姓 名: 刘庆超


性 别: 男



职 称: 副教授/硕士生导师/系主任

学 位: 医学博士


所在院系:西北大学化工学院制药工程系


电子邮件：liuqc21@nwu.edu.cn



通信地址:
西安市太白北路229号西北大学化工学院, 710069


研究方向:天然活性化合物的分离、结构鉴定、合成及构效关系研究；糖类化合物的合成方法学研究


教育与工作经历

2000年09月～2004年07月，中国海洋大学药学专业本科学习，获学士学位；

2005年03月～2005年08月，中国科学院上海有机化学研究所俞彪课题组培训学习；

2005年09月～2010年07月，中国海洋大学医药学院药物化学专业硕博连读，获博士学位；

2010年09月～至今，西北大学化工学院制药工程系任教；

2015年2月-2017年2月，香港理工大学应用生物与化学科技学系，香江****


学术团队、兼职：

中国化学会会员，中国药学会会员，香港****协会会员


荣誉称号：

2014年入选人社部“香江****”；

2015年入选陕西省“青年科技新星”；

2014年入选西北大学”优秀青年学术骨干支持计划”


科研情况

承担主持人社部“香江****”计划项目1项、陕西省青年科技新星项目1项、中国博士后第六批特别资助1项、中国博士后面上项目1项、陕西省科技厅自然基金项目1项、2011年度教育部高等学校博士学科点专项新教师类科研基金1项、陕西省教育厅科学基金1项、西北大学“优秀青年学术骨干”支持计划项目1项、西北大学校内基金1项及西北大学人才引进项目1项， 作为主要参与者参加国家“973”课题项目1项，国家自然科学基金5项、解放军总后勤部项目1项、陕西省自然科学基金1项及陕西省教育厅产业化项目1项。


主要学术论文[1] Han, W. R.; Cai, J.; Zhong, W. M.; Xu, G. M.; Wang, F. Z.; Tian, X. P.; Zhou, X. J.; Liu, Q. C*; Liu, Y. H.; Wang, J. F. Protein tyrosine phosphatase 1B (PTP1B) inhibitors from the deep-sea fungus Penicillium chrysogenum SCSIO 07007. Bioorg. Chem., 96, 10364, 2020.
[2] Guo, T. T.; Song, Y. M.; Lu, Y. H.; Li, G. L.; Liu, T.; Han, W. R.; Song, W. G.; Yang, C. C.; Li, F. H.;Liu, Q. C*. Total synthesis and anticancer activity of the natural oleanolic acid
bidesmoside saponin, albidoside A, isolated from the roots of Acacia
albida. J. Chem. Res., 44(1-2), 42-49, 2020.

[3] Liu, L. L.; Guo, Y. A.; Liu, Q. C*.; Ratnayake, R.; Luesch, H.; Ye, T. Total synthesis of endolides A and B. Synlett, 30(20), 2279-2284, 2019.
[4] Song, Y. M.; Guo, T. T.; Liu, Q. C*.; Li, F. H.; Song, W. G. A sequential one-pot strategy for the synthesis of triterpenoid saponins in ionic liquid [emim][OTf]. J. Chem. Res., 43, 20-25, 2019.

[5] Guo, T. T.; Liu, Q. C*.; Hou, P. B.; Li, F. H.; Guo, S. D.; Song, W. G.; Zhang, H.; Liu, X. Y.; Zhang, S. Y.; Zhang, J. C.; Ho, C. T.; Bai, N. S. Stilbenoids and cannabinoids from the leaves of Cannabis sativa f. sativa with potential reverse cholesterol transport activity. Food Funct., 9, 6609-6618, 2018.

[6] Bai, L.; Liu, Q. C.; Cen, Y. J.; Huang, J. P.; Zhang, X. X.; Guo, S.; Zhang, L.; Guo, T. T.; Ho, C. T.; Bai, N. S. A new sesquiterpene lactone glucoside and other constituents from Inula salsoloids with insecticidal activities on striped flea beetle (Phyllotreta striolata Fabricius). Nat. Prod. Res., 32, 552-557, 2018.

[7] Tian, X.; Guo, S.; He, K.; Roller, M.; Yang, M. Q.; Liu, Q. C.; Zhang, L.; Ho, C. T.; Bai, N. S. Qualitative and quantitative analysis of chemical constituents of Ptychopetalum olacoides Benth. Nat. Prod. Res., 32, 354-357, 2018.

