张健健
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zhangjianjian
gender
男
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000000
birth
0002-11-30
partyTime
2009-07-09
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532
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**
email
zhangjj@nwu.edu.cn
political
中共党员
college
化学与材料科学学院,
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汉
placeOfDomicile
西安
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state
在职
researchInterests
荧光，光声成像； 近红外有机小分子探针设计；
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2035-10-16
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resume
张健健，博士，副教授，硕导。2010年本科毕业于中国矿业大学化学工程与工艺系，同年被保送到兰州大学有机化学专业，导师彭羽教授。并以硕博连读形式攻读分析化学博士学位，导师张海霞教授。2016年3月至2017年8月在新加坡南洋理工大学浦侃裔副教授处做博士后研究。2017年8月至今在西北大学化学与材料科学学院任教。迄今为止在Advanced Materials, Analytical Chemistry, Chemical Communications, Organic&Biomolecular Chemistry等国际著名期刊及分析化学类权威期刊以第一作者身份发表9篇，其中Bioconjugate Chemistry及Chemical Science综述各一篇。2017年获中国分析测试协会科学技术奖三等奖（第二名）。目前主持国家自然科学基金青年项目。担任Research And Application Of Materials Science期刊编委 　　欢迎对本课题组感兴趣的同学报考！ 　　联系地址：化学与材料科学学院532室zhangjj@nwu.edu.cn入职后发表文章37. Fang Yuan,# Yang Li,# Zhenjuan Chen,# Jianjian Zhang*, Lulu Ning,* Xiaofeng Yang*, Kanyi Pu*. Excimer-based Activatable Fluorescent Sensor for Sensitive Detection of Alkaline Phosphatase, Chemical Research in Chinese Universities, 2021, accepted.36. Lei Wu, Yongqin Shi, Hanjie Yu, Jianjian Zhang, Zheng Li, Xiao-Feng Yang, Bromination-induced spirocyclization of rhodamine dyes affording a FRET-based ratiometric fluorescent probe for visualization of hypobromous acid (HOBr) in live cells and zebrafish, Sensors and Actuators B: Chemical, 2021, DOI: 10.1016/j.snb.2021.129790. 35. Xinyue, Zhao; Lulu,Ning; Xiaoman, Zhou; Zhihui,Song; Jianjian, Zhang*; Feng,Guan; Xiaofeng,Yang, An Activatable Near-Infrared Fluorescence Hydrogen Sulfide (H2S) Donor for Imaging H2S Release and Inhibiting Inflammation in Cells, Analytical Chemistry, 2021, DOI.org/10.1021/acs.analchem.0c05081.34.Jianjian Zhang,* Lulu Ning, Ziling Zeng, Kanyi Pu,* Development of NIR-II Photoacoustic Imaging Agents, Trends in Chemistry, 2021, Doi.org/10.1016/j.trechm.2021.01.002 (Review) 33. 张素雅，张健健* 光气检测用小分子荧光探针的研究进展，《精细化工》, 2020, 37(11), 2229-2237. （综论） 32. Yang Li, Lulu Ning, Fang Yuan, Tian Zhang, Jianjian Zhang,* Zhigang Xu,* and Xiaofeng Yang,* Activatable Formation of Emissive Excimers for Highly Selective Detection of β-Galactosidase. Analytical Chemistry, 2020, 92, 8, 5733–5740. 　　31.Jianjian Zhang,*Lulu Ning,Jiaguo Huang,Chi Zhang,and Kanyi Pu,*Activatable Molecular Agents for Cancer Theranostics.Chemical Science, 2020, 11, 618-630. [Invited Perspective]　　30.Xinli Li,Zhiying Niu,Zhenfeng Lin,Yuan Qin,Jingxi Xu,Huayu Huang*Liancheng Wang,Jianjian Zhang,and Zhigang Xu.A boron nitride electrode modified with ananocomposite prepared from an ionic liquid and tungsten disulfide for voltammetric sensing of 4-aminophenol,Microchimica Acta,2019,186,614.　　29.Tianyi Cheng,Wenming Huang,Di Gao,Zhe Yang,Congjie Zhang,Haixia Zhang,Jianjian Zhang,Hua Li,and Xiao-Feng Yang*,Michael Addition/S,N-Intramolecular Rearrangement Sequence Enables Selective Fluorescence Detection of Cysteine and Homocysteine.Analytical Chemistry,2019,91,10894?10900.　　