Wei, Lijie; Li, Qing
; Chen, Yuan; Zhang, Jingjing; Mi, Yingqi; Dong, Fang; Lei, Chunqing; Guo, Zhanyong发表期刊CARBOHYDRATE POLYMERS
ISSN0144-8617
2019-02-15
卷号206页码:493-503
关键词ChitosanAntioxidant activityAntifungal activityImidazoleQuaternary
研究领域Chemistry; Polymer Science
DOI10.1016/j.carbpol.2018.11.022
产权排序[Wei, Lijie; Li, Qing; Chen, Yuan; Zhang, Jingjing; Mi, Yingqi; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Wei, Lijie; Chen, Yuan; Zhang, Jingjing; Mi, Yingqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Lei, Chunqing] Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China
作者部门海岸带生物资源高效利用研究与发展中心
英文摘要In this paper, a series of 6-O-imidazole-based quaternary ammonium chitosan derivatives via 6-O-chloroacetyl chitosan (CAClC) were successfully designed and synthesized. Detailed structural characterization was carried out by means of FTIR and H-1 NMR spectroscopy, and elemental analysis. Furthermore, the antioxidant property against hydroxyl radicals, superoxide radicals, and DPPH radicals was evaluated in vitro. 2-(N,N,N-trimethyl)-6-O-(2-aminobenzimidazole)acetyl chitosan chloride (2NPhMC) and 2-(N,N,N-trimethyl)-6-O-(1-butylimidazole) acetyl chitosan chloride (NBMC) showed more than 90% scavenging indices at 1.6 mg/mL. Besides, the antifungal activity against Botrytis cinerea and Gibberella zeae was estimated using in vitro MIC and hypha measurements. Most of the quaternized chitosan derivatives especially with the long length alkyl chain and primary amino group showed an inhibitory index of > 85% at 1.0 mg/mL against Botrytis cinerea. Besides, the cytotoxicity of chitosan and all the quaternized chitosan derivatives was evaluated in vitro on HaCaT cells and all the quaternized chitosan derivatives bearing 6-O-imidazole exhibited low cytotoxicity. These results suggested that chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts may be used as good biomaterials.
文章类型Article
资助机构National Natural Science Foundation of China [41576156]; seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011]; Natural Science Foundation of Shandong Province of China [ZR 2017BD015]; Science and Technology Service Network Initiative of Chinese Academy of sciences [KFJ-STSZDTP-023]
收录类别SCI
语种英语
关键词[WOS]MEMBRANE-LIPID MONOLAYERS.; N-SUBSTITUTED CHITOSAN; ANTIMICROBIAL ACTIVITY; SUBPHASE DISTURBANT; SCAVENGING ACTIVITY; STARCH DERIVATIVES; ANTIBACTERIAL; DESIGN; TEMPERATURE; ANTITUMOR
研究领域[WOS]Chemistry, Applied; Chemistry, Organic; Polymer Science
WOS记录号WOS:000452982700056
引用统计被引频次：29[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24637
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714Wei, Lijie,Li, Qing,Chen, Yuan,et al. Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts[J]. CARBOHYDRATE POLYMERS,2019,206:493-503.
APAWei, Lijie.,Li, Qing.,Chen, Yuan.,Zhang, Jingjing.,Mi, Yingqi.,...&Guo, Zhanyong.(2019).Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts.CARBOHYDRATE POLYMERS,206,493-503.
MLAWei, Lijie,et al."Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts".CARBOHYDRATE POLYMERS 206(2019):493-503.
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