Phycocyanin Ameliorates Radiation-Induced Acute Intestinal Toxicity by Regulating the Effect of the

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Phycocyanin Ameliorates Radiation-Induced Acute Intestinal Toxicity by Regulating the Effect of the Gut Microbiota on the TLR4/Myd88/NF-kappa B Pathway
Lu, LN ; Li, WJ

; Sun, C ; Kang, SH ; Li, J

; Luo, XP ; Su, Q ; Liu, B

; Qin, S

发表期刊JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

ISSN0148-6071
2019
页码10
关键词gut microbiota intestinal injury phycocyanin radiation
研究领域Nutrition & Dietetics
DOI10.1002/jpen.1744
产权排序[Lu, Lina; Liu, Bin] Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou, Gansu, Peoples R China; [Lu, Lina; Qin, Song] Northwest Minzu Univ, Sch Chem Engn, Lanzhou, Gansu, Peoples R China; [Li, Wenjun; Kang, Shuhe; Li, Jia; Luo, Xingping; Su, Qiong] Chinese Acad Sci, Yantai Inst Costal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai, Peoples R China; [Li, Wenjun; Qin, Song] Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Shandong, Peoples R China; [Sun, Chao] Chinese Acad Sci, Inst Modern Phys, Lanzhou, Gansu, Peoples R China; [Liu, Bin] Lanzhou Univ, Sch Stomatol, Lanzhou, Gansu, Peoples R China
通讯作者Liu, Bin(binliu0736@126.com)
作者部门海岸带生物学与生物资源利用重点实验室
英文摘要Background Radiation-induced gastrointestinal syndrome, including nausea, diarrhea, and dehydration, contributes to morbidity and mortality after medical or industrial radiation exposure, which seriously affects patient quality of life after treatment. No safe and effective radiation countermeasure has been approved for clinical therapy. In this study, we aimed to investigate the potential protective effects of phycocyanin (PC) against radiation-induced acute intestinal injury. Materials and Methods C57BL/6 mice were orally administered 50 mg/kg PC once per day for 1 month before exposure to total-abdominal x-ray irradiation at a single dose of 12 Gy. The effects of PC on intestinal histopathology and integrity, gut microbiota, lipopolysaccharides (LPS), inflammatory cytokines, and Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (Myd88)/nuclear factor kappa B (NF-kappa B) signaling were evaluated. Results Severe histopathological damage, such as intestinal mucosal epithelial cell apoptosis, necrosis, and nuclear rupture, was most clearly observed 24 hours after total-abdominal x-ray irradiation. Intestinal integrity was damaged by irradiation, which manifested in reduced levels of the tight-junction proteins Claudin-1, Occludin, and zonula occludens-1(ZO-1). PC pretreatment significantly ameliorated radiation-induced intestinal injury. PC also modulated the gut microbiota composition, increasing the proportion of beneficial bacteria and decreasing that of harmful bacteria, which in turn lowered LPS levels and suppressed TLR4/Myd88/NF-kappa B pathway activation. Finally, levels of corresponding inflammatory cytokines, including tumor necrosis factor alpha and interleukin-6, were also downregulated. Conclusion PC protects against mouse intestinal injury from high-dose radiation by regulating the effect of the gut microbiota on the TLR4/Myd88/NF-kappa B pathway, suggesting PC as a promising natural radiation countermeasure.
文章类型Article; Early Access
资助机构National Key Research and Development Program of China [2018YFD0901102]; Key Research and Development Program of Yantai [Y933021011]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [11775280]; Northwest Minzu University's Double First-class and Characteristic Development Guide Special Funds-Chemistry Key Disciplines in Gansu Province [11080316]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [31920180020, 31920190013, 31920190018]
收录类别SCI
语种英语
关键词[WOS]INFLAMMATORY-BOWEL-DISEASE; C-PHYCOCYANIN; FECAL MICROBIOTA; MOUSE; PROTECTS; INJURY
研究领域[WOS]Nutrition & Dietetics
WOS记录号WOS:000498400500001
引用统计被引频次：7[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24811
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室

作者单位1.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou, Gansu, Peoples R China;
2.Northwest Minzu Univ, Sch Chem Engn, Lanzhou, Gansu, Peoples R China;
3.Chinese Acad Sci, Yantai Inst Costal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai, Peoples R China;
4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Shandong, Peoples R China;
5.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Gansu, Peoples R China;
6.Lanzhou Univ, Sch Stomatol, Lanzhou, Gansu, Peoples R China

推荐引用方式
GB/T 7714Lu, LN,Li, WJ,Sun, C,et al. Phycocyanin Ameliorates Radiation-Induced Acute Intestinal Toxicity by Regulating the Effect of the Gut Microbiota on the TLR4/Myd88/NF-kappa B Pathway[J]. JOURNAL OF PARENTERAL AND ENTERAL NUTRITION,2019:10.
APALu, LN.,Li, WJ.,Sun, C.,Kang, SH.,Li, J.,...&Qin, S.(2019).Phycocyanin Ameliorates Radiation-Induced Acute Intestinal Toxicity by Regulating the Effect of the Gut Microbiota on the TLR4/Myd88/NF-kappa B Pathway.JOURNAL OF PARENTERAL AND ENTERAL NUTRITION,10.
MLALu, LN,et al."Phycocyanin Ameliorates Radiation-Induced Acute Intestinal Toxicity by Regulating the Effect of the Gut Microbiota on the TLR4/Myd88/NF-kappa B Pathway".JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2019):10.

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