Mi, Yingqi; Tan, Wenqiang
; Zhang, Jingjing; Wei, Lijie; Chen, Yuan; Li, Qing; Dong, Fang; Guo, Zhanyong发表期刊MARINE DRUGS
ISSN1660-3397
2018-09
卷号16期号:9页码:315
关键词hydroxypropyltrimethyl ammonium chloride chitosanhalogenated acetateantifungal activityelectronegativity
研究领域Pharmacology & Pharmacy
DOI10.3390/md16090315
产权排序[Mi, Yingqi; Tan, Wenqiang; Zhang, Jingjing; Wei, Lijie; Chen, Yuan; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Mi, Yingqi; Tan, Wenqiang; Zhang, Jingjing; Wei, Lijie; Chen, Yuan; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
作者部门海岸带生物资源高效利用研究与发展中心
英文摘要Hydroxypropyltrimethyl ammonium chitosan halogenated acetates were successfully synthesized from six different haloacetic acids and hydroxypropyltrimethyl ammonium chloride chitosan (HACC) with high substitution degree, which are hydroxypropyltrimethyl ammonium chitosan bromacetate (HACBA), hydroxypropyltrimethyl ammonium chitosan chloroacetate (HACCA), hydroxypropyltrimethyl ammonium chitosan dichloroacetate (HACDCA), hydroxypropyltrimethyl ammonium chitosan trichloroacetate (HACTCA), hydroxypropyltrimethyl ammonium chitosan difluoroacetate (HACDFA), and hydroxypropyltrimethyl ammonium chitosan trifluoroacetate (HACTFA). These chitosan derivatives were synthesized by two steps: first, the hydroxypropyltrimethyl ammonium chloride chitosan was synthesized by chitosan and 3-chloro-2-hydroxypropyltrimethyl ammonium chloride. Then, hydroxypropyltrimethyl ammonium chitosan halogenated acetates were synthesized via ion exchange. The structures of chitosan derivatives were characterized by Fourier transform infrared spectroscopy (FTIR), H-1 Nuclear magnetic resonance spectrometer (H-1 NMR), C-13 Nuclear magnetic resonance spectrometer (C-13 NMR), and elemental analysis. Their antifungal activities against Colletotrichum lagenarium, Fusarium graminearum, Botrytis cinerea, and Phomopsis asparagi were investigated by hypha measurement in vitro. The results revealed that hydroxypropyltrimethyl ammonium chitosan halogenated acetates had better antifungal activities than chitosan and HACC. In particular, the inhibitory activity decreased in the order: HACTFA > HACDFA > HACTCA > HACDCA > HACCA > HACBA > HACC > chitosan, which was consistent with the electron-withdrawing property of different halogenated acetates. This experiment provides a potential idea for the preparation of new antifungal drugs by chitosan.
文章类型Article
资助机构National Natural Science Foundation of China [41576156]; Shandong Province Science and Technology Development Plan [2015GSF121045]; Yantai Science and Technology Development Plan [2015ZH078]; Technology Research Funds Projects of Ocean [2015418022-3]
收录类别SCI
语种英语
关键词[WOS]QUATERNARY AMMONIUM; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; FUSARIUM-GRAMINEARUM; ANTIOXIDANT ACTIVITY; CHLORIDE CHITOSAN; SPECIES COMPLEX; IN-VITRO; DERIVATIVES; NANOPARTICLES
研究领域[WOS]Chemistry, Medicinal
WOS记录号WOS:000445636600026
引用统计被引频次：13[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24523
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714Mi, Yingqi,Tan, Wenqiang,Zhang, Jingjing,et al. Synthesis, Characterization, and Antifungal Property of Hydroxypropyltrimethyl Ammonium Chitosan Halogenated Acetates[J]. MARINE DRUGS,2018,16(9):315.
APAMi, Yingqi.,Tan, Wenqiang.,Zhang, Jingjing.,Wei, Lijie.,Chen, Yuan.,...&Guo, Zhanyong.(2018).Synthesis, Characterization, and Antifungal Property of Hydroxypropyltrimethyl Ammonium Chitosan Halogenated Acetates.MARINE DRUGS,16(9),315.
MLAMi, Yingqi,et al."Synthesis, Characterization, and Antifungal Property of Hydroxypropyltrimethyl Ammonium Chitosan Halogenated Acetates".MARINE DRUGS 16.9(2018):315.
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