28.Ali Hariri,Eric Zhao,Ananthakrishna Soundaram Jeevarathinam,Jeanne Lemaster,Jianjian Zhang&Jesse V.Jokerst,*Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system.Scientific Reports,2019,9,11378.　　27.Haihua Chen,Xueyun Gong,Xiawei Liu,Zheng Li,Jianjian Zhang,Xiao-Feng Yang,*A nitroso-based fluorogenic probe for rapid detection of hydrogen sulfide in living cells.Sensors and Actuators B:Chemical,2019,281,542-548.　　26.Jiangjiang Sun,Qin Wang,Jiajun Yang,Jianjian Zhang,Zheng Li,Hua Li,Xiao-Feng Yang,*2,4-Dinitrobenzenesulfonate-functionalized carbon dots as aturn-on fluorescent probe for imaging of biothiols in living cells.Microchimica Acta,2019,186,402.　　25.Jianjian Zhang,*Penghui Cheng,Kanyi Pu,*Recent Advances of Molecular Optical Probes in Imaging ofβ-Galactosidase.Bioconjugate Chemistry,2019,30,8,2089-2101.(Invited Review)　　24.Yuan Liu,Dandan Rena Jianjian Zhanga,Hua Li,Xiao-Feng Yang*A fluorescent probe for hydrazine based on anewly developed 1-indanonefused coumarin scaffold.Dyes and Pigments 2019,162,112–119.　　23.Biliu Wu,Jiajun Yang,Jianjian Zhang,Zheng Li,Hua Li,Xiao-Feng Yang*A ratiometric fluorescent probe for the detection of endogenous hydroxyl radicals in living cells.Talanta 2019,196,317–324.　　22.Shengrui Zhang,Qin Wang,Xiawei Liu,Jianjian Zhang,Xiao-Feng Yang,*Zheng Li and Hua Li,*Sensitive and Selective Fluorescent Probe for Selenol in Living Cells Designed via apKa Shift Strategy.Anal.Chem.,2018,90,4119-4125.　　21.Jianjian Zhang,Xu Zhen,Jianfeng Zeng,Kanyi Pu,*A Dual-modal Molecular Probe for Near-infrared Fluorescence and Photoacoustic Imaging of Peroxynitrite.Analytical Chemistry,2018,90,9301-9307.　　20.Penghui Cheng,Jianjian Zhang,Jiaguo Huang,Qingqing Miao,Chenjie Xu,Kanyi Pu.*Near-infrared fluorescence probes detect reactive oxygen species for keloid diagnosis.Chemical Science,2018,9,6340-6347.[2018 Chemical Science HOT Article Collection].　　19.Xiaoqian Ma,Xiaoxiao Shi,Shuang Bai,Jianjian Zhang,Meili Hou,Tian Zhang,Bao-sheng Li,Peng Xue,Yuejun Kang and Zhigang Xu.*Water-soluble Fluorescent Unimolecular Micelles:Ultra-small Size,Tunable Fluorescence Emission from Visible to NIR Region and Enhanced Biocompatibility for In Vitro and In Vivo Bioimaging.Chemical Communications,2018,54,6252-6255.　　18.Xu Zhen,Jianjian Zhang,Jiaguo Huang,Chen Xie,Qingqing Miao,Kanyi Pu.*Macrotheranostic probe with disease‐activated near‐infrared fluorescence,photoacoustic and photothermal signals for imaging‐guided therapy.Angewandte Chemie International Edition,2018,57,7804–7808.　　17.Qingqing Miao,David Yeo,Christian Wiraja,Jianjian Zhang,Xiaoyu Ning,Chenjie Xu,Kanyi Pu.*Near-infrared fluorescent molecular probe for sensitive imaging of keloid.Angewandte Chemie International Edition,2018,57,1256–1260.　　入职前发表文章 　　16.Jianjian Zhang,Xu Zhen,Paul Kumar Upputuri,Manojit Pramanik,Peng Chen,Kanyi Pu.*Activatable photoacoustic nanoprobes for in vivo ratiometric imaging of peroxynitrite.Advanced Materials,2017,29,**.[Cover]　　15.Jianxi Wang,Cheng Zhou,Wei Liu,Jianjian Zhang,Xinyue Zhu,Xiaoyan Liu,Qin Wang and Haixia Zhang,*A near-infrared fluorescent probe based on chloroacetate modified naphthofluorescein for selectively detecting cysteine/homocysteine and its application in living cells.Photochemical&Photobiological Sciences,2016,15,1393-1399.　　