常惠，博士，副教授，硕士生导师。
邮箱：changhui@nwu.edu.cn

主要研究方向 冬眠生理学与应用生理学，侧重于骨骼肌、骨骼与心血管方向。
目前主要采用生化与分子生物学、细胞生物学、药理学、转录组学、蛋白质组学和代谢组学等方法，研究冬眠动物达乌尔黄鼠非凡的“抗废用性骨骼肌萎缩”、“抗废用性骨质疏松”以及“心肌细胞和血管平滑肌细胞的抗缺血-再灌损伤”机制。同时通过非冬眠动物疾病模型与冬眠动物的比较生理学研究，为非冬眠动物（包括人类）相关疾病的预防和治疗寻找新靶点和新思路。

个人经历 2000-2007年：兰州大学（本硕）导师：王锐 院士 陈强 教授
2010-2013年：第四军医大学（博士） 导师：余志斌 教授
2007-2014年：就职于第四军医大学
2015年至今： 就职于西北大学

讲授课程 生科院全专业大学三年级《动物生理学》与《动物生理学实验》



社会兼职 中国生理学会比较生理学专业委员会委员
陕西省动物学会理事
陕西省生理学会理事

获得荣誉 中国动物学会动物生理生态学分会授予 “优秀青年动物生理生态学工作者”称号
西北大学“优秀青年学术骨干支持计划”
第四军医大学“精英人才计划”

指导本科生科研项目及成果 2020年 第二届陕西省大学生生命科学竞赛暨第四届全国大学生生命科学竞赛，三等奖，牛巧花，申沈阳
2020年 校创，冬眠达乌尔黄鼠快肌与慢肌的转录组学研究，吴泽华，秦嘉豪
2020年 校创，冬眠达乌尔黄鼠快肌与慢肌自噬水平的变化与调控研究机制，高展，张冉
2019年 第三届全国大学生生命科学竞赛，二等奖，王思淇、王舒瑶、白飞燕
2019年 第一届陕西省大学生生命科学竞赛，特等奖，王思淇、王舒瑶、白飞燕
2019年 校创，基于Wnt信号探讨冬眠达乌尔黄鼠与废用大鼠的差异性骨重建机制，王思淇
2019年 校创，冬眠期自然废用与夏季活跃期人工废用对达乌尔黄鼠骨重塑影响的比较研究，王舒瑶
2019年 国创，健康性肥胖和病理性肥胖对骨代谢影响比较的研究，申沈阳、张钰、张涵
2018年 省创，健康性肥胖和病理性肥胖对骨骼肌蛋白代谢的影响，牛巧花、贺楠、方荣蓉
2018年 第三届全国大学生生命科学创新创业大赛，三等奖，雷庭筠
2017年 校创，人工废用和自然冬眠中快肌与慢肌钙蛋白酶calpain激活机制的比较，雷庭筠

主持项目 2020年 陕西省自然科学基础研究计划（2020JM-428）
2017年 国家自然科学基金 应急管理项目（**）
2013年 国家自然科学基金 青年科学基金项目（**）
2017年 陕西省教育厅科学研究计划项目（17JK0792）
2017年 西部资源生物与现代生物技术教育部重点实验室开放基金
2016年 陕西省自然科学基础研究计划（2016JQ3014）
2015年 中国博士后科学基金第58批一等面上资助（2015M580869）
2015年 西北大学“优秀青年学术骨干支持计划”
2010年 第四军医大学精英人才计划“优秀文职人员培养基金”

