Xie, YY; Li, WJ
; Lu, CY; Zhu, LM; Qin, S; Du, ZN发表期刊APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN0175-7598
2019-10
卷号103期号:20页码:8559-8569
关键词PhycocyaninPulmonary fibrosisCytokinesIntestinal microbiome
研究领域Biotechnology & Applied Microbiology
DOI10.1007/s00253-019-10018-7
产权排序[Xie, Yuanyuan; Li, Wenjun; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Xie, Yuanyuan; Du, Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Xie, Yuanyuan; Li, Wenjun; Qin, Song] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China; [Lu, Chenyang] Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China; [Zhu, Limeng] Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
通讯作者Qin, Song(sqin@yic.ac.cn); Du, Zhenning(zhenning.du@163.com)
作者部门海岸带生物学与生物资源保护实验室
英文摘要Phycocyanin (PC) is a light-harvesting protein isolated from Spirulina and has health benefits for a range of diseases including pulmonary fibrosis (PF). In this study, a bleomycin-induced pulmonary fibrosis model was used to determine whether PC attenuates PF and modulates the intestinal microbiota. The results showed that PC intervention attenuated the pulmonary fibrosis, demonstrated by hematoxylin-eosin staining (HE), Masson's trichrome staining, and lung dry-wet weight ratio, and PC significantly inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and lipopolysaccharide (LPS). Additionally, intestinal microbiota analysis revealed that PC intervention significantly increased the bacterial diversity and richness. Correlation analysis indicated that 9 families and 17 genes were significantly associated with at least 1 physiological index. And PC intervention significantly decreased the bacteria which is related to inflammation and dramatically increased the SCFAs-producing bacteria and probiotics. These data indicated that PC can decrease the pro-inflammatory cytokines and regulate the intestinal microbiota in BLM-induced PF mice.
文章类型Article
资助机构National Key Research and Development Program of China [2018YFD0901102]; Key Research and Development Program of Yantai [2019XDHZ101]
收录类别SCI
语种英语
关键词[WOS]C-PHYCOCYANIN; HELICOBACTER-PYLORI; ANTIOXIDANT; SPIRULINA
研究领域[WOS]Biotechnology & Applied Microbiology
WOS记录号WOS:000491439700024
引用统计被引频次：8[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24843
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China;
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China;
4.Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China;
5.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714Xie, YY,Li, WJ,Lu, CY,et al. The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(20):8559-8569.
APAXie, YY,Li, WJ,Lu, CY,Zhu, LM,Qin, S,&Du, ZN.(2019).The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(20),8559-8569.
MLAXie, YY,et al."The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.20(2019):8559-8569.
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