常惠，博士，副教授，硕士生导师
E-mail：changhui@nwu.edu.cn
研究方向：冬眠生理学与应用生理学、主要侧重于骨骼肌、骨骼与心血管方向
科研工作介绍：目前主要采用生化与分子生物学、细胞生物学、药理学、转录组学、蛋白质组学和代谢组学等方法，通过非冬眠动物疾病模型与冬眠动物的比较生理学研究，寻找冬眠动物非凡的生理适应机制（包括抗废用性肌萎缩、抗废用性骨质疏松及抗心血管缺血-再灌损伤机制），进而为非冬眠动物（包括人类）相关疾病的预防和治疗提供新靶点和新思路。
个人经历
2000-2007年：兰州大学（本硕）
2010-2013年：第四军医大学（博士）
2007-2014年：就职于第四军医大学
2015年至今： 就职于西北大学
讲授课程
生科院全专业三年级《动物生理学》与《动物生理学实验》

指导本科生科研项目及成果
2019，第三届全国大学生生命科学竞赛，二等奖，王思淇、王舒瑶、白飞燕
2019，第一届陕西省大学生生命科学竞赛，特等奖，王思淇、王舒瑶、白飞燕
2019，校创，基于Wnt信号探讨冬眠达乌尔黄鼠与废用大鼠的差异性骨重建机制，王思淇
2019，校创，冬眠期自然废用与夏季活跃期人工废用对达乌尔黄鼠骨重塑影响的比较研究，王舒瑶
2019，国创，健康性肥胖和病理性肥胖对骨代谢影响比较的研究，申沈阳、张钰、张涵
2018，省创，健康性肥胖和病理性肥胖对骨骼肌蛋白代谢的影响，牛巧花、贺楠、方荣蓉
2018，第三届全国大学生生命科学创新创业大赛，三等奖，雷庭筠
2017，校创，人工废用和自然冬眠中快肌与慢肌钙蛋白酶calpain激活机制的比较，雷庭筠
主持项目
2020陕西省自然科学基础研究计划（2020JM-428）
2017 国家自然科学基金应急管理项目（**）
2013 国家自然科学基金青年科学基金项目（**）
2017 陕西省教育厅科学研究计划项目（17JK0792）
2017 西部资源生物与现代生物技术教育部重点实验室开放基金
2016 陕西省自然科学基础研究计划（2016JQ3014）
2015 中国博士后科学基金第58批一等面上资助（2015M580869）
2015 西北大学“优秀青年学术骨干支持计划”
发表论文
1. Chang H, Peng X, Yan X, Zhang J, Xu S, Wang H, Wang Z, Ma X, Gao Y. Autophagy and Akt-mTOR signaling display periodic oscillations during torpor-arousal cycles in oxidative skeletal muscle of Daurian ground squirrels (Spermophilus dauricus). J Comp Physiol B. 2019 Nov 15. doi: 10.1007/s00360-019-01245-5.
2. Chang H, Lei T, Ma X, Zhang J, Wang H, Zhang X, Gao YF. Muscle-specific activation of calpain system in hindlimb unloading rats and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse. J Comp Physiol B. 2018 Sep;188(5):863-876.
3. Chang H, Jiang SF, Ma XF, Peng X, Zhang J, Wang Z, Xu SH, Wang HP, Gao YF. Proteomic analysis reveals the distinct energy and protein metabolism characteristics involved in myofiber type conversion and resistance of atrophy in the extensor digitorum longus muscle of hibernating Daurian ground squirrels. Comp Biochem Physiol Part D Genomics Proteomics. 2018 Feb 13;26:20-31.
4. Chang H, Jiang SF, Dang K, Wang HP, Xu SH, Gao YF. iTRAQ-based proteomic analysis of myofibrillar contents and relevant synthesis and proteolytic proteins in soleus muscle of hibernating Daurian ground squirrels (Spermophilus dauricus). Proteome Sci. 2016 Nov 8;14:16.
