Lv, Min
; Lo, Ching; Hsu, Cheng-Chih; Wang, Yuwen; Chiang, Yin-Ru; Sun, Qian; Wu, Yang; Li, Yan; Chen, Lingxin; Yu, Chang-Ping发表期刊FRONTIERS IN MICROBIOLOGY
ISSN1664-302X
2018-09-07
卷号9页码:2115
关键词metoprolol (MPL)microalgaeenantioselective biodegradationtransformation productsbiodegradation pathwayMS/MS spectral similarity networking
研究领域Microbiology
DOI10.3389/fmicb.2018.02115
产权排序[Lv, Min; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai, Peoples R China; [Lv, Min; Yu, Chang-Ping] Natl Taiwan Univ, Grad Inst Environm Engn, Taipei, Taiwan; [Lo, Ching; Hsu, Cheng-Chih] Natl Taiwan Univ, Dept Chem, Taipei, Taiwan; [Wang, Yuwen; Sun, Qian; Wu, Yang; Li, Yan] Chinese Acad Sci, Inst Urban Environm, CAS Key Lab Urban Pollutant Convers, Xiamen, Peoples R China; [Chiang, Yin-Ru] Acad Sinica, Biodivers Res Ctr, Taipei, Taiwan
作者部门海岸带环境工程技术研究与发展中心
英文摘要Metoprolol (MPL) is a chiral beta-blocker ubiquitously detected in various environments due to its low to moderate removal in wastewater treatment plants. This study was conducted to test the potential of using microalgae to degrade emerging contaminant MPL and to characterize the enantiomeric enrichment during MPL degradation by microalgae. The results showed that PO43--P, NO3--N and MPL could be simultaneously removed in the synthetic effluent by the targeted microalgae species, indicating microalgae were promising in wastewater treatment. Stereoselectivity was observed during MPL degradation by microalgae, with R-form enrichment. A marginal linear relationship between MPL degradation and enantiomeric enrichment was observed, implying that the enantiomeric tool, used as a quantitative indicator of biodegradation, could possibly be applied in MPL degradation by microalgae. An efficient liquid chromatograph tandem high resolution mass spectrometry (LC-HRMS/MS) chiral analytical method was developed to identify transformation products (TPs). The results showed that MS/MS spectral similarity networking could be used as a powerful tool to quickly identify unknown TPs. A total of 6 pairs of chiral TPs were identified, among which two new TPs of MPL including hydroxy{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetic acid (alpha-HMPLA) and 4-[2-Hydroxy-3-(isopropylamino)propoxy]benzaldehyde (DMPLD) were firstly reported, and proposed transformation pathways of MPL by microalgae were given. Considering the paired TPs detected and that the degradation of the two enantiomers followed first order kinetics, the two enantiomers likely had the same degradation mechanism.
文章类型Article
资助机构MOST, Taiwan [105-2113-M-002-004-MY2, 105-2221-E-002-009-MY3]; Center for Emerging Materials and Advanced Devices, National Taiwan University [NTU-ERP-106R880211, 106R880219]; NSFC [41601525]; NSF of Shandong province [ZR2016DB07]
收录类别SCI
语种英语
关键词[WOS]PERSONAL CARE PRODUCTS; WATER TREATMENT PLANTS; WASTE-WATER; MASS-SPECTROMETRY; OXIDATIVE-METABOLISM; ILLICIT DRUGS; PHARMACEUTICALS; REMOVAL; CHINA; BIODEGRADATION
研究领域[WOS]Microbiology
WOS记录号WOS:000443981000001
引用统计被引频次：12[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24531
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai, Peoples R China;
2.Natl Taiwan Univ, Grad Inst Environm Engn, Taipei, Taiwan;
3.Natl Taiwan Univ, Dept Chem, Taipei, Taiwan;
4.Chinese Acad Sci, Inst Urban Environm, CAS Key Lab Urban Pollutant Convers, Xiamen, Peoples R China;
5.Acad Sinica, Biodivers Res Ctr, Taipei, Taiwan
推荐引用方式
GB/T 7714Lv, Min,Lo, Ching,Hsu, Cheng-Chih,et al. Identification of Enantiomeric Byproducts During Microalgae-Mediated Transformation of Metoprolol by MS/MS Spectrum Based Networking[J]. FRONTIERS IN MICROBIOLOGY,2018,9:2115.
APALv, Min.,Lo, Ching.,Hsu, Cheng-Chih.,Wang, Yuwen.,Chiang, Yin-Ru.,...&Yu, Chang-Ping.(2018).Identification of Enantiomeric Byproducts During Microalgae-Mediated Transformation of Metoprolol by MS/MS Spectrum Based Networking.FRONTIERS IN MICROBIOLOGY,9,2115.
MLALv, Min,et al."Identification of Enantiomeric Byproducts During Microalgae-Mediated Transformation of Metoprolol by MS/MS Spectrum Based Networking".FRONTIERS IN MICROBIOLOGY 9(2018):2115.
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