个人信息
姓名：王世伟
所属部门：生物技术系
邮 箱：wangsw@nwu.edu.cn
荣誉： 博士生导师，硕士生导师，专业学位硕士生导师
工作经历
2019.4—至今 西北大学 教授
2016.9—2019.3 中科院微生物所 副研究员 中科院青促会会员
2016.2—2016.8 中科院微生物所 助理研究员 导师：马旅雁 研究员
2014.4—2016.2 美国东卡罗莱纳大学 博士后 导师： Yongqing Li 教授
2010.7—2014.3 中科院微生物所 助理研究员
教育背景
2005.9 — 2010.7 中国农业大学 生物学院 微生物与免疫学系 博士 导师：宋渊 教授
2001.9 — 2005.7 黑龙江八一农垦大学 生物学院 生物技术系 本科 导师：秦学功 教授
主要研究方向：环境微生物及其应用
1.微生物在环境修复及石油开采中的应用；
2.铜绿假单胞菌生理学研究；
3.噬菌体分子生物学及其应用


科研基金
1. 汉景帝阳陵博物馆科技考古项目， 汉阳陵陶俑衣物调查研究，2020-2021，在研，主持；
2. 国家自然科学基金面上项目，铜绿假单胞菌胞外多糖Psl和第二信使c-di-GMP交互调控的分子机理，20181-2021，在研，主持；
3. 农业生物技术国家重点实验室开发课题一等资助，阿维链霉菌中铁依赖调控因子 IdeR 的功能研究，2018-2020，在研，主持；
4. 中国科学院青促会会员资助，2018-2019，结题，主持；
5. 国家自然科学基金青年项目，铜绿假单胞菌胞外多糖和鼠李糖脂交互调控的分子机理，2015-2017，结题，主持；
6. 国家留学基金委留学基金，细菌单细胞研究，结题，主持；
7. 国际(地区)合作与交流项目，有机污染物降解微生物组的功能解析和微生物菌群3D打印技术，2019-2022，在研，参加；
8. 国家自然科学基金面上项目，胞外蛋白在铜绿假单胞菌生物被膜中的作用，2013-2016，结题，参加；
9. 国家自然科学基金面上项目，细菌生物被膜形成新因子及相应机制和耐受策略的解析，2016-2019，结题，参加；
10. 国家自然科学基金青年项目, 铜绿假单胞菌氧化应激转录因子OxyR结构与功能的研究, 2014-2016, 结题，参加；
11. 国家自然科学基金青年项目，**，改造产氢酶提高光合深红红螺菌产氢能力的研究，2013-2015，结题，参加；
12. 国家自然科学基金委员会科学部主任基金，铜绿假单胞菌氨肽酶对生物被膜(Biofilm)发育及抗性的贡献，2012-2012，结题，参加。


发表文章 (^#共同第一，* 通讯作者)
1. Yanmei Sun^#, Guang Guo^#, Fang Tian, Huihai Chen, Weijie Liu, Meng Li*, Shiwei Wang* (2020) Antibiotic resistance genes and bacterial community on the surface of five cultivars of fresh tomatoes in China. Ecotoxicology (2020) (Suppl 1) :1-9.
2. Weiyi Liu^#, Fang Wang^#, Yanmei Sun^#, Lei Yang, Huihai Chen, Weijie Liu, Bin Zhu, Chaomao Hui*, Shiwei Wang* (2020) Influence of dragon bamboo with different planting patterns on microbial community and physicochemical property of soil at sunny and shady slopes. Journal of Microbiology. 12275:82-88.
3. Shiwei Wang^#, Qiuqiu Hou^#, Qianqian Guo, Jian Zhang, Yanmei Sun, Hong Wei*, Lixin Shen* (2020) Isolation and characterization of a deoxynivalenol-degrading bacterium Bacillus licheniformis YB9 with the capability of modulating intestinal microbial flora of mice. Toxins. 12(3): 184.
