Lv, Enguang; Ding, Jiawang
; Qin, Wei发表期刊SENSORS AND ACTUATORS B-CHEMICAL
ISSN0925-4005
2018-04-15
卷号259页码:463-466
关键词AptasensorBisphenol APotentiometrySurface chargeSolid state
研究领域Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
DOI10.1016/j.snb.2017.12.067
产权排序[Lv, Enguang; Ding, Jiawang; Qin, Wei] Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China; [Lv, Enguang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
作者部门海岸带环境过程实验室
英文摘要Solid-state potentiometric sensors based on surface charge change are well-established tools for measuring ions and biological species. However, their use for detection of small molecules with high sensitivity and good selectivity is still elusive. In this work, a novel potentiometric aptasensing platform for small molecules is presented, using bisphenol A (BPA) as a model. The proposed sensor can be prepared by layer-by-layer assembling of carboxylated multiwall carbon nanotubes, poly(diallyldimethylammonium chloride) (polycation), and aptamer (polyanion) on the electrode surface. The presence of BPA induces the conformational change and detachment of the aptamer at the surface of the modified electrode, which leads to a variation of the surface charge (negative to positive) and therefore a potential change. The introduction of polyions can cause substantial charge change on the electrode surface, thus improving the sensitivity of the sensor. The morphology and electron-transfer properties of the electrode have been characterized. Under optimum conditions, the present sensor shows a stable response to BPA in the concentration range from 3.2 x 10(-8) to 1.0 x 10(-6) M with a detection limit of 1.0 x 10(-8) M. The proposed methodology can be used for sensitive potentiometric sensing of other small molecules involved in aptamer/target binding events. (C) 2017 Elsevier B.V. All rights reserved.
文章类型Article
资助机构National Natural Science Foundation of China [21575158, 21475148]; National Key Research and Development Program of China [2016YFC1400700]; Instrument Developing Project of the Chinese Academy of Sciences [Y728021021]; CAS Youth Innovation Promotion Association [2014190]; Taishan Scholar Program of Shandong Province [TS20081159]
收录类别SCI
语种英语
关键词[WOS]ION-SELECTIVE ELECTRODES; MEMBRANE ELECTRODES; BISPHENOL-A; SENSORS; GOLD; COPPER(II); ADSORPTION; FILMS
研究领域[WOS]Chemistry; Electrochemistry; Instruments & Instrumentation
WOS记录号WOS:000424877600055
引用统计被引频次：14[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24375
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714Lv, Enguang,Ding, Jiawang,Qin, Wei. Potentiometric aptasensing of small molecules based on surface charge change[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,259:463-466.
APALv, Enguang,Ding, Jiawang,&Qin, Wei.(2018).Potentiometric aptasensing of small molecules based on surface charge change.SENSORS AND ACTUATORS B-CHEMICAL,259,463-466.
MLALv, Enguang,et al."Potentiometric aptasensing of small molecules based on surface charge change".SENSORS AND ACTUATORS B-CHEMICAL 259(2018):463-466.
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