发表文章 1. Yan X, Gao X, Niu Q, Peng X, Zhang J, Ma X, Wei Y, Wang H, Gao Y, Chang H. Differential protein metabolism and regeneration in hypertrophic diaphragm and atrophic gastrocnemius muscles in hibernating Daurian ground squirrels. Experimental Physiology. Exp Physiol. 2021 Jan 31. doi: 10.1113/EP089187.
2. Yan X, Niu Q, Gao X, Shen S, He N, Wang H, Fang R, Gao Y, Chang H. Differential protein metabolism and regeneration in gastrocnemius muscles in high-fat diet fed mice and pre-hibernation Daurian ground squirrels: a comparison between pathological and healthy obesity. Zool Stud 2021 60:6. doi:10.6620/ZS.2021.60-06.
3. Chang H, Peng X, Yan X, Zhang J, Xu S, Wang H, Wang Z, Ma X, Gao Y. Autophagy and Akt-mTOR signaling display periodic oscillations during torpor-arousal cycles in oxidative skeletal muscle of Daurian ground squirrels (Spermophilus dauricus). J Comp Physiol B. 2020 Jan;190(1):113-123.
4. Chang H, Lei T, Ma X, Zhang J, Wang H, Zhang X, Gao YF. Muscle-specific activation of calpain system in hindlimb unloading rats and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse. J Comp Physiol B. 2018 Sep;188(5):863-876.
5. Chang H, Jiang SF, Ma XF, Peng X, Zhang J, Wang Z, Xu SH, Wang HP, Gao YF. Proteomic analysis reveals the distinct energy and protein metabolism characteristics involved in myofiber type conversion and resistance of atrophy in the extensor digitorum longus muscle of hibernating Daurian ground squirrels. Comp Biochem Physiol Part D Genomics Proteomics. 2018 Feb 13;26:20-31.
6. Chang H, Jiang SF, Dang K, Wang HP, Xu SH, Gao YF. iTRAQ-based proteomic analysis of myofibrillar contents and relevant synthesis and proteolytic proteins in soleus muscle of hibernating Daurian ground squirrels (Spermophilus dauricus). Proteome Sci. 2016 Nov 8;14:16.
7. Chang H, Sheng JJ, Zhang L, Yue ZJ, Jiao B, Li JS, Yu ZB. ROS-induced nuclear translocation of calpain-2 facilitates cardiomyocyte apoptosis in tail-suspended rats. J Cell Biochem. 2015 Oct;116(10):2258-69.
8. Chang H, Ma YG, Wang YY, Song Z, Li Q, Yang N, Zhao HZ, Feng HZ, Chang YM, Ma J, Yu ZB, Xie MJ. High glucose alters transfected HEK293 cell growth by inhibition of cloned BKCa channel. J Cell Physiol. 2011 Jun;226(6):1660-75.
9. Chang H, Zhang L, Xu PT, Li Q, Sheng JJ, Wang YY, Chen Y, Zhang LN, Yu ZB. Nuclear translocation of calpain-2 regulates propensity toward apoptosis in cardiomyocytes of tail-suspended rats. J Cell Biochem. 2011 Feb;112(2):571-80.
10. Zhang J, Chang H¹, Yin R, Xu S, Wang H, Gao Y. A temporal study on musculoskeletal morphology and metabolism in hibernating Daurian ground squirrels (Spermophilus dauricus). Bone. 2020 Dec 18:115826. doi: 10.1016/j.bone.2020.115826.
11. Zhang J, Li X, Ismail F, Xu S, Wang Z, Peng X, Yang C, Chang H, Wang H, Gao Y. Priority Strategy of Intracellular Ca²⁺ Homeostasis in Skeletal Muscle Fibers During the Multiple Stresses of Hibernation. Cells. 2019 Dec 22;9(1). pii: E42.（共同通讯作者）
12. Ma X¹, Chang H¹, Wang Z, Xu S, Peng X, Zhang J, Yan X, Lei T, Wang H, Gao Y. Differential activation of the calpain system involved in individualized adaptation of different fast-twitch muscles in hibernating Daurian ground squirrels. J Appl Physiol (1985). 2019 Jun 20. doi: 10.1152/japplphysiol.00124.2019.
13. Zhang J, Li Y, Li G, Ma X, Wang H, Goswami N, Hinghofer-Szalkay H, Chang H, Gao Y. Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats. Biomed Pharmacother. 2017 Oct 12;96:513-523. （共同通讯作者）
14. Hu NF¹, Chang H¹, Du B, Zhang QW, Arfat Y, Dang K, Gao YF. Tetramethylpyrazine ameliorated disuse-induced gastrocnemius muscle atrophy in hindlimb unloading rats through suppression of Ca2+/ROS mediated apoptosis. Appl Physiol Nutr Metab. 2017 Feb;42(2):117-127.
15. Sheng JJ¹, Chang H¹, Yu ZB. Nuclear translocation of calpain-2 mediates apoptosis of hypertrophied cardiomyocytes in transverse aortic constriction rat. J Cell Physiol. 2015 Nov;230(11):2743-54.
16. Guo Y¹, Chang H¹, Li J, Xu XY, Shen L, Yu ZB, Liu WC. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway. Apoptosis. 2015 Aug;20(8):1109-21.
