Tan, Wenqiang
; Zhang, Jingjing; Zhao, Xiang; Dong, Fang; Li, Qing; Guo, Zhanyong发表期刊CARBOHYDRATE POLYMERS
ISSN0144-8617
2018-11-01
卷号199页码:583-592
关键词Chitosan derivativesAminoAcylhydrazine1,2,3-Triazole1,2,3-TriazoliumAntioxidant activity
研究领域Chemistry; Polymer Science
DOI10.1016/j.carbpol.2018.07.056
产权排序[Tan, Wenqiang; Zhang, Jingjing; Dong, Fang; Li, Qing; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Tan, Wenqiang; Zhang, Jingjing; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Zhao, Xiang] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China
作者部门海岸带生物资源高效利用研究与发展中心
英文摘要Amino functionality has been paid growing attention in chemical modification of polysaccharides due to their potential biomedical applications. Here, the preparation of novel antioxidant materials based on chitosan derivatives bearing amino-containing groups equipped with 1,2,3-triazole and 1,2,3-triazolium by Cuprous-catalyzed azide-alkyne cycloaddition and N-methylation was described for the first time. The structural characteristics of the synthesized derivatives were examined by FTIR, H-1 NMR, and elemental analysis. The antioxidant activities of the chitosan derivatives were assessed in vitro. The results indicated that chitosan derivatives bearing 1,2,3-triazoles displayed superior antioxidant activity over pristine chitosan, especially against superoxide anion radical. Moreover, antioxidant efficiency of chitosan derivatives further enhanced after N-methylation of 1,2,3-triazole moieties with iodomethane, which is comparative to that of ascorbic acid. Notably, of all chitosan derivatives bearing 1,2,3-triazole or 1,2,3-triazolium moieties, acylhydrazine-functionalized and amino-functionalized chitosan showed the stronger antioxidant capacity than hydroxyl-modified chitosan at the test concentration. Besides, the cytotoxicities of them were also evaluated in vitro on HaCaT cells. These results suggested that amino and acylhydrazine-functionalized chitosan derivatives with 1,2,3-triazolium could be used as novel antioxidant biomaterials.
文章类型Article
资助机构National Natural Science Foundation of China [41576156]; Natural Science Foundation of Shandong Province of China [ZR2017BD015]; Science and Technology Service Network Initiative of Chinese academy of sciences [KFJ-STS-ZDTP-023]; Public Science and Technology Research Funds Projects of Ocean [201505022-3]
收录类别SCI
语种英语
关键词[WOS]IN-VITRO; CARBOXYMETHYL CHITOSAN; CHEMISTRY; ACID; 6-AMINO-6-DEOXYCHITOSAN; CARRIER
研究领域[WOS]Chemistry, Applied; Chemistry, Organic; Polymer Science
WOS记录号WOS:000442348500063
引用统计被引频次：21[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24556
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714Tan, Wenqiang,Zhang, Jingjing,Zhao, Xiang,et al. Synthesis and antioxidant action of chitosan derivatives with amino-containing groups via azide-alkyne click reaction and N-methylation[J]. CARBOHYDRATE POLYMERS,2018,199:583-592.
APATan, Wenqiang,Zhang, Jingjing,Zhao, Xiang,Dong, Fang,Li, Qing,&Guo, Zhanyong.(2018).Synthesis and antioxidant action of chitosan derivatives with amino-containing groups via azide-alkyne click reaction and N-methylation.CARBOHYDRATE POLYMERS,199,583-592.
MLATan, Wenqiang,et al."Synthesis and antioxidant action of chitosan derivatives with amino-containing groups via azide-alkyne click reaction and N-methylation".CARBOHYDRATE POLYMERS 199(2018):583-592.
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