5. Chang H, Sheng JJ, Zhang L, Yue ZJ, Jiao B, Li JS, Yu ZB. ROS-induced nuclear translocation of calpain-2 facilitates cardiomyocyte apoptosis in tail-suspended rats. J Cell Biochem. 2015 Oct;116(10):2258-69.
6. Chang H, Ma YG, Wang YY, Song Z, Li Q, Yang N, Zhao HZ, Feng HZ, Chang YM, Ma J, Yu ZB, Xie MJ. High glucose alters transfected HEK293 cell growth by inhibition of cloned BKCa channel. J Cell Physiol. 2011 Jun;226(6):1660-75.
7. Chang H, Zhang L, Xu PT, Li Q, Sheng JJ, Wang YY, Chen Y, Zhang LN, Yu ZB. Nuclear translocation of calpain-2 regulates propensity toward apoptosis in cardiomyocytes of tail-suspended rats. J Cell Biochem. 2011 Feb;112(2):571-80.
8. Ma X¹, Chang H¹, Wang Z, Xu S, Peng X, Zhang J, Yan X, Lei T, Wang H, Gao Y. Differential activation of the calpain system involved in individualized adaptation of different fast-twitch muscles in hibernating Daurian ground squirrels. J Appl Physiol (1985). 2019 Jun 20. doi: 10.1152/japplphysiol.00124.2019.
9. Zhang J, Li Y, Li G, Ma X, Wang H, Goswami N, Hinghofer-Szalkay H, Chang H, Gao Y. Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats. Biomed Pharmacother. 2017 Oct 12;96:513-523. （共同通讯作者）
10. Hu NF¹, Chang H¹, Du B, Zhang QW, Arfat Y, Dang K, Gao YF. Tetramethylpyrazine ameliorated disuse-induced gastrocnemius muscle atrophy in hindlimb unloading rats through suppression of Ca2+/ROS mediated apoptosis. Appl Physiol Nutr Metab. 2017 Feb;42(2):117-127.
11. Sheng JJ¹, Chang H¹, Yu ZB. Nuclear translocation of calpain-2 mediates apoptosis of hypertrophied cardiomyocytes in transverse aortic constriction rat. J Cell Physiol. 2015 Nov;230(11):2743-54.
12. Guo Y¹, Chang H¹, Li J, Xu XY, Shen L, Yu ZB, Liu WC. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway. Apoptosis. 2015 Aug;20(8):1109-21.
13. Bao JX¹, Chang H¹, Lv YG¹, Yu JW, Bai YG, Liu H, Cai Y, Wang L, Ma J, Chang YM.Lysosome-membrane fusion mediated superoxide production in hyperglycaemia-induced endothelial dysfunction. PLoS One. 2012;7(1):e30387.
14. Xie MJ¹, Chang H¹, Wang YY, Zhang L, Song Z, Guo WG, Wang T, Che HL, Yu ZB.Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ. Clin Exp Pharmacol Physiol. 2010 Dec;37(12):1120-8.
15. 常惠，余志斌. 心肌细胞的核质网. 心脏杂志，2013, 25(4):499-502.
16. 常惠，张琳，余志斌. 培养成年大鼠心肌细胞存活的形态标志. 中国应用生理学杂志，2011，27 (1):57-61.
17. 常惠，徐彭涛，李全，圣娟娟，张琳，余志斌. Calpain-2活性升高促进模拟失重大鼠恢复期心肌细胞凋亡. 空军医学杂志，2011, 27 (1):33-36.
18. Zhang J, Wei Y, Qu T, Wang Z, Xu S, Peng X, Yan X, Chang H, Wang H, Gao Y. Prosurvival roles mediated by the PERK signaling pathway effectively prevent excessive endoplasmic reticulum stress-induced skeletal muscle loss during high-stress conditions of hibernation. 2019 Nov; 234(11): 19728-19739. DOI: 10.1002/jcp.28572.