[8] Tian, H.; Liu, Q. C.; Qin, S. C.; Zong, C. L.; Zhang, Y.; Yao, S. T.; Yang, N. N.; Guan, T.;Guo, S. D*. Synthesis and cardiovascular protective effects of quercetin7-O-sialic acid. J. Cell. Mol. Med. 21, 107-120, 2017.


[9] Cui, X. Q.; Guo, J.; Lai, C. S.; Pan, M. H.; Ma, Z. X.; Guo, S.; Liu, Q. C.; Zhang, L.;Ho, C. T.; Bai, N. S. Analysis of bioactive constituents from the leaves of Amorpha fruticosa L. J. Food Drug Anal., 25, 992-999, 2017.

[10] Cui, X. Q.; Ma, Z. X.; Bai, L.; Wu, Y.; Guo, S.; Liu, Q. C.; Zhang, L.; Ho, C. T.; Bai, N. S. Phytochemical analysis of Ziziphus jujuba leaves in six cultivars at the whole life stage by high performance liquid chromatography. Chem. Res. Chin. Univ. 33, 702-708, 2017.
[11] Tian, X.; Yang, M. Q.; Guo, S.; Liu, Q. C.; Zhang, L.; Ho, C. T.; Bai, N. S. Quantitative analysis and chemicalfingerprint similarity for quality control of the seeds of Paeonia suffruticosa Andr. By HPLC. Chem. Res. Chin. Univ. 33, 546-551, 2017.

[12] Liu, Q. C*.; Guo, T. T.; Li, F. H.; Li, D. Concise synthesis of a new triterpenoid saponin from the roots of Gypsophila oldhamiana and its derivatives as α-glucosidase inhibitors. New J. Chem., 40, 9537-9549, 2016.

[13] Liu, Q. C*.; Guo, T. T.; Li, D.; Li, W. H. Concise synthesis and antidiabetic effect of three natural triterpenoid saponins isolated from Fadogia ancylantha (Makoni tea).Res. Chem. Intermed.,42,1611-1626, 2016.

[14] Bai, L.; Guo, S.; Liu, Q. C.; Cui, X. Q.; Zhang, X. X.; Zhang, L.; Yang, X. W.; Hou, M. W.; Ho, C. T.; Bai, N. S*. Characterization of nine polyphenols in fruits of Malus pumila Mill by high-performance liquid chromatography. J. Food Drug Anal. 24, 293-298, 2016.


[15] Bai, L.; Zhang, H.; Liu, Q. C.; Zhao, Y.; Cui, X. Q.; Guo, S.; Zhang, L.; Ho, C. T.; Bai, N. S.*. Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba. Food Funct. 7, 2870-2877, 2016.


[16] Bai, L.; Jiang, M.; Guo, S.; Liu, Q. C.; Zhang, X. X.; Tian, X.; Zhang, L.; Ho, C. T.; Bai, N. S.*. Simultaneous quantification of six sesquiterpene lactones and a flavonoid in the whole life stage of Inula salsoloides by high performance liquid chromatography. Anal. Methods 8, 3587-3591, 2016.


[17] Guo, S.; Cui, X. Q.; Jiang, M.; Bai, L.; Tian, X.; Guo, T. T.; Liu, Q. C.; Zhang, L.; Ho, C. T.; Bai, N. S.*. Simultaneous characterization and quantification of 17 main compounds in Rabdosia rubescens by high performance liquid chromatography. J. Food Drug Anal. DOI:10.1016/j.jfda.2016.05.008, 2016.


[18] Guo, S.; Guo, T. T.; Cheng, N.; Liu, Q. C.; Zhang, Y. T.; Bai, L.; Zhang, L.; Cao, W.; Ho, C. T.; Bai, N. S.*. Hepatoprotective standardized EtOH-water extract from the seeds of Franxinus rhynchophylla Hance.
J. Trad. Comp. Medicine DOI:10.1016/j.jtcme.2016.05.001, 2016.

[19] Feng, Z. L.; Wu, S. P.; Li, W. H.; Guo, T. T.; Liu, Q. C*. Concise synthesis and antidiabetic effect of three natural triterpenoid saponins isolated from Fadogia ancylantha (Makoni tea). Helv. Chim. Acta, 98, 1254-1266, 2015.


