Chen, Yuan; Mi, Yingqi; Zhang, Jingjing; Dong, Fang
; Li, Qing; Ji, Naiyun; Guo, Zhanyong发表期刊POLYMERS
ISSN2073-4360
2018-12
卷号10期号:12页码:1295
关键词cationic inulin derivativesfree radicalsradical scavenging activityamino-pyridine group
研究领域Polymer Science
DOI10.3390/polym10121295
产权排序[Chen, Yuan; Mi, Yingqi; Zhang, Jingjing; Dong, Fang; Li, Qing; Ji, Naiyun; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Chen, Yuan; Mi, Yingqi; Zhang, Jingjing; Ji, Naiyun; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
作者部门海岸带生物资源高效利用研究与发展中心
英文摘要Many saccharides are attractive targets for biomaterial applications, due to their abundance, biocompatibility, and biodegradability. In this article, a synthesis process of 6-N-substituted cationic inulin derivatives, including 6-pyridyl-6-deoxyinulin bromide (PIL), 6-(2-amino-pyridyl)-6-deoxyinulin bromide (2APIL), 6-(3-amino-pyridyl)-6-deoxyinulin bromide (3APIL), 6-(4-amino-pyridyl)-6-deoxyinulin bromide (4APIL), 6-(2,3-diamino-pyridyl)-6-deoxyinulin bromide (2,3DAPIL), 6-(3,4-diamino-pyridyl)-6-deoxyinulin bromide (3,4DAPIL), and 6-(2,6-diamino-pyridyl)-6-deoxyinulin bromide (2,6DAPIL) was described. The C-6-OH of inulin was first activated by PPh3/N-bromosuccinimide (NBS) bromination. Then, pyridine and different kinds of amino-pyridine groups (different position and different numbers of amino) were grafted onto inulin, respectively, via nucleophilic substitution. Then, we confirmed their structure by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance (NMR) spectroscopy. After this, their radical scavenging activities against hydroxyl radical and diphenylpicryl phenylhydrazine (DPPH) radical were tested in vitro. Each derivative showed a distinct improvement in radical scavenging activity when compared to inulin. The hydroxyl-radical scavenging effect decreased in the following order: 3APIL > PIL > 3,4DAPIL > 4APIL > 2,3DAPIL > 2,6DAPIL > 2APIL. Amongst them, 3APIL revealed the most powerful scavenging effect on hydroxyl radicals, as well as DPPH radicals. At 1.6 mg/mL, it could completely eliminate hydroxyl radicals and could clear 65% of DPPH radicals. The results also showed that the steric hindrance effect and the substitute position of the amino group had an effect on the radical scavenging activity. Moreover, the application prospects of inulin derivatives as natural antioxidant biomaterials are scientifically proven in this paper.
文章类型Article
资助机构National Natural Science Foundation of China [41576156]; Natural Science Foundation of Shandong Province of China [ZR2017BD015]; Yantai Science and Technology Development Plan [2015ZH078]; Technology Research Funds Projects of Ocean [2015418022-3]
收录类别SCI
语种英语
关键词[WOS]ANTIOXIDANT ACTIVITIES; ANTIMICROBIAL ACTIVITY; CHEMICAL-MODIFICATIONS; CHITOSAN; ANTIBACTERIAL; FLOCCULANTS; PEPTIDES; KINETICS
研究领域[WOS]Polymer Science
WOS记录号WOS:000454748700003
引用统计被引频次：2[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24597
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714Chen, Yuan,Mi, Yingqi,Zhang, Jingjing,et al. Radical Scavenging Activities of Novel Cationic Inulin Derivatives[J]. POLYMERS,2018,10(12):1295.
APAChen, Yuan.,Mi, Yingqi.,Zhang, Jingjing.,Dong, Fang.,Li, Qing.,...&Guo, Zhanyong.(2018).Radical Scavenging Activities of Novel Cationic Inulin Derivatives.POLYMERS,10(12),1295.
MLAChen, Yuan,et al."Radical Scavenging Activities of Novel Cationic Inulin Derivatives".POLYMERS 10.12(2018):1295.
PDF全文下载地址:
点我下载PDF
