Wei, LJ; Mi, YQ; Zhang, JJ; Li, Q
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发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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ISSN0141-8130
2019-05-15
卷号129页码:1127-1132
关键词ChitosanQuaternaryAntifungal
研究领域Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
DOI10.1016/j.ijbiomac.2018.09.099
产权排序[Wei, Lijie; Mi, Yingqi; Zhang, Jingjing; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Wei, Lijie; Mi, Yingqi; Zhang, Jingjing; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
通讯作者Dong, Fang(fdong@yic.ac.cn); Guo, Zhanyong(zhanyongguo@hotmail.com)
作者部门海岸带生物资源高效利用研究与发展中心
英文摘要Chemical modification is one of the prominent methods used to improve the water solubility and bioactivity of chitosan. In this paper, a series of quaternary ammonium chitosan derivatives based on 6-O-chloroacetylated chitosan (CAClC) were successfully designed and synthesized. Detailed structural characterization was carried out by means of FT-IR, H-1 NMR spectroscopy, and elemental analysis. Furthermore, the antifungal activity against Botrytis cinerea, Gibberella zeae, and Physalospora piricola Nose was estimated using in vitro hypha measurements. Most of the quaternary ammonium chitosan derivatives showed an inhibitory index of >90% at 1.0 mg/mL and exhibited enhanced antifungal activity when compared to chitosan. On one hand, the higher density of positive charge contributed to the antifungal action. In addition, the inhibitory activity decreased roughly in the order of TriM [(CH3)(3)] > TriE (CH2CH3)(3)] > TriP [(CH2CH2CH3)(3)] > TriB [(CH2CH2CH2CH3)(3)]; NNTE (CH3)(2)(CH2CH3)] > NNTB [(CH3)(2)(CH2CH2CH2CH3)] > NNTK RCH3)(2)((CH2)(9)CH3)] at 1.0 mg/mL. The antifungal properties of all the quaternary ammonium chitosan derivatives against the targeted fungi decreased upon increasing the alkyl chain length. (C) 2018 Published by Elsevier B.V.
文章类型Article
资助机构National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156]; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015]; Yantai Science and Technology Development Plan [2015ZH078]; Technology Research Funds Projects of Ocean [2015418022-3]
收录类别SCI
语种英语
关键词[WOS]N-SUBSTITUTED CHITOSAN; OLIGOCHITOSAN; DYE
研究领域[WOS]Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WOS记录号WOS:000466621200119
引用统计被引频次:11[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24940
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714Wei, LJ,Mi, YQ,Zhang, JJ,et al. Evaluation of quaternary ammonium chitosan derivatives differing in the length of alkyl side-chain: Synthesis and antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,129:1127-1132.
APAWei, LJ,Mi, YQ,Zhang, JJ,Li, Q,Dong, F,&Guo, ZY.(2019).Evaluation of quaternary ammonium chitosan derivatives differing in the length of alkyl side-chain: Synthesis and antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,129,1127-1132.
MLAWei, LJ,et al."Evaluation of quaternary ammonium chitosan derivatives differing in the length of alkyl side-chain: Synthesis and antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 129(2019):1127-1132.
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