[20] Guo, T. T.; Wu, S. P.; Guo, S.; Bai, L.; Liu, Q. C.*; Bai, N. S*. Synthesis of a trisaccharide related to the cytotoxic triterpenoid saponins isolated from the bark of Albizia procera. Arch. Pharm., 348, 615-628,
2015.


[21] Liu, Q. C.; Guo, T. T.; Li, D.; Li, F. H.; Li, W. H*. Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors. Eur. J. Med. Chem. 79, 34-46, 2014.

[22] Liu, Q. C.; Guo, T. T.; Zhang, C.; Sun, J.; Li, W. H*. Synthesis of a trisaccharide related to the cytotoxic triterpenoid saponins isolated from the bark of Albizia procera. Helv. Chim. Acta, 97, 361-368, 2014.


[23] Yang, H. X.; Liu, Q. C.; Zhao, L.; Yuan, Y.; Fan, D. D.; Deng, J. J.; Zhang, R. J*. Fluorescence spectroscopic studies on the interaction of oleanolic acid and its triterpenoid saponins derivatives with two serum albumins. J. Solution Chem. 43, 774-786, 2014.


[24] Liu, Q. C.; Guo, T. T.; Zhang, L.; Yu, Y.; Wang, P.; Yang, J. F.; Li, Y. X*. Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors. Eur. J. Med. Chem., 63, 511-522, 2013.


[25] Liu, Q. C.; Liu, H. C.; Zhang, L.; Guo, T. T.; Wang, P.; Geng, M. Y.; Li, Y. X*. Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives.
Eur. J. Med. Chem., 64, 1-15, 2013.


[26] Liu, Q. C.; Yu, Y.; Wang, P.; Li, Y. X*. Synthesis of analogues of linckoside B, a new neuritogenic steroid glycoside. New J. Chem., 37, 3647-3661, 2013.


[27] Liu, Q. C.; Guo, T. T.; Guo, S. D.; Li, W. H*.; Li, D. Synthesis and evaluation of four hederagenin glycosides as -glucosidase inhibitor. Helv. Chim. Acta, 96 (1),142-149, 2013.


[28] Li, D.; Li, Z.; Li, W. H*.; Liu, Q. C.; Feng, Z. L.; Fan, Z. Hydrotreating of low temperature coal tar to produce clean liquid fuels. J. Anal. Appl. Pyrol. 100, 245-252, 2013.

[29] Liu, Q. C.; Guo, T. T.; Li, W. H*.; Li, D.; Feng, Z. L. Synthesis and evaluation of benzophenone
O-glycosides as ?-glucosidase inhibitors. Arch. Pharm., 345 (10), 771-783, 2012.


[30] Liu, Q. C.; Li, W. H*.; Guo, T. T.; Li, D.; Fan, Z.; Yan, S. H. Efficient synthesis of a bis-glycosyl kaempferol from Fagonia taeckholmiana. Chem. Lett., 3, 324-325, 2011.


[31] Liu, Q. C.; Guo, T. T.; Fan, Z.; Li, D.; Li, W. H. First total synthesis of two new heterocyclic compounds: bretschneiderazines A and B. Chin. Chem. Lett., 22, 801-803, 2011.


[32] Liu, Q. C.; Fan, Z.; Li, D.; Li, W. H*.; Guo, T. T. Facile synthesis of several oleanane-type triterpenoid saponins. J. Carbohydr. Chem., 29, 386-402, 2011.


[33] Guo, T. T.; Liu, Q. C.; Zhang, L.; Wang, P.; Li, Y. X*. Facile synthesis of four natural triterpene saponins with important antitumor activity. Synthetic Commun. 41, 357-371, 2011.

[34] Liu, Q. C.; Wang, P.; Zhang, L.; Guo, T. T.; Lv, G. K.; Li, Y. X*. Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis. Carbohydr. Res. 344, 1276-1281, 2009.


[35] Lv, G. K.; Wang, P.; Liu, Q. C.; Zhang, Z. H.; Zhang, W.; Li, Y. X*. Reactivity-based one-pot synthesis of immunosuppressive glycolipids from the caribbean sponge plakortis simplex.Chin. J. Chem., 27, 2217-2222, 2009.


[36] Guo, T. T.; Liu, Q. C.; Wang, P.; Zhang, L.; Zhang, W.; Li, Y. X*. Facile synthesis of three bidesmosidic oleanolic acid saponins with strong inhibitory activity on pancreatic lipase. Carbohydr. Res. 344 , 1167-1174, 2009.


