Wu, Huifeng
; Zhong, Mingyu; Lu, Zhen; Shan, Xiujuan; Li, Fei; Ji, Chenglong; Cong, Ming发表期刊ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
2018-07
卷号61页码:102-106
关键词Organophosphate flame retardants (OPFRs)Tris (2-chloropropyl) phosphate (TCPP)Biological effectsInununityMytilus galloprovincialis
研究领域Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
DOI10.1016/j.etap.2018.05.022
产权排序[Wu, Huifeng; Zhong, Mingyu; Lu, Zhen; Li, Fei; Ji, Chenglong; Cong, Ming] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res,YICCAS, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China; [Wu, Huifeng; Shan, Xiujuan; Ji, Chenglong] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Zhong, Mingyu; Lu, Zhen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
作者部门海岸带环境过程实验室
英文摘要Organophosphate flame retardants (OPFRs) are increasingly produced and used as alternatives of brominated flame-retardants (BFRs) and have become emerging marine environmental contaminants. So far, however, little is known regarding the biological effects of OPFRs in marine organisms. In this study, the biological effects of one of the most abundant OPFRs, tris (1-chloro-2-propyl) phosphate (TCPP), on the immunity in mussel Mytilus galloprovincialis were characterized by testing the reactive oxygen species, apoptosis, antioxidant system and immunity related gene expressions. Results indicated that both TCPP exposures (10 and 100 nmol L-1) significantly (p < 0.01) enhanced reactive oxygen species production and the high dose of TCPP induced more apoptosis and oxidative stress in mussel hemocytes. TCPP also induced an obvious hormesis phenomenon (low dose inhibition and high dose stimulation) in mussel hemocytes, as indicated by the gene expression profiles of caspase 8 and mytimacin. The down-regulated gene expression levels of lysozymes suggested that both TCPP exposures inhibited the innate immunity in mussel M. galloprovincialis. The significantly (p < 0.01) increased gene expression levels of TLR, galectin, PGRP and LITAF demonstrated that TCPP induced dose-dependent immune stress in mussels. Overall, this work suggested that TCPP could influence the immune system in marine mussel M. galloprovincialis.
文章类型Article
资助机构National Key Basic Research Program of China [2015CB453303]; National Natural Science Foundation of China [21677173]; Youth Innovation Promotion Association CAS
收录类别SCI
语种英语
关键词[WOS]ORGANOPHOSPHORUS FLAME RETARDANTS; SPATIAL-DISTRIBUTION; SURFACE WATERS; YELLOW SEAS; PLASTICIZERS; EXPRESSION; CHINA; BOHAI; ACTIVATION; RECEPTORS
研究领域[WOS]Environmental Sciences; Pharmacology & Pharmacy; Toxicology
WOS记录号WOS:000437960800015
引用统计被引频次：11[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24442
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res,YICCAS, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China;
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714Wu, Huifeng,Zhong, Mingyu,Lu, Zhen,et al. Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2018,61:102-106.
APAWu, Huifeng.,Zhong, Mingyu.,Lu, Zhen.,Shan, Xiujuan.,Li, Fei.,...&Cong, Ming.(2018).Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,61,102-106.
MLAWu, Huifeng,et al."Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 61(2018):102-106.
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