17. Bao JX¹, Chang H¹, Lv YG¹, Yu JW, Bai YG, Liu H, Cai Y, Wang L, Ma J, Chang YM.Lysosome-membrane fusion mediated superoxide production in hyperglycaemia-induced endothelial dysfunction. PLoS One. 2012;7(1):e30387.
18. Xie MJ¹, Chang H¹, Wang YY, Zhang L, Song Z, Guo WG, Wang T, Che HL, Yu ZB.Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ. Clin Exp Pharmacol Physiol. 2010 Dec;37(12):1120-8.
19. 常惠，余志斌. 心肌细胞的核质网. 心脏杂志，2013, 25(4):499-502.
20. 常惠，张琳，余志斌. 培养成年大鼠心肌细胞存活的形态标志. 中国应用生理学杂志，2011，27 (1):57-61.
21. 常惠，徐彭涛，李全，圣娟娟，张琳，余志斌. Calpain-2活性升高促进模拟失重大鼠恢复期心肌细胞凋亡. 空军医学杂志，2011, 27 (1):33-36.
22. Zhang J, Wei Y, Qu T, Wang Z, Xu S, Peng X, Yan X, Chang H, Wang H, Gao Y. Prosurvival roles mediated by the PERK signaling pathway effectively prevent excessive endoplasmic reticulum stress-induced skeletal muscle loss during high-stress conditions of hibernation. J Cell Physiol. 2019 Nov; 234(11): 19728-19739. DOI: 10.1002/jcp.28572.
23. Wang Z, Jiang SF, Cao J, Liu K, Xu SH, Arfat Y, Guo QL, Chang H, Goswami N, Hinghofer-Szalkay H, Gao YF. Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen. J Cell Physiol. 2019 Aug; 234(8):13318-13331; doi.org/10.1002/jcp.28008.
24. Wei Y, Zhang J, Xu S, Peng X, Yan X, Li X, Wang H, Chang H, Gao Y. Controllable oxidative stress and tissue specificity in major tissues during the torpor-arousal cycle in hibernating Daurian ground squirrels. Open Biol. 2018 Oct 10;8(10).
25. Wei Y, Gong L, Fu W, Xu S, Wang Z, Zhang J, Ning E, Chang H, Wang H, Gao Y. Unexpected regulation pattern of the IKKβ/NF-κB/MuRF1 pathway with remarkable muscle plasticity in the Daurian ground squirrel (Spermophilus dauricus). J Cell Physiol. 2018 Nov;233(11):8711-8722.
26. Yasir A, Chang H, Gao Y. Stress-responsive microRNAs are involved in re-programming of metabolic functions in hibernators. J Cell Physiol. 2018 Apr;233(4):2695-2704.
27. Guo Q, Mi X, Sun X, Li X, Fu W, Xu S, Wang Q, Arfat Y, Wang H, Chang H, Gao Y. Remarkable plasticity of Na(+), K(+)-ATPase, Ca(2+)-ATPase and SERCA contributes to muscle disuse atrophy resistance in hibernating Daurian ground squirrels. Sci Rep. 2017. 7(1): 10509.
28. Hu H, Du F, Fu W, Jiang S, Cao J, Xu S, Wang H, Chang H, Goswami N, Gao Y. A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus). J Comp Physiol B. 2017 Jul;187(5-6):869-879.
29. Fu W, Hu H, Dang K, Chang H, Du B, Wu X, Gao Y. Remarkable preservation of Ca(2+) homeostasis and inhibition of apoptosis contribute to anti-muscle atrophyeffect in hibernating Daurian ground squirrels. Sci Rep. 2016 Jun 3;6:27020.
30. Yue ZJ, Xu PT, Jiao B, Chang H, Song Z, Xie MJ, and Yu ZB. Nitric oxide protects L-type calcium channel of cardiomyocyte during long-term isoproterenol stimulation in tail-suspended rats. Biomed Res Int. 2015;2015:780814.
31. Sheng JJ, Chen Y, Chang H, Wang YY, Jiao B, Yu ZB. Multisite phosphorylation of Bcl-2 via PKCδ facilitates apoptosis of hypertrophic cardiomyocytes. Clin Exp Pharmacol Physiol. 2014; 41(11):891-901.
32. Zhang L, Song Z, Chang H, Wang YY, Yu ZB. Enhanced N-terminal degradation of troponin I blunts cardiac function responsiveness to isoproterenol in 4-week tail-suspended rats. Mol Med Report. 2013; 7: 271-279.
33. Xu PT, Li Q, Sheng JJ, Chang H, Song Z, Yu ZB. Passive stretch reduces calpain activity through nitric oxide pathway in unloaded soleus muscles. Mol Cell Biochem. 2012;367(1-2):113-24.
34. Fan YZ, Chang H, Yu Y, Liu J, Zhao L, Yang DJ, Wang R. Thymopentin (TP5), an immunomodulatory peptide, suppresses proliferation and induces differentiation in HL-60 cells. Biochim Biophys Acta (BBA) - Molecular Cell Research. 2006;1763(10):1059-66.
35. Fan YZ, Chang H, Yu Y, Liu J, Wang R. Thymosin alpha (1) suppresses proliferation and induces apoptosis in human leukemia cell lines. Peptides. 2006;27(9):2165-73.
36. Liu J, Yu Y, Fan YZ, Chang H, Liu HM, Cui Y, Chen Q, Wang R. Cardiovascular effects of endomorphins in alloxan-induced diabetic rats. Peptides. 2005;26(4):607-14.




获得的教学和科研表彰

2015年 西北大学“优秀青年学术骨干支持计划”
2010年 第四军医大学“精英人才计划”

常惠

所属部门： 教师
职称： 副教授
荣誉： 硕士生导师
研究方向： 冬眠生理学与应用生理学主要侧重于骨骼肌、骨骼与心血管方向

电子邮件： changhui@nwu.edu.cn