Zhang, Hongxia1,2,3,4; Wang, Qing3,5
; Zhao, Jianmin3,5; Liu, Shilin1,2,3,4; Zhang, Libin1,2,3,4,8; Zhao, Ye6; Yang, Hongsheng1,2,3,4,7; Sun, Lina1,2,3,4发表期刊GENOMICS
ISSN0888-7543
2020-11-01
卷号112期号:6页码:5012-5020
关键词Apostichopus japonicusIntestine regenerationIntestinal microbiotaQuantitative microbiomeRegeneration rate
DOI10.1016/j.ygeno.2020.09.017
通讯作者Sun, Lina(sunlina@qdio.ac.cn)
英文摘要The intestinal microbiota may play important roles in regenerating intestine of the sea cucumber Apostichopus japonicus, the underlying mechanism remains unclear. In the present study, a germ-free sea cucumber model was developed, and the intestinal microbial differentiation of faster and slower regenerating A. japonicus individuals during intestine regeneration was analyzed. The results revealed that depletion of the intestinal microbiota resulted in elevated abundance of the potential key players Flavobacteriaceae and Rhodobacteraceae during intestine regeneration and thus promoted the intestine regeneration rate of A. japonicus. Metagenomic analysis revealed that the increased abundance of Flavobacteriaceae elevated the enrichment of genes associated with carbohydrate utilization, whereas the abundant Rhodobacteraceae-enriched genes were associated with polyhydroxybutyrate production. We identified microbiota abundance as a key driver of microbial community alterations, especially beneficial microbiota members, in the developing intestine of A. japonicus. This study provides new insights into the mechanism of host-microbiota interactions related to organ regeneration.
资助机构National Natural Science Foundation of China; China Postdoctoral Science Foundation; Youth Talent Support Program of the Laboratory for Marine Ecology and Environmental Science; Pilot National Laboratory for Marine Science and Technology (Qingdao); Taishan Scholars Program (Distinguished Taishan Scholars), TwoHundred Talents Plan of Yantai; Youth Innovation Promotion Association CAS; Chinese Academy of Sciences
收录类别SCI
语种英语
关键词[WOS]BACTERIAL DIVERSITY; GUT; EXPRESSION; GROWTH; FLAVOBACTERIACEAE; IDENTIFICATION; ALIGNMENT; PROTEIN; GENES
研究领域[WOS]Biotechnology & Applied Microbiology; Genetics & Heredity
WOS记录号WOS:000600731500010
引用统计被引频次：4[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/27544
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者Sun, Lina作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China
5.Chinese Acad Sci, CAS Res & Dev Ctr Efficient Utilizat Coastal Bior, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
6.Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China
7.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
8.Minist Nat Resources, Inst Oceanog 2, State Key Lab Satellite Ocean Environm Dynam, Hangzhou 310012, Peoples R China
推荐引用方式
GB/T 7714Zhang, Hongxia,Wang, Qing,Zhao, Jianmin,et al. Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus[J]. GENOMICS,2020,112(6):5012-5020.
APAZhang, Hongxia.,Wang, Qing.,Zhao, Jianmin.,Liu, Shilin.,Zhang, Libin.,...&Sun, Lina.(2020).Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus.GENOMICS,112(6),5012-5020.
MLAZhang, Hongxia,et al."Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus".GENOMICS 112.6(2020):5012-5020.
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