Wang, Yue1,2; Chen, Lingxin1,3
发表期刊JOURNAL OF MEDICINAL CHEMISTRY
ISSN0022-2623
2021-03-25
卷号64期号:6页码:2967-2970
DOI10.1021/acs.jmedchem.1c00433
通讯作者Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要Both nitroreductase and the folate receptor are highly expressed in hypoxic tumors. The folate receptor is a potential target for tumors, and nitroreductase can selectively turn on the fluorescence of probes by reducing the nitro group to an amino group. Karan et al. (Karana, S., Cho, M., Lee, H., Lee, H., Park, H., Sundararajan, M., Sessler, J., and Hong, K. Near-infrared fluorescent probe activated by nitroreductase for in vitro and in vivo hypoxic tumor detection. J. Med. Chem. 2021) developed a near-infrared fluorescent probe for hypoxia tumor imaging analysis in vitro and in vivo using folate as the targeting site. This promising strategy may promote advances in precision diagnosis and treatment models of malignant tumors. This Viewpoint looks ahead to new possibilities rendered by their studies.
资助机构National Natural Science Foundation of China; Taishan Scholar Project Special Funding
收录类别SCI
语种英语
研究领域[WOS]Pharmacology & Pharmacy
WOS记录号WOS:000635440600007
引用统计被引频次：5[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/27236
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Chen, Lingxin作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714Wang, Yue,Chen, Lingxin. Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor[J]. JOURNAL OF MEDICINAL CHEMISTRY,2021,64(6):2967-2970.
APAWang, Yue,&Chen, Lingxin.(2021).Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor.JOURNAL OF MEDICINAL CHEMISTRY,64(6),2967-2970.
MLAWang, Yue,et al."Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor".JOURNAL OF MEDICINAL CHEMISTRY 64.6(2021):2967-2970.
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