4. Yulu Wang^#, Liyue Wang^#, Jian Zhang, Xintong Duan, Yuqi Feng, Shiwei Wang*, Lixin Shen* (2020) PA0335, a novel gene encoding histidinol phosphate phosphatase mediates histidine auxotrophy in Pseudomonas aeruginosa. Applied and Environmental Microbiology. 86(5):e02593-19.
5. Nana Lu, Yanmei Sun, Qingqin Wang, Yi Qiu, Zhi Chen, Ying Wen, Shiwei Wang*, Yuan Song* (2020) Cloning and characterization of endolysin and holin from Streptomyces avermitilis bacteriophage phiSASD1 as potential novel antibiotic candidates. International Journal of Biological Macromolecules 147:980–989.
6. Guang Guo, Fang Tian, Maomao Tang, Weijie Liu, Cong Liu, Shuwen Xue, Weina Kong, Yanmei Sun*, Shiwei Wang* (2019) Aerobic decolorization and detoxification of Acid Scarlet GR by a newly isolated salt-tolerant yeast strain Galactomyces geotrichum GG. International Biodeterioration & Biodegradation 145:104818.
7. Nana Lu, Choljin Kim, Zhi Chen, Ying Wen, Qing Wei, Yi Qiu, Shiwei Wang*, Yuan Song* (2019) Characterization and genome analysis of a temperate bacteriophage φSAJS1 of Streptomyces avermitilis. Virus Research 265: 34-42.
8. Lin He^#, Shiwei Wang^#, Marta Cortes?o, Muying Wu, Ralf Moeller, Peter Setlow, Yong-qing Li (2018) Single-cell analysis reveals novel insights in the spore resistance to simulated space vacuum. NPJ Microgravity 4:26.
9. Shiwei Wang^#, Haifeng Li^#, Zhijian Li, Yanmei Sun, Jinshui Wang, Meng Li (2018) Fitness of Jiaozi starter for steamed bread production using a two- stage procedure. Food Science and Nutrition 00:1–8.
10. Yanmei Sun^#, Shiwei Wang^#, Junfeng Niu* (2018) Microbial community evolution of black and stinking rivers during in situ remediation through micro-nano bubble and submerged resin floating bed technology. Bioresource Technology 258:187-194.
11. Lin He^#, Zhan Chen^#, Shiwei Wang^#, Muying Wu, Peter Setlow, and Yong-qing Li* (2018) Germination, outgrowth and vegetative growth kinetics of dry heat-treated individual spores of Bacillus species. Applied and Environmental Microbiology 84:e02618-17.
12. Shiwei Wang, Jason Brunt, Michael W. Peck, Peter Setlow and Yong-Qing Li* (2017) Analysis of the Germination of Individual Clostridium sporogenes Spores With and Without Germinant Receptors and Cortex-Lytic Enzymes. Frontiers in Microbiology 8:2047.
13. Shiwei Wang, Barbara Setlow, Peter Setlow, Yong-qing Li* (2016) Uptake and levels of the antibiotic berberine in individual dormant and germinating Clostridium difficile and Bacillus cereus spores as measured by laser tweezers Raman spectroscopy. Journal of Antimicrobial Chemotherapy 71(6):1540-6.
14. Shiwei Wang, Christopher J. Doona, Peter Setlow, Yong-qing Li* (2016) Characterization of cold atmospheric plasma inactivation of individual bacterial spores using Raman spectroscopy and phase contrast microscopy. Applied and Environmental Microbiology 82: 5775-5784. (Selected as spotlight by the Editors)
15. Shiwei Wang, James Faeder, Peter Setlow, Yong-qing Li* (2015) Memory of germinant stimuli in bacterial spores. mBio 6(6): e01859-15. (Editors’ pick and featured in the front page)
16. Shiwei Wang, Jing Yu, Peter Setlow, Yong-qing Li* (2015) Uptake of and resistance to the antibiotic berberine by individual dormant, germinating and outgrowing Bacillus spores as monitored by laser tweezers Raman spectroscopy. PLoS One 10(12): e**.
