Luan, Fang; Li, Qing
; Tan, Wenqiang; Wei, Lijie; Zhang, Jingjing; Dong, Fang; Gu, Guodong; Guo, Zhanyong发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
2018-02
卷号107页码:595-603
关键词Chitosan6-Amino-6-deoxychitosanAntioxidant abilityAntifungal activity
研究领域Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
DOI10.1016/j.ijbiomac.2017.09.028
产权排序[Luan, Fang; Li, Qing; Tan, Wenqiang; Wei, Lijie; Zhang, Jingjing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Luan, Fang; Tan, Wenqiang; Wei, Lijie; Zhang, Jingjing; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
作者部门海岸带生物资源高效利用研究与发展中心
英文摘要We synthesized 6-amino-6-deoxychitosan (NCS) through a series of reactions from chitosan (CS). The antioxidant ability of CS and NCS were investigated in vitro, including that of DPPH-radical and hydrogen peroxide, reducing power, chelating abilities and inhibition of lipid peroxidation. As expected, after the introduction of amino groups, antioxidant ability had improved significantly. Especially, scavenging effect against DPPH-radical and hydrogen peroxide of NCS were 97% and 92% at 1.6 mg/mL, respectively. Moreover, inhibition of lipid peroxidation was 57% at 0.1 mg/mL. And the reducing power of NCS was 0.68 at 0.8 mg/mL. Meanwhile, inhibitory effects against four fungi were also tested. Antifungal activity of NCS were better than those of CS and antifungal activity had improved more than 20% at 0.5 mg/mL against these four kinds of plant pathogens. Based on the above results, it was reasonable to speculate that the obtained antioxidant ability and antifungal activity of NCS might benefit from amino groups on chitosan backbone. These in vitro results suggest the possibility that NCS as antioxidant compound could be effectively alleviate oxidative stress and thus inhibit the oxidative mechanisms that lead to degenerative diseases. (C) 2017 Elsevier B.V. All rights reserved.
文章类型Article
资助机构Natural Science Foundation of China [41576156]; Shandong Province Science and Technology Development Plan [2015GSF121045]; Yantai Science and Technology Development Plan [2015ZH078]; Technology Research Funds Projects of Ocean [2015418022-3]
收录类别SCI
语种英语
关键词[WOS]CHEMICAL-MODIFICATIONS; SCAVENGING ACTIVITY; MOLECULAR-WEIGHT; SHIITAKE STIPES; CRAB SHELLS; CHITOSAN; CHITIN; DERIVATIVES; PEROXIDE; POLYSACCHARIDES
研究领域[WOS]Biochemistry & Molecular Biology; Chemistry; Polymer Science
WOS记录号WOS:000423892200068
引用统计被引频次：18[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24400
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
推荐引用方式
GB/T 7714Luan, Fang,Li, Qing,Tan, Wenqiang,et al. The evaluation of antioxidant and antifungal properties of 6-amino-6-deoxychitosan in vitro[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,107:595-603.
APALuan, Fang.,Li, Qing.,Tan, Wenqiang.,Wei, Lijie.,Zhang, Jingjing.,...&Guo, Zhanyong.(2018).The evaluation of antioxidant and antifungal properties of 6-amino-6-deoxychitosan in vitro.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,107,595-603.
MLALuan, Fang,et al."The evaluation of antioxidant and antifungal properties of 6-amino-6-deoxychitosan in vitro".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 107(2018):595-603.
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