19. Wang Z, Jiang SF, Cao J, Liu K, Xu SH, Arfat Y, Guo QL, Chang H, Goswami N, Hinghofer-Szalkay H, Gao YF. Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen. J Cell Physiol. 2019 Aug; 234(8):13318-13331; doi.org/10.1002/jcp.28008.
20. Wei Y, Zhang J, Xu S, Peng X, Yan X, Li X, Wang H, Chang H, Gao Y. Controllable oxidative stress and tissue specificity in major tissues during the torpor-arousal cycle in hibernating Daurian ground squirrels. Open Biol. 2018 Oct 10;8(10).
21. Wei Y, Gong L, Fu W, Xu S, Wang Z, Zhang J, Ning E, Chang H, Wang H, Gao Y. Unexpected regulation pattern of the IKKβ/NF-κB/MuRF1 pathway with remarkable muscle plasticity in the Daurian ground squirrel (Spermophilus dauricus). J Cell Physiol. 2018 Nov;233(11):8711-8722.
22. Yasir A, Chang H, Gao Y. Stress-responsive microRNAs are involved in re-programming of metabolic functions in hibernators. J Cell Physiol. 2018 Apr;233(4):2695-2704.
23. Guo Q, Mi X, Sun X, Li X, Fu W, Xu S, Wang Q, Arfat Y, Wang H, Chang H, Gao Y. Remarkable plasticity of Na(+), K(+)-ATPase, Ca(2+)-ATPase and SERCA contributes to muscle disuse atrophy resistance in hibernating Daurian ground squirrels. Sci Rep. 2017. 7(1): 10509.
24. Hu H, Du F, Fu W, Jiang S, Cao J, Xu S, Wang H, Chang H, Goswami N, Gao Y. A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus). J Comp Physiol B. 2017 Jul;187(5-6):869-879.
25. Fu W, Hu H, Dang K, Chang H, Du B, Wu X, Gao Y. Remarkable preservation of Ca(2+) homeostasis and inhibition of apoptosis contribute to anti-muscle atrophyeffect in hibernating Daurian ground squirrels. Sci Rep. 2016 Jun 3;6:27020.
26. Yue ZJ, Xu PT, Jiao B, Chang H, Song Z, Xie MJ, and Yu ZB. Nitric oxide protects L-type calcium channel of cardiomyocyte during long-term isoproterenol stimulation in tail-suspended rats. Biomed Res Int. 2015;2015:780814.
27. Sheng JJ, Chen Y, Chang H, Wang YY, Jiao B, Yu ZB. Multisite phosphorylation of Bcl-2 via PKCδ facilitates apoptosis of hypertrophic cardiomyocytes. Clin Exp Pharmacol Physiol. 2014; 41(11):891-901.
28. Zhang L, Song Z, Chang H, Wang YY, Yu ZB. Enhanced N-terminal degradation of troponin I blunts cardiac function responsiveness to isoproterenol in 4-week tail-suspended rats. Mol Med Report. 2013; 7: 271-279.
29. Xu PT, Li Q, Sheng JJ, Chang H, Song Z, Yu ZB. Passive stretch reduces calpain activity through nitric oxide pathway in unloaded soleus muscles. Mol Cell Biochem. 2012;367(1-2):113-24.
30. Fan YZ, Chang H, Yu Y, Liu J, Zhao L, Yang DJ, Wang R. Thymopentin (TP5), an immunomodulatory peptide, suppresses proliferation and induces differentiation in HL-60 cells. Biochim Biophys Acta (BBA) - Molecular Cell Research. 2006;1763(10):1059-66.
31. Fan YZ, Chang H, Yu Y, Liu J, Wang R. Thymosin alpha (1) suppresses proliferation and induces apoptosis in human leukemia cell lines. Peptides. 2006;27(9):2165-73.
32. Liu J, Yu Y, Fan YZ, Chang H, Liu HM, Cui Y, Chen Q, Wang R. Cardiovascular effects of endomorphins in alloxan-induced diabetic rats. Peptides. 2005;26(4):607-14.