Liu, Q1; Li, WJ1
; Lu, LN3; Liu, B3; Du, ZN2; Qin, S1发表期刊JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN2096-5508
2019-09
卷号37期号:5页码:1678-1685
关键词phycocyanininflammatoryTLR2-MyD88-NF-kappa B signaling pathway
研究领域Limnology; Oceanography
DOI10.1007/s00343-019-8196-8
产权排序[Liu Qi
; Li Wenjun; Qin Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Liu Qi; Du Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Lu Lina; Liu Bin] Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China
通讯作者Du Zhenning(zhenning.du@163.com); Qin Song(sqin@yic.an.cn)
作者部门海岸带生物学与生物资源保护实验室
英文摘要Phycocyanin (PC), a natural algal protein, is reported for having anti-oxidant and antiinflammatory properties. We investigated its ability to attenuate lung inflammation in mice subjected to X-ray radiation. Male C57BL/6 mice were assigned to the control, total body irradiation, PC pretreatment, and PC treatment groups. Mice in the PC pretreatment group were gavaged with 200 mg/kg PC for 7 consecutive days before irradiation, and those in the PC treatment group were gavaged with 200 mg/kg PC for 7 consecutive days after irradiation. Lungs were collected on Day 7 after irradiation exposure. Hematoxylin and eosin staining of mouse lung sections showed considerable inflammation damage 7 days after irradiation compared with the control lung but a reduction in pathological injury in the PC treatment group. Pretreatment or treatment with PC significantly decreased levels of interleukin-6 and tumor necrosis factor-alpha in the lung, and also increased the relative mRNA expression of superoxide dismutase and glutathione. In vivo, PC significantly reduced the expression of Toll-like receptor TLR2, myeloid differentiation primary response Myd88, and nuclear factor NF-kappa B, at both the transcriptional and translation level. Taken together, these data indicated that PC attenuated lung inflammatory damage induced by radiation by blocking the TLR2-MyD88-NF-kappa B signaling pathway. Therefore, PC could be a protective agent against radiation-induced inflammatory damage in normal tissues.
文章类型Article
资助机构National Key Research and Development Program of China [2018YFD0901102]
收录类别SCI
语种英语
关键词[WOS]CELL LUNG-CANCER; RADIATION PNEUMONITIS; C-PHYCOCYANIN; FIBROSIS; RADIOTHERAPY
研究领域[WOS]Limnology; Oceanography
WOS记录号WOS:000484533400019
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24869
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Du, ZN; Qin, S作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China;
2.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China;
3.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式
GB/T 7714Liu, Q,Li, WJ,Lu, LN,et al. Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-kappa B signaling pathway[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2019,37(5):1678-1685.
APALiu, Q,Li, WJ,Lu, LN,Liu, B,Du, ZN,&Qin, S.(2019).Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-kappa B signaling pathway.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,37(5),1678-1685.
MLALiu, Q,et al."Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-kappa B signaling pathway".JOURNAL OF OCEANOLOGY AND LIMNOLOGY 37.5(2019):1678-1685.
PDF全文下载地址:
点我下载PDF