17. Shiwei Wang, Peter Setlow, Yong-qing Li* (2015) Slow leakage of Ca-dipicolinic acid from individual Bacillus spores during initiation of spore germination. Journal of Bacteriology 197(6):1095-103.
18. Shiwei Wang, Aimee Shen, Peter Setlow, Yong-qing Li*(2015) Characterization of the dynamic germination of individual Clostridium difficile spores using Raman spectroscopy and differential interference contrast microscopy. Journal of Bacteriology 197(14):2361-73.
19. Shiwei Wang, Xi Liu, Hongsheng Liu, Li Zhang, Yuan Guo, Shan Yu, Daniel J. Wozniak, Luyan Z. Ma* (2015) The exopolysaccharide Psl-eDNA interaction enables the formation of a biofilm skeleton in Pseudomonas aeruginosa. Environmental Microbiology Report 7(2):330-340.
20. Shiwei Wang, Shan Yu, Xi Liu, Zhenyin Zhang, Qing Wei, Lu Yan, Guoming Ai, Hongsheng Liu, Luyan Z. Ma* (2014) Coordination of swarming motility, biosurfactant synthesis, and biofilm matrix exopolysaccharide production in Pseudomonas aeruginosa. Applied and Environmental Microbiology 80(21):6724-32. (Selected as spotlight by the Editors, F1000)
21. Shiwei Wang, Matthew R. Parsek, Daniel J. Wozniak, Luyan Z. Ma* (2013) A spider web strategy of type IV pili-mediated migration to build a fiber-like Psl polysaccharide matrix in Pseudomonas aeruginosa biofilms. Environmental Microbiology 15(8): 2238-2253. (Selected as a key scientific article by Global Medical Discovery)
22. Shiwei Wang, Xuewei Qiao, Xiaoxi Liu, Chao Wang, Xuejin Zhao, Zhi Chen, Ying Wen, and Yuan Song* (2010). Complete genomic sequence analysis of the temperate bacteriophage phiSASD1 of Streptomyces avermitilis. Virology 403(1):78-84.
23. Weijie Liu, Ying Chen, Xuge Zhou, Jiwawen Liu, Jingrong Zhu, Shiwei Wang, Cong Liu, Di Sun (2020). The cyclic AMP receptor protein, Crp, is required for the decolorization of acid yellow 36 in Shewanella putrefaciens CN32. Frontiers in Microbiology Doi:10.3389/fmicb.2020.596372.
24. Zhaohui Wang, Yang Li, Bing Hou, Mira I. Pronobis, Mingqiao Wang, Yuemeng Wang, Guangcun Cheng, Weining Weng, Yiqiang Wang, Yanfang Tang, Xuefan Xu, Rong Pan, Fei Lin, Nan Wang, Ziqing Chen, Shiwei Wang, … (2020). An array of 60,000 antibodies for proteome-scale antibody generation and target discovery. Science Advances 6(11): eaax2271.
25. Wei Chen, Lili Huang, Qiusha Tang, Shiwei Wang, Chunmei Hu*, Xia Zhang* (2020). Central Nervous System Tuberculosis: Challenge and Perspective. Radiology of Infectious Disease, Doi:10.1016/j.jrid.2020.07.005.
26. Guang Guo#, Fang Tian#, Liping Zhang, Keqiang Ding, Feng Yang, Zhixin Hu, Chong Liu, Yanmei Sun*, Shiwei Wang (2020). Effect of salinity on removal performance in hydrolysis acidification reactors treating textile wastewater. Bioresource Technology 313:123652.
27. Weijie Liu, Zhen Dong, Di Sun, Qinxin Dong, Shiwei Wang, Jingrong Zhu, Cong Liu* (2020). Production of bioflocculant using feather waste as nitrogen source and its use in recycling of straw ash-washing wastewater with low-density and high pH property. Chemosphere 252:126495.