[37] Luo, Y.; Li, W. H.; Liu, Q. C.; Li, L.; Teng, J. H.; Lei, Y. C. Kinetics of extraction of saponin from
Aralia chinensis L. Huaxue Gongcheng, 39, 81-84, 2011.(in Chinese)


专利


[1] Liu, Q. C.; Liu, L. L.; Liu, T.; Zhu, J. H.; Tong, Y. L. Method for preparation of cyclic heptapeptide rhizonin. Faming Zhuanli Shenqing, CN , 2020.
[2] Liu, Q. C.;
Lu, Y. H.; Song, M. M.; Bai, J. X.; Zhou, X.; Tong, Y. L; Zhu, J. H.; Yun, T. T. Total synthesis of natural product coumarin tyramine glucoside compound. Faming Zhuanli Shenqing, CN , 2020.


[3] Liu, Q. C.; Guo, T. T.; Bai, N. S.; Liu, L. L.; Li, G. L.; Liu, T.; Han, W. R.; Lu, Y. H.; Zhou, X.; Bai, J. X. Jujube flower extract, and its application as antibacterial material. Faming Zhuanli Shenqing, CN ,
2018.
[4] Liu, Q. C. ; Bai, N. S.; Guo, T. T.;
Liu, L. L.; Li, G. L.; Liu, T.; Han, W. R.; Lu, Y. H. Oleanane type nitrogen glycoside compounds useful in treatment of diabetes mellitus and its preparation. Faming Zhuanli Shenqing, CN , 2018.

[5] Liu, Q. C.; Bai, N. S.;
Guo, T. T.;
Liu, L. L.; Li, G. L.; Liu, T.; Han, W. R.; Lu, Y. H. Stilbene compound from hemp leaf and its application in preparing medicine for lowering lipid. Faming Zhuanli Shenqing, CN , 2018.

[6] Bai, N. S.; Guo, S.; Liu, Q. C.; Zhang, Y. T.; Zhang, L.; Bai, L.; Zhang, X. X.; Tian, X. Fraxinus rhynchophylla seed chemical composition standardized extract and its preparation method and application. Faming Zhuanli Shenqing, CN , 2016.


[7] Bai, N. S.; Bai, L.; Wu, Y.; Liu, Q. C.; Zhang, L.; Guo, S.; Cui, X. Q.; Jiang, M. A jujube leaf standardized extract and its preparation and application. CN ,2016.


[8] Bai, N. S.; Liu, Q. C.; Zhang, Y. T.; Xue, W. M.; Bai, L.; Zhang, L.; Guo, T. T.; Wen, H. Y.; Guo, S. Method for extracting secoiridoid glycoside-series compound as hypoglycemic substance from Fraxinus rhynchophylla hance seeds. CN , 2015.

[9] Bai, N. S.; Liu, Q. C.; Bai, L.; Yang, X. W.; Zhang, L.; Guo, T. T.; Hou, M. W.; Guo, J.; Cui, X. Q.
Standardized malic extract, preparation and analysis method. CN , 2015.

[10] Bai, N. S.; Liu, Q. C.; Bai, L.; Zhang, L.; Guo, T. T.; Cui, X. Q.; Wu, Y.; Tian, X.; Jiang, M.; Zhang, X. X.
One kind of standardized jujube extract, its preparation and analysis methods. CN , 2015.


[11] Bai, N. S.; Zhang, J. C.; Liu, Q. C.; Zhang, L.; Bai, L.; Hou, Y. F.; He, J. F.; Zhang, H.; Liu, X. Y.; Zhang, S. Y. New compounds separated from Cannabis sativa leaves and separation method therefore. CN , 2015.


[12] Liu, Q. C. Process for preparation of (α/β)-D-fucose. Faming Zhuanli Shenqing, CN ,
2014.


[13] Li, D.; Li., W. H.; Lei, B. G.; Liu, Q. C.; Li, Z. L. Continuous sulfur supplementing process for hydrogenation of coal tar. CN , 2013.


[14] Li, D.; Li, W. H.; Liu, Q. C.; Li, Z.; Yan, S. H. Method for manufacturing polyphenol extract from infructescence of Platycarya strobilacea. Faming Zhuanli Shenqing, CN , 2011.


[15] Li, Y. X.; Zhang, W.; Ding, N.; Liu, Q. C. Preparation of oleanane-type triterpenoid saponin compounds for treating obesity. Faming Zhuanli Shenqing, CN , 2011.