He, Na1; Wang, Yude2; Huang, Yan2,3; Chen, Lingxin3
; Wang, Xiaoyan2,3; Lv, Changjun2; Yue, Shouwei1发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
2020-11-21
卷号8期号:43页码:9899-9905
DOI10.1039/d0tb01969k
通讯作者Chen, Lingxin(lxchen@yic.ac.cn); Lv, Changjun(lucky_lcj@sina.com); Yue, Shouwei(shouweiy@sdu.edu.cn)
英文摘要Acute lung injury (ALI) is a diffuse inflammatory pulmonary damage caused by excessive ROS that break the coordination of normal physiological structures and functions. Hypochlorous acid (HOCl), one kind of ROS, is a hopeful biological marker for inflammation-related diseases. Therefore, the excessive generation of HOCl might be a significant reason for oxidative injury in ALI. Herein, we developed a fluorescent probe, namely BCy-HOCl, for quantitatively monitoring and visualizing HOCl in living cells and in vivo. The probe BCy-HOCl displayed a significant fluorescence signal enhancement towards HOCl with excellent selectivity and sensitivity. The variation of HOCl in the ALI cell model and ALI mouse model was evaluated with BCy-HOCl to clarify the relationship between ALI and HOCl. Our results verified that the HOCl levels conspicuously increased with the severity of the ALI. Thus, HOCl is likely to play a crucial part in the process of ALI, which will probably provide a new strategy for its treatment.
资助机构National Nature Science Foundation of China; Science and Technology Innovation Development Plan of Yantai of China; Research Initiation Fund of Binzhou Medical University; Taishan Scholar Project Special Funding
收录类别SCI
语种英语
关键词[WOS]RESPIRATORY-DISTRESS-SYNDROME; IMAGING BASAL; LIVE-CELL; MITOCHONDRIA; HCLO; LYSOSOME
研究领域[WOS]Materials Science
WOS记录号WOS:000588549200006
引用统计被引频次：6[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/28336
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
中科院海岸带环境过程与生态修复重点实验室
通讯作者Chen, Lingxin; Lv, Changjun; Yue, Shouwei作者单位1.Shandong Univ, Qilu Hosp, Cheelo Coll Med, Rehabil Ctr, Jinan 250100, Peoples R China
2.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714He, Na,Wang, Yude,Huang, Yan,et al. Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(43):9899-9905.
APAHe, Na.,Wang, Yude.,Huang, Yan.,Chen, Lingxin.,Wang, Xiaoyan.,...&Yue, Shouwei.(2020).Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models.JOURNAL OF MATERIALS CHEMISTRY B,8(43),9899-9905.
MLAHe, Na,et al."Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models".JOURNAL OF MATERIALS CHEMISTRY B 8.43(2020):9899-9905.
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