphothioate dipeptides as potential inhibitors of VanX\", Bioorg. Med. Chem. Lett., 2000, 10, 1085-1087. 17. KW Yang and MW Crowder*, \"Inhibition studies on the metallo-β-lactamase L1 from Stenotrophomonas Maltophilia\", Arch. Biochem. Biophys., 1999, 368, 1-6. 16. JJ Brandt, LL Chatwood, KW Yang, MW. Crowder*, \"Continuous assay for VanX, the d-ala-d-ala dipeptidase required for high-level vancomycin resistance\", Anal. Biochem., 1999, 272, 94-99. 15. MW. Crowder*, S McM-Munoz, AL Carenbauer, M Seifert, KW Yang, \"Structure/function studies on metal-β-lactamase L1 from S. maltophilia\", J. Inorg. Biochem., 1999, 74, 106. 14. KW Yang, YZ Wang, ZX Huang*, J Sun, \"Active site model of carbonic anhydrase: synthesis and crystal structure of functional tetrahedral zinc complex with hydrotris(3-phenyl-5-methylpyrazol-1-yl)borate\", Polyhedron, 1997, 16, 109-112. 13. KW Yang, YZ Wang, ZX Huang*, J Sun, \"Synthesis, characterization and x-ray crystal structure of Zn(II) complex with poly-nitrogen ligand [(3-HB(3,5-Me2pz)3]2Zn2C6H5CH3\", Polyhedron, 1997, 16, 1297-1300. 12. KW Yang*, YQ Yin, YZ Wang, ZX Huang, \"Studies on synthesis, characterization and quantum chemistry of carbonic anhydrase active site model compounds [(3-HB(3-Phpz)3ZnX] (X = Cl, Br, I and NO3)\", Acta Chimia Sinica, 1997, 55, 209-214. 11. KW Yang*, YQ Yin, ZX Huang, YH Wang, \"Synthesis and crystal structure of zinc complex [Zn(P(py)3)2][Zn(NCS)4(MeCN)]\", Polyhedron, 1996, 15, 79-81. 10. KW Yang, YQ Yin*, DS Jin, \"An active site model for carbonic anhydrase-synthesis and crystal structure of [(3-HB(3-Phpz)3]ZnBr\", Polyhedron, 1995, 14, 1021-1023. 9. KW Yang, YQ Yin*, DS Jin, \"Preparation of copper(I) complexes with novel pyrazolyl borates\", Chi. Chem. Lett., 1994, 5, 341-342.8. KW Yang, JG Wu, LF Wang*, ZY Yang, \"Determination of stability constants of rare earth(III) complexes by hypersensitive transition method\", J. Lanzhou Uni. (Nat. Sci.), 1994, 30, 49-52.7. KW Yang, LF Wang*, JG Wu, F Dong, \"Synthesis, characterization and antioxidative activity of new vitamin B6 triethanolamine rare earth(III) complexes\", J. Inorg. Biochem., 1993, 52, 145-150. 6. KW Yang, LF Wang*, JG Wu, ZY Yang, G Xiang, \"Synthesis, characterization and antioxidative activity of vitamin B6 rare earth(III) complexes\", J. Inorg. Biochem., 1993, 52, 151-155. 5. KW Yang, JG Wu, LF Wang*, F Dong, \"Determination of stability constants of Nd(III) complexes with pantothenate by absorption spectroscopy\", Chi. J. Inorg. Chem., 1993, 9, 271-274.4. ZY Yang, LF Wang*, JG Wu, KW Yang, Y Zhu, \"Studies on synthesis, characterization and electrical conductivity of complexes of 3d transition metal with 2-oxo-propionic acid (4-pyridinecarbonyl)hydrazone\", Acta Chimia Sinica, 1993, 51, 184-190.3. LF Wang*, KW Yang, JG Wu, \"Determination of thermodynamical functions of neodymium pyridoxol complexes by hypersensitive transition method\", Chi. J. Appl. Chem., 1993, 10, 84-86.2. ZY Yang, J Ai, LF Wang*, JG Wu, KW Yang, \"Studies on the synthesis characterization and antitumor activity of the temary complexes of rare earth(III) with schiff base\", J. Lanzhou Uni. (Nat. Sci.), 1993, 29, 162-166.1. ZY Yang, LF Wang*, JG Wu, XY Li, KW Yang, Q Wu, \"Studies on anticancer activity of some rare earth (III) complexes with schif base\", Chi. Sci. Bull., 1992, 9, 813-816.
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nativePlace
陕西西安"