Zhong, Mingyu1; Wu, Huifeng1,2,3
; Li, Fei1,3; Shan, Xiujuan2; Ji, Chenglong1,2,3发表期刊ENVIRONMENTAL POLLUTION
ISSN0269-7491
2020-12-01
卷号267页码:11
关键词Trichloropropyl phosphate (TCPP)Mytilus galloprovincialisGender-specific effectsiTRAQProteomics
DOI10.1016/j.envpol.2020.115537
通讯作者Wu, Huifeng(hfwu@yic.ac.cn)
英文摘要Trichloropropyl phosphate (TCPP) is a halogenated organophosphate ester that is widely used as flame retardants and plasticizers. In this study, gender-specific accumulation and responses in mussel Mytilus galloprovincialis to TCPP exposure were focused and highlighted. After TCPP (100 nmol L-1) exposure for 42 days, male mussels showed similar average bioaccumulation (37.14 6.09 nmol g(-1) fat weight (fw)) of TCPP with that in female mussels (32.28 +/- 4.49 nmol g(-1) fw). Proteomic analysis identified 219 differentially expressed proteins (DEPs) between male and female mussels in control group. There were 52 and 54 DEPs induced by TCPP in male and female mussels, respectively. Interestingly, gender-specific DEPs included 37 and 41 DEPs induced by TCPP in male and female mussels, respectively. The proteomic differences between male and female mussels were related to protein synthesis and degradation, energy metabolism, and functions of cytoskeleton and motor proteins. TCPP influenced protein synthesis, energy metabolism, cytoskeleton functions, immunity, and reproduction in both male and female mussels. Protein-protein interaction (PPI) networks indicated that protein synthesis and energy metabolism were the main biological processes influenced by TCPP. However, DEPs involved in these processes and their interaction patterns were quite different between male and female mussels. Basically, twelve ribosome DEPs which directly or indirectly interacted were found in protein synthesis in TCPPexposed male mussels, while only 3 ribosome DEPs (not interacted) in TCPP-exposed female mussels. In energy metabolism, only 4 DEPs (with the relatively simple interaction pattern) mainly resided in fatty acid metabolism, butanoate/propanoate metabolism and glucose metabolism were discovered in TCPPexposed male mussels, and more DEPs (with multiple interactions) functioned in TCA cycle and pyruvate/glyoxylate/dicarboxylate metabolism were found in TCCP-exposed female mussels. Taken together, TCPP induced gender-specific toxicological effects in mussels, which may shed new lights on further understanding the toxicological mechanisms of TCPP in aquatic organisms. (c) 2020 Elsevier Ltd. All rights reserved.
资助机构National Natural Science Foundation of China; Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao); Youth Innovation Promotion Association CAS
收录类别SCI
语种英语
关键词[WOS]ORGANOPHOSPHATE FLAME RETARDANTS; PHYSICAL-CHEMICAL PROPERTIES; MESSENGER-RNA EXPRESSION; SPATIAL-DISTRIBUTION; YELLOW SEAS; BOHAI SEA; PLASTICIZERS; PROTEIN; CHROMATOGRAPHY; TOXICITY
研究领域[WOS]Environmental Sciences & Ecology
WOS记录号WOS:000593966400007
引用统计被引频次：4[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/27529
专题中科院海岸带环境过程与生态修复重点实验室
中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者Wu, Huifeng作者单位1.Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714Zhong, Mingyu,Wu, Huifeng,Li, Fei,et al. Proteomic analysis revealed gender-specific responses of mussels (Mytilus galloprovincialis) to trichloropropyl phosphate (TCPP) exposure[J]. ENVIRONMENTAL POLLUTION,2020,267:11.
APAZhong, Mingyu,Wu, Huifeng,Li, Fei,Shan, Xiujuan,&Ji, Chenglong.(2020).Proteomic analysis revealed gender-specific responses of mussels (Mytilus galloprovincialis) to trichloropropyl phosphate (TCPP) exposure.ENVIRONMENTAL POLLUTION,267,11.
MLAZhong, Mingyu,et al."Proteomic analysis revealed gender-specific responses of mussels (Mytilus galloprovincialis) to trichloropropyl phosphate (TCPP) exposure".ENVIRONMENTAL POLLUTION 267(2020):11.
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