Wei, Lijie; Chen, Yuan; Tan, Wenqiang
; Li, Qing; Gu, Guodong; Dong, Fang; Guo, Zhanyong发表期刊MOLECULES
ISSN1420-3049
2018-10
卷号23期号:10页码:2604-
关键词chitosanpyridinequaternizedantifungal
研究领域Biochemistry & Molecular Biology; Chemistry
DOI10.3390/molecules23102604
产权排序[Wei, Lijie; Chen, Yuan; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Wei, Lijie; Chen, Yuan; Tan, Wenqiang; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
作者部门海岸带生物资源高效利用研究与发展中心
英文摘要In this study, a series of triple quaternized chitosan derivatives, including 6-O-[(2-hydroxy-3-trimethylammonium)propyl]-2-N-(1-pyridylmethyl-2-ylmethyl)-N,N-dimethyl chitosan chloride (7), 6-O-[(2-hydroxy-3-trimethylammonium) propyl]-2-N-(1-pyridylmethyl-3-yl-methyl)-N, N-dimethyl chitosan chloride (8), and 6-O-[(2-hydroxy-3-trimethylammonium) propyl]2-N-(1-pyridylmethyl-4-ylmethyl)-N,N-dimethyl chitosan chloride (9) were successfully designed and synthesized via reacting epoxypropyl trimethylammonium chloride with the N-pyridinium double quaternized chitosan derivatives. Detailed structural characterization was carried out using FT-IR and H-1-NMR spectroscopy, and elemental analysis. Besides, the activity of the triple quaternized chitosan derivatives against three common plant pathogenic fungi, Watermelon fusarium, Fusarium oxysporum, and Phomopsis asparagi, was investigated in vitro. The results indicated that the triple quaternized chitosan derivatives had enhanced antifungal activity when compared to double quaternized chitosan derivatives and chitosan, especially at 1.0 mg/mL, which confirmed the theory that the higher density of positive charge contributed to the antifungal activity. Moreover, 8 with an almost 99% inhibitory index showed the better antifungal activity against Watermelon fusarium. Moreover, the cytotoxicity of the products was also evaluated in vitro on 3T3-L1 cells and all the triple quaternized chitosan derivatives exhibited low cytotoxicity. These results suggested that triple quaternized chitosan derivatives may be used as good antifungal biomaterials.
文章类型Article
资助机构National Natural Science Foundation of China [41576156]; Natural Science Foundation of Shandong Province of China [ZR2017BD015]; Yantai Science and Technology Development Plan [2015ZH078]; Technology Research Funds Projects of Ocean [2015418022-3]; seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011]
收录类别SCI
语种英语
关键词[WOS]N-SUBSTITUTED CHITOSAN; F-SP CUCUMERINUM; SCAVENGING ACTIVITY; ASSAY
研究领域[WOS]Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WOS记录号WOS:000451201400200
引用统计被引频次：5[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24547
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
推荐引用方式
GB/T 7714Wei, Lijie,Chen, Yuan,Tan, Wenqiang,et al. Synthesis, Characterization, and Antifungal Activity of Pyridine-Based Triple Quaternized Chitosan Derivatives[J]. MOLECULES,2018,23(10):2604-.
APAWei, Lijie.,Chen, Yuan.,Tan, Wenqiang.,Li, Qing.,Gu, Guodong.,...&Guo, Zhanyong.(2018).Synthesis, Characterization, and Antifungal Activity of Pyridine-Based Triple Quaternized Chitosan Derivatives.MOLECULES,23(10),2604-.
MLAWei, Lijie,et al."Synthesis, Characterization, and Antifungal Activity of Pyridine-Based Triple Quaternized Chitosan Derivatives".MOLECULES 23.10(2018):2604-.
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