Wang, Yuting; Li, Lili
; Ye, Changqing; Yuan, Jingyi; Qin, Song发表期刊APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN0175-7598
2020-03
卷号104期号:8页码:3541-3554
关键词LACTOBACILLUS-REUTERIINDUCED OBESITYATTENUATE HYPERTENSIONINSULIN-RESISTANCEACIDRATSACTIVATIONGLUCOSEHUMANSADULTS
研究领域Biotechnology & Applied Microbiology
DOI10.1007/s00253-020-10449-7
产权排序[Wang, Yuting; Ye, Changqing] Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China; [Wang, Yuting; Li, Lili; Yuan, Jingyi; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Wang, Yuting; Li, Lili; Yuan, Jingyi; Qin, Song] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China; [Yuan, Jingyi] Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
通讯作者Li, Lili(llli@yic.ac.cn); Qin, Song(sqin@yic.ac.cn)
作者部门海岸带生物学与生物资源保护实验室
英文摘要Alginate oligosaccharides are associated with some beneficial health effects. Gut microbiota is one of the most recently identified factors in the development of several metabolic diseases induced by high-fat diet. Our objective was to evaluate how alginate oligosaccharides impact on high-fat diet-induced features of metabolic disorders and whether this impact is related to modulations in the modulation of the gut microbiota. C57BL/6J mice were fed with chow diet, high-fat diet, or high-fat diet supplemented with alginate oligosaccharides for 10 weeks. Alginate oligosaccharide treatment improved lipid metabolism, such as reducing levels of TG and LDL-C and inhibiting expression of lipogenesis genes. Alginate oligosaccharide administration reduced the levels of fasting blood glucose and increased the levels of serum insulin. Alginate oligosaccharide treatment was found to lower the expression of markers of inflammation, including IL1 beta and CD11c. Alginate oligosaccharide treatment modulated gut microbial communities and markedly prompted the growth of Akkermansia muciniphila, Lactobacillus reuteri, and Lactobacillus gasseri. Additionally, alginate oligosaccharide intervention significantly increased concentrations of short-chain fatty acids, such as acetic acid, propionic acid, and butyric acid, as well as decreased levels of endotoxin. Alginate oligosaccharides exert beneficial effects via alleviating metabolic metrics induced by high-fat diet, which is associated with increase in A. muciniphila, L. reuteri, and L. gasseri, as well as the release of microbiota-dependent short-chain fatty acids and inhibition of endotoxin levels.
文章类型Article
资助机构National Key R&D Program of China [2017YFC0506200]; Youth Innovation Promotion Association of Chinese Academy of Sciences [2018246]
收录类别SCI
语种英语
关键词[WOS]LACTOBACILLUS-REUTERI; INDUCED OBESITY; ATTENUATE HYPERTENSION; INSULIN-RESISTANCE; ACID; RATS; ACTIVATION; GLUCOSE; HUMANS; ADULTS
研究领域[WOS]Biotechnology & Applied Microbiology
WOS记录号WOS:000516798000002
引用统计被引频次：18[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/25084
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China;
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China;
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China;
4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714Wang, Yuting,Li, Lili,Ye, Changqing,et al. Alginate oligosaccharide improves lipid metabolism and inflammation by modulating gut microbiota in high-fat diet fed mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2020,104(8):3541-3554.
APAWang, Yuting,Li, Lili,Ye, Changqing,Yuan, Jingyi,&Qin, Song.(2020).Alginate oligosaccharide improves lipid metabolism and inflammation by modulating gut microbiota in high-fat diet fed mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,104(8),3541-3554.
MLAWang, Yuting,et al."Alginate oligosaccharide improves lipid metabolism and inflammation by modulating gut microbiota in high-fat diet fed mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 104.8(2020):3541-3554.
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