14.Jianjian Zhang,Chuwen Li,Rui Zhang,Fengyuan Zhang,Wei Liu,Xiaoyan Liu,Simon Ming-Yuen Lee,Haixia Zhang,*A Phosphinate-Based Near-Infrared Fluorescence Probe for Imaging the Superoxide Radical Anion in In Vitro and In Vivo.Chem.Commun.,2016,52,2679-2682.(Front Cover)　　13.Jianjian Zhang,Lulu Ning,Jiting Liu,Jianxi Wang,Bianfei Yu,Xiaoyan Liu,Xiaojun Yao,Zi-Ping Zhang,Haixia Zhang,*Naked-Eye and Near-Infrared Fluorescence Probe for Hydrazine and Its Applications in In Vitro and In Vivo Bioimaging.Anal.Chem.,2015,87,9101-9107.　　12.Jianjian Zhang,Jianxi Wang,Jiting Liu,Lulu Ning,Xinyue Zhu,Bianfei Yu,Xiaoyan Liu,Xiaojun Yao,Haixia Zhang,*Near-Infrared and Naked-Eye Fluorescence Probe for Direct and Highly Selective Detection of Cysteine and Its Application in Living Cells.Anal.Chem.,2015,87,4856-4863.　　11.Jianjian Zhang,Bianfei Yu,Lulu Ning,Xinyue Zhu,Jianxi Wang,Zhenjie Chen,Xiaoyan Liu,Xiaojun Yao,Xiaoyu Zhang,Haixia Zhang,*A Near-Infrared Fluorescence Probe for Thiols Based on Analyte-Specific Cleavage of Carbamate and Its Application in Bioimaging.Eur.J.Org.Chem.,2015,1711-1718.　　10.Jianjian Zhang,Changsong Yan,Yu Peng,*Zhenbiao Luo,Xiaobo Xu,Yawen Wang,Total synthesis of(±)-sacidumlignans Dand Athrough Ueno-Stork radical cyclization reaction.Org.Biomol.Chem.,2013,11,2498-2513.　　9.Xinyue Zhu,Yan Li,Wenyan Zan,Jianjian Zhang,Zhenjie Chen,Xiaoyan Liu,Fengchao Qi,Xiaojun Yao,Xiaoyu Zhang,Haixia Zhang,*A two-photon off-on fluorescence probe for imaging thiols in live cells and tissues.Photochem.Photobiol.Sci.,2016,15,412-419.　　8.Xinyue Zhu,Jianxi Wang,Jianjian Zhang,Zhenjie Chen,Haixia Zhang,*Xiaoyu Zhang,Imaging of Fluoride Ion in Living Cells and Tissues with aTwo-Photon Ratiometric Fluorescence Probe,Sensors,2015,15,1611-1622.　　7.Xinyue Zhu,Hong Gao,Wenyan Zan,Yan Li,Jianjian Zhang,Xiaoyan Liu,Xuan Wei,Fengchao Qi,Xiaojun Yao,Haixia Zhang,*A rational designed thiols fluorescence probe:the positional isomer in PET.Tetrahedron,2016,72,2048-2056.　　6.Yan Li,Yanxin Qiu,Jianjian Zhang,Xinyue Zhu,Bin Zhu,Xiaoyan Liu,Xiaoyu Zhang,Haixia Zhang,*Naphthalimide derived fluorescent probes with turn-on response for Au3+and the application for biological visualization,Biosens.Bioelectron.,2016,83,334-338.　　5.Jianxi Wang，Cheng Zhou，Jianjian Zhang，Xinyue Zhu，Xiaoyan Liu，Qin Wang，Haixia Zhang,*A new fluorescence turn-on probe for biothiols based on photoinduced electron transfer and its application in living cells,Spectrochim Acta A,2016,166,31-37.　　4.Long Luo,Jianjian Zhang,Weijian Ling,Yongliang Shao,Yawen Wang,Yu Peng,*Unified Synthesis of(-)-Folicanthine and(-)-Ditryptophenaline Enabled by aRoom Temperature Nickel-Mediated Reductive Dimerization.Synthesis,2014,46,1908-1916.　　3.Yu Peng,*Zhenbiao Luo,Jianjian Zhang,long Luo,Yawen Wang,Collective synthesis of several 2,7'-cyclolignans and their correlation by chemical transformations.Org.Biomol.Chem.,2013,11,7574-7586.　　2.Yu Peng,*Long Luo,Changsong Yan,Jianjian Zhang,Yawen Wang,Ni-Catalyzed Reductive Homocoupling of Unactivated Alkyl Bromides at Room Temperature and Its Synthetic Application.J.Org.Chem.,2013,78,10960-10967.　　1.Xiaobo Xu,Jian Liu,Jianjian Zhang,Yawen Wang,Yu Peng,*Nickel-Mediated Inter-and Intramolecular C-S Coupling of Thiols and Thioacetates with Aryl Iodides at Room Temperature.Org.Lett.,2013,15,550-553.　　发表会议论文： 　　1.赵景蝉，张健健，张宏芳，分析化学教学实践：从课堂讨论到项目教学，2019新时代高校化学化工教学改革与创新研讨会，2019，中国，厦门
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