28. Anming Xu, Di Wang, Yichen Ding, Yaqian Zheng, Bo Wang, Qing Wei, Shiwei Wang, Liang Yang, Luyan Zulie Ma (2020). Integrated comparative genomic analysis and phenotypic profiling of Pseudomonas aeruginosa isolates from crude oil. Frontiers in Microbiology 11:519.
29. Qing Wei, Pramod Bhasme, Zhiguo Wang, Li Wang, Shiwei Wang, Yunfei Zeng, Yi Wang, Yan Li*, Luyan Z Ma* (2020). Chinese medicinal herb extract inhibits PQS-mediated quorum sensing system in Pseudomonas aeruginosa. Journal of Ethnopharmacology 248:112272.
30. Qing Wei, Sebastien Leclercq, Pramod Bhasme, Anming Xu, Bin Zhu, Yuhuan Zhang, Miaokun Zhang, Shiwei Wang, Luyan Ma (2019). Systemic phylogenetic and transcriptomic analyses reveal diguanylate cyclases and phosphodiesterases required for the basal level of c-di-GMP in Pseudomonas aeruginosa. Applied and Environmental Microbiology 85:e01194-19.
31. Weijie Liu^#, Zhen Dong^#, Di Sun, Ying Chen, Shiwei Wang, Jingrong Zhu, Cong Liu* (2019) Bioconversion of kitchen wastes into bio?occulant and its pilot-scale application in treating iron mineral processing wastewater. Bioresource Technology 288:121505.
32. Fang Tian, Guang Guo*, Can Zhang*, Feng Yang, Zhixin Hua, Chong Liu, Shiwei Wang (2019) Isolation, cloning and characterization of an azoreductase and the effect of salinity on its expression in a halophilic bacterium. International Journal of Biological Macromolecules 123: 1062–1069.
33. Guang Guo, Fang Tian, Can Zhang, Tingfeng Liu, Feng Yang, Zhixin Hu, Chong Liu, Shiwei Wang, Keqiang Ding (2019). Performance of a newly enriched bacterial consortium for degrading and detoxifying azo dyes. Water Science and Technology 79(11), 2036-2045.
34. Peter Setlow*, Shiwei Wang, Yong-qing Li (2017) Germination of spores of the orders Bacillales and Clostridiales. Annual Review of Microbiology 71:459-77.
35. Xi Liu, Shiwei Wang, Anming Xu, Li Zhang, Hongsheng Liu, Luyan Z. Ma (2018) Biological Synthesis of High-conductive Protein Nanowires in Aerobic Bacterium Pseudomonas aeruginosa. Applied Microbiology and Biotechnology DOI: https://doi.org/10.1007/s00253-018-9484-5.
36. Weijie Liu, Yanting You, Di Sun, Shiwei Wang, Jingrong Zhu, Cong Liu (2018) Decolorization and detoxification of water-insoluble Sudan dye by Shewanella putrefaciens CN32 co-cutured with Bacillus circulans BWL1061. Ecotoxicology and Environmental Safety 166: 11–17.
37. Yaqing Cheng, Renjun Yang, Xingchao Liu, Mengya Lu, Shiwei Wang, Ying Wen, Yuan Song, Jilun Li, Zhi Chen* (2018) IdeR, a DtxR-family iron-response regulator, controls iron homeostasis, morphological differentiation, secondary metabolism, and oxidative stress response in Streptomyces avermitilis. Applied and Environmental Microbiology 84 (22): e01503-18.
38. Yang Lü, Hua Lu, Shiwei Wang, Jing Han, Hua Xiang, and Cheng Jin* (2017) An acidic exopolysaccharide from Haloarcula hispanica ATCC33960 and two genes responsible for its synthesis. Archaea 10:**.
