Lu, LN; Li, WJ
; Chen, LH; Su, Q; Wang, YB; Guo, Z; Lu, YJ; Liu, B; Qin, S发表期刊FUTURE ONCOLOGY
ISSN1479-6694
2019-12
卷号15期号:35页码:4105-4118
关键词cancerintestinal damageionizing radiationradiation enteritisradiation enteropathy
研究领域Oncology
DOI10.2217/fon-2019-0416
产权排序[Lu, Lina; Liu, Bin] Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China; [Li, Wenjun; Qin, Song] Chinese Acad Sci, Yantai Inst Costal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Lu, Lina; Chen, Lihua; Su, Qiong; Wang, Yanbin; Lu, Yongjuan] Northwest Minzu Univ, Sch Chem Engn, Lanzhou 730000, Gansu, Peoples R China; [Li, Wenjun; Qin, Song] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China; [Guo, Zhong] Northwest Minzu Univ, Med Coll, Lanzhou 730000, Gansu, Peoples R China; [Liu, Bin] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China
通讯作者Liu, Bin(binliu_edu@sina.com)
作者部门海岸带生物学与生物资源保护实验室
英文摘要Aim: To systematically review the prophylactic and therapeutic interventions for reducing the incidence or severity of intestinal symptoms among cancer patients receiving radiotherapy. Materials & methods: A literature search was conducted in the PubMed database using various search terms, including 'radiation enteritis', 'radiation enteropathy', 'radiation-induced intestinal disease', 'radiation-induced intestinal damage' and 'radiation mucositis'. The search was limited to in vivo studies, clinical trials and meta-analyses published in English with no limitation on publication date. Other relevant literature was identified based on the reference lists of selected studies. Results: The pathogenesis of acute and chronic radiation-induced intestinal damage as well as the prevention and treatment approaches were reviewed. Conclusion: There is inadequate evidence to strongly support the use of a particular strategy to reduce radiation-induced intestinal damage. More high-quality randomized controlled trials are required for interventions with limited evidence suggestive of potential benefits.
文章类型Review
资助机构National Key Research and Development Program of China [2018YFD0901102]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81560508, 51563022, 51562033]; Northwest Minzu University's Double First-class and Characteristic Development Guide Special Funds-Chemistry Key Disciplines in Gansu Province [11080316]
收录类别SCI
语种英语
关键词[WOS]RAT SMALL-INTESTINE; STEM-CELLS; IONIZING-RADIATION; GASTROINTESTINAL TOXICITY; INDUCED APOPTOSIS; STROMAL CELLS; UP-REGULATION; SMALL-BOWEL; INJURY; RADIOTHERAPY
研究领域[WOS]Oncology
WOS记录号WOS:000502552400010
引用统计被引频次：11[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24801
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China;
2.Chinese Acad Sci, Yantai Inst Costal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
3.Northwest Minzu Univ, Sch Chem Engn, Lanzhou 730000, Gansu, Peoples R China;
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China;
5.Northwest Minzu Univ, Med Coll, Lanzhou 730000, Gansu, Peoples R China;
6.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式
GB/T 7714Lu, LN,Li, WJ,Chen, LH,et al. Radiation-induced intestinal damage: latest molecular and clinical developments[J]. FUTURE ONCOLOGY,2019,15(35):4105-4118.
APALu, LN.,Li, WJ.,Chen, LH.,Su, Q.,Wang, YB.,...&Qin, S.(2019).Radiation-induced intestinal damage: latest molecular and clinical developments.FUTURE ONCOLOGY,15(35),4105-4118.
MLALu, LN,et al."Radiation-induced intestinal damage: latest molecular and clinical developments".FUTURE ONCOLOGY 15.35(2019):4105-4118.
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