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Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichod

本站小编 Free考研考试/2022-02-11

Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2
Shi, Zhen-Zhen1; Liu, Xiang-Hong1,2; Li, Xiao-Nian3; Ji, Nai-Yun1
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
2020-12-30
卷号68期号:52页码:15440-15448
关键词Trichoderma brevicompactumtrichothecenecupareneantifungal activityantimicroalgal activity
DOI10.1021/acs.jafc.0c05586
通讯作者Ji, Nai-Yun(nyji@yic.ac.cn)
英文摘要Eight new trichothecene derivatives, trichodermarins G-N (1-8), and two new cuparene derivatives, trichocuparins A (9) and B (10), as well as six known trichothecenes (11-16) were isolated from the fungal strain Trichoderma brevicompactum A-DL-9-2 obtained from the inner tissue of the marine red alga Chondria tenuissima. The structures and relative configurations of 1-10 were assigned by NMR and MS data, and the absolute configurations of 1, 2, and 9 were established by X-ray diffraction. Compound 8 features an aminosugar unit bond to the trichothecene framework for the first time, while 9 and 10 represent the first occurrence of cuparene sesquiterpenes in Trichoderma. All the isolates were assayed for growth inhibition of five phytopathogenic fungi (Botrytis cinerea, Cochliobolus miyabeanus, Fusarium oxysporum f. sp. cucumerium, Fusarium oxysporum f. sp. niveum, and Phomopsis asparagi) and four marine phytoplankton species (Amphidinium carterae, Heterocapsa circularisquama, Heterosigma akashiwo, and Prorocentrum donghaiense). Several of them exhibited significant inhibitory activities against the fungi and phytoplankton tested of which trichodermin (12) showed the highest antifungal and antimicroalgal activities with MIC and IC50 values being 4.0 and 0.82 mu g/mL, respectively.
资助机构Natural Science Foundation for Distinguished Young Scholars of Shandong Province; National Natural Science Foundation of China; Youth Innovation Promotion Association of CAS; Taishan Scholar Project Special Funding
收录类别SCI
语种英语
关键词[WOS]BOTRYTIS-CINEREA; BIOSYNTHESIS; DERIVATIVES; MYCOTOXINS; INHIBITORS; IMPACTS; BLOOMS
研究领域[WOS]Agriculture; Chemistry; Food Science & Technology
WOS记录号WOS:000605190400009
引用统计被引频次:6[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/26159
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室

通讯作者Ji, Nai-Yun作者单位1.Chinese Acad Sci, Ctr Ocean Megasci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

推荐引用方式
GB/T 7714Shi, Zhen-Zhen,Liu, Xiang-Hong,Li, Xiao-Nian,et al. Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(52):15440-15448.
APAShi, Zhen-Zhen,Liu, Xiang-Hong,Li, Xiao-Nian,&Ji, Nai-Yun.(2020).Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(52),15440-15448.
MLAShi, Zhen-Zhen,et al."Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.52(2020):15440-15448.


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