He, Na1; Yu, Lei2; Xu, Minghua3; Huang, Yan4,5; Wang, Xiaoyan4,5; Chen, Lingxin4,5,6
; Yue, Shouwei1发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
2021-03-21
卷号9期号:11页码:2623-2630
DOI10.1039/d0tb02833a
通讯作者Chen, Lingxin(lxchen@yic.ac.cn); Yue, Shouwei(shouweiy@sdu.edu.cn)
英文摘要Dietary restriction (DR), as a natural intervention, not only benefits the neuroendocrine system, but also has an antiaging action. Acetylcholinesterase (AChE) is one of the most important bioactive substances and plays a major part in choline changes in the aging process. Thus, we aim to evaluate the effect of DR on AChE in the brains of aging animals. In this study, we synthesize a NIR fluorescent probe BD-AChE for the real-time and in situ monitoring of AChE level changes in living cells and living mice, notably in brains. In situ visualization with BD-AChE verified a decrease in the AchE level in the brains of mice aging models. Evidently, the prepared probe has the excellent capability of measuring AChE variation in the brains of aging mice with DR via NIR fluorescence bioimaging, indicating that long-term DR can effectively affect AChE levels in the brain. The attenuation of AChE level in the brain of aging mice after DR could be helpful in infering the advantageous impact of DR on age-related neurodegenerative disease, as a better treatment alternative in the future.
资助机构National Nature Science Foundation of China; Science and Technology Innovation Development Plan of Yantai of China; Research Initiation Fund of Binzhou Medical University; Taishan Scholar Project Special Funding; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization; Weifang Science and Technology Development Project
收录类别SCI
语种英语
研究领域[WOS]Materials Science
WOS记录号WOS:000632213400003
引用统计被引频次：2[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/27245
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
中科院海岸带环境过程与生态修复重点实验室
通讯作者Chen, Lingxin; Yue, Shouwei作者单位1.Shandong Univ, Qilu Hosp, Cheelo Coll Med, Rehabil Ctr, Jinan 250100, Peoples R China
2.Weifang Univ Sci & Technol, Shandong Peninsula Engn Res Ctr Comprehens Brine, Weifang 262700, Peoples R China
3.Yantai Cent Blood Stn, Yantai 264003, Peoples R China
4.Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
6.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714He, Na,Yu, Lei,Xu, Minghua,et al. Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021,9(11):2623-2630.
APAHe, Na.,Yu, Lei.,Xu, Minghua.,Huang, Yan.,Wang, Xiaoyan.,...&Yue, Shouwei.(2021).Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging.JOURNAL OF MATERIALS CHEMISTRY B,9(11),2623-2630.
MLAHe, Na,et al."Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging".JOURNAL OF MATERIALS CHEMISTRY B 9.11(2021):2623-2630.
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