Liang, RN
; Ding, JW; Gao, SS; Qin, W发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
2017-06-06
卷号56期号:24页码:6833-6837
关键词biological speciesbiosensorsimprintingmussel-inspired polymerspotentiometry
研究领域Chemistry, Multidisciplinary
DOI10.1002/anie.201701892
作者部门海岸带环境过程实验室
英文摘要Using sensors to quantify clinically relevant biological species has emerged as a fascinating research field due to their potential to revolutionize clinical diagnosis and therapeutic monitoring. Taking advantage of the wide utility in clinical analysis and low cost of potentiometric ion sensors, we demonstrate a method to use such ion sensors to quantify bioanalytes without chemical labels. This is achieved by combination of chronopotentiometry with a mussel-inspired surface imprinting technique. The biomimetic sensing method is based on a blocking mechanism by which the recognition reaction between the surface imprinted polymer and a bioanalyte can block the current-induced ion transfer of an indicator ion, thus causing a potential change. The present method offers high sensitivity and excellent selectivity for detection of biological analytes. As models, trypsin and yeast cells can be measured at levels down to 0.03 UmL(-1) and 50 CFUmL(-1), respectively.
文章类型Article
资助机构National Natural Science Foundation of China [21475148, 41576106, 41206087]; Science and Technology Project of Yantai [2014ZH086]; Youth Innovation Promotion Association of CAS [2014190]; Taishan Scholar Program of Shandong Province [TS20081159]
收录类别SCI
语种英语
关键词[WOS]biological species; biosensors; imprinting; mussel-inspired polymers; potentiometry
研究领域[WOS]Chemistry
WOS记录号WOS:000402523900023
引用统计被引频次：43[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24364
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714Liang, RN,Ding, JW,Gao, SS,et al. Mussel-Inspired Surface-Imprinted Sensors for Potentiometric Label-Free Detection of Biological Species[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(24):6833-6837.
APALiang, RN,Ding, JW,Gao, SS,&Qin, W.(2017).Mussel-Inspired Surface-Imprinted Sensors for Potentiometric Label-Free Detection of Biological Species.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(24),6833-6837.
MLALiang, RN,et al."Mussel-Inspired Surface-Imprinted Sensors for Potentiometric Label-Free Detection of Biological Species".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.24(2017):6833-6837.
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