39. Yi Qiu, Shiwei Wang, Zhi Chen, Yajie Guo, Yuan Song* (2016) An active type I-E CRISPR-Cas system identified in Streptomyces avermitilis. PLoS One 11(2): e**.
40. Luz del Carmen Huesca-Espitia, milomir suvira, Kayla Rosenbeck, George Korza, barbara setlow, William Li, Shiwei Wang, Yong-qing Li, Peter Setlow* (2016) Effects of steam autoclave treatment on Geobacillus stearothermophilus Spores. Journal of Applied Microbiology 121(5):1300-1311.
41. Christopher Doona, Florence Feeherry, Barbara Setlow, Shiwei Wang, William Li, Frank C. Nichols, Prabhat K. Talukda, Mahfuzur R. Sarker, Yong-qing Li, Aimee Shen, Peter Setlow* (2016) Effects of high pressure treatment on spores of Clostridium species. Applied and Environmental Microbiology 82(17): 5287-97.
42. Xuejin Zhao, Qingxin Wang, Weiqun Guo, Yujuan Cai, Chao Wang, Shiwei Wang, Shuangyun Xiang, Yuan Song* (2013) Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains. World Journal Microbiology Biotechnology 10: 1869-1875.
43. Luyan Ma*, Shiwei Wang, Di Wang, Matthew R. Parsek, and Daniel J. Wozniak (2012) The roles of biofilm matrix polysaccharide Psl in mucoid Pseudomonas aeruginosa biofilms. FEMS Immunology and Medicine Microbiology 65(2):377-380. (5-year IF=2.6)
44. Luyan Ma*, Juan Wang, Shiwei Wang, Erin M. Anderson, Joseph S. Lam, Matthew R. Parsek and Daniel J. Wozniak (2012) Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post-transcriptionally regulated. Environmental Microbiology 14(8):1995-2005.
45. Xuejin Zhao, Yuanxin Wang, Shiwei Wang, Zhi Chen, Ying Wen, and Yuan Song* (2009) Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis, Canadian Journal of Microbiology 55: 1355-1363.
46. Juan Du, Shiwei Wang, Ping Yu, Yuan Song*, Chao Wang, and Xuejin Zhao (2008) Combined effects of glycerol and sodium glutamate on color value improvement of a Monascus mutant. China Brewing 23: 56-58.

著作
马旅雁*, 王世伟，张真印，杨霁舟 (2012) 第一章：生物被膜的形成机制， pp1-34。《细菌生物被膜与感染》（周学东，施文元主编）人民医学出版社，北京，中国。
专利
1. 高效抑菌鼠李糖脂高产菌株及其应用。 马旅雁^*，王世伟，王迪，杨新平。公开号：CNA。(已授权)
2. 一株适用于油藏环境的假单胞菌及其应用。马旅雁^*，王世伟， 王迪，杨新平。公开号: CNA。(已授权)
3. 提高鼠李糖脂产量的方法及其专用铜绿假单胞菌。马旅雁^*，王世伟。公开号： CNA。(已授权)
4. 韩国芽孢八叠球菌CGMCC No. 5915 应用及脂肽类表面活性素制备方法和组合物。王世伟，李萌，孙艳梅，刘伟杰，陈慧海，黎永青。专利号: 2017.**.1 。(已授权)
5. 用于抑制/瓦解生物被膜的抑制剂及其应用。马旅雁*、王世伟、于珊、吴慧君、王迪。国际专利号：PCT/CN2016/076171，PUS15/557,812。 (国际专利-已授权)
6. 一种构建高产鼠李糖脂菌株的方法。马旅雁*、王世伟。申请号：5.8。（受理）
7. 一种促进固氮细菌形成胞囊结构的方法及其专用培养基。 马旅雁*、王迪、王世伟、徐安明。专利号：1.2。（受理）
8. 导电四型菌毛及其编码基因和含有该基因的载体和相应的生产菌株及其应用。 马旅雁，刘茜，王世伟。专利号：4.6。（受理）