Liu, Ya-Ping1,2; Fang, Sheng-Tao1
; Shi, Zhen-Zhen1; Wang, Bin-Gui3; Li, Xiao-Nian4; Ji, Nai-Yun1发表期刊MARINE DRUGS
2021
卷号19期号:1页码:10
关键词Penicillium oxalicumdeep seacold seepphenylhydrazonequinazoline
DOI10.3390/md19010009
通讯作者Ji, Nai-Yun(nyji@yic.ac.cn)
英文摘要Three new phenylhydrazones, penoxahydrazones A-C (compounds 1-3), and two new quinazolines, penoxazolones A (compound 4) and B (compound 5), with unique linkages were isolated from the fungus Penicillium oxalicum obtained from the deep sea cold seep. Their structures and relative configurations were assigned by analysis of 1D/2D NMR and mass spectroscopic data, and the absolute configurations of 1, 4, and 5 were established on the basis of X-ray crystallography or ECD calculations. Compound 1 represents the first natural phenylhydrazone-bearing steroid, while compounds 2 and 3 are rarely occurring phenylhydrazone tautomers. Compounds 4 and 5 are enantiomers that feature quinazoline and cinnamic acid units. Some isolates exhibited inhibition of several marine phytoplankton species and marine-derived bacteria.
资助机构National Key R&D Program of China; Taishan Scholar Project; Shuangbai Plan of Yantai; Youth Innovation Promotion Association of CAS; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences
收录类别SCI
语种英语
研究领域[WOS]Pharmacology & Pharmacy
WOS记录号WOS:000611035300001
引用统计被引频次：3[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/27475
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者Ji, Nai-Yun作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Ctr Ocean Mega Sci, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Ctr Ocean Mega Sci, Inst Oceanol,Key Lab Expt Marine Biol,Lab Marine, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
推荐引用方式
GB/T 7714Liu, Ya-Ping,Fang, Sheng-Tao,Shi, Zhen-Zhen,et al. Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum[J]. MARINE DRUGS,2021,19(1):10.
APALiu, Ya-Ping,Fang, Sheng-Tao,Shi, Zhen-Zhen,Wang, Bin-Gui,Li, Xiao-Nian,&Ji, Nai-Yun.(2021).Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum.MARINE DRUGS,19(1),10.
MLALiu, Ya-Ping,et al."Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum".MARINE DRUGS 19.1(2021):10.
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