生物科学与技术学院硕士研究生导师简介

Phetsang, W.,Daud, N.H., Deecke, J.E., Sidjabat, H.E., Ramaologa, S., Zuegg, J., Betley,J.R., Beevers, A.P.G., Smith, R.A.G., Roberts, J.A., Paterson, D.L., andCooper, M.A., Protein-inspired antibiotics active against vancomycin- anddaptomycin-resistant bacteria. Nature Communications, 2018. 9(1): p. 22.

6.Wan, J., Mobli, M., Brust, A., Muttenthaler, M.,Andersson, Å., Ragnarsson, L., Castro, J.,

Vetter, I., H uang, J.X.,Nilsson, M., Brierley, S.M., Cooper, M.A., Lewis, R.J., and Alewood,

P.F., Synthesisof Multivalent [Lys8]-Oxytocin Dendrimers that Inhibit Visceral NociceptiveResponses %J Australian Journal of Chemistry. 2017. 70(2): p. 162-171.

7.Schneider, E.K., H uang,J.X., Carbone, V., Han, M.,Zhu, Y., Nang, S., Khoo, K.K., Mak, J.,

Cooper, M.A., Li,J., and Velkov, T., Plasma Protein Binding Structure-Activity RelationshipsRelated to the N-Terminus of Daptomycin. ACS Infect Dis, 2017. 3: p. 249-258.

8.Grace, J.L., Elliott, A.G., Huang, J.X., Schneider, E.K.,Truong, N.P., Cooper, M.A., Li, J.,

Davis, T.P.,Quinn, J.F., Velkov, T.,and Whittaker, M.R., Cationic Acrylate Oligomers Comprising Amino Acid Mimic Moieties Demonstrate Improved Antibacterial Killing Efficiency.J Mater Chem B, 2017. 5(3): p. 531-536.

9.Becker, B., Butler,M.S., Hansford, K.A.,Gallardo-Godoy, A., Elliott,A.G., H uang, J.X.,

Edwards, D.J.,Blaskovich, M.A.T., and Cooper, M.A., Synthesis of octapeptin C4 and biologicalprofiling against NDM-1 and polymyxin-resistant bacteria. Bioorg Med Chem Lett,2017. 27(11): p. 2407-2409.

10.Schneider, E.K., Azad, M.A., Han, M.L., Tony Zhou, Q., Wang, J.,H uang, J.X., Cooper,

M.A., Doi, Y., Baker, M.A., Bergen, P.J., Muller, M.T., Li, J., and Velkov, T., An "Unlikely" Pair: TheAntimicrobial Synergy of Polymyxin B in Combination with the Cystic FibrosisTransmembrane Conductance Regulator Drugs KALYDECOand ORKAMBI. ACS Infect Dis, 2016. 2(7): p. 478-88.

11. Karunarathne, Deshapriya S.,Horne-Debets, Joshua M., Huang, Johnny X., Faleiro,R.,

Leow, Chiuan Y.,Amante, F., Watkins, Thomas S., Miles, John J., Dwyer, Patrick J., Stacey,Katryn J., Yarski, M., Poh, Chek M., Lee, Jason S., Cooper, Matthew A., Rénia,L., Richard, D., McCarthy, James S., Sharpe, Arlene H., and Wykes, Michelle N.,Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis IsEssential for Establishing CD4+ T Cell Immunity. Immunity, 2016. 45(2): p.333-345.

12.Johnson, S., Rahmani, R., Drew, D.R.,Williams, M.J., Wilkinson, M., Tan, Y.H., H

X.,Tonkin, C.J., Beeson, J.G., Baum, J., Smith, B.J., and Baell, J.B., Truncated

uang,

Latrunculinsas Actin Inhibitors Targeting Plasmodium falciparum Motility and Host CellInvasion. J Med Chem, 2016. 59(24): p. 10994-11005.

13.Grace, J.L., H uang, J.X., Cheah, S.E., Truong, N.P., Cooper,M.A., Li, J., Davis, T.P., Quinn,

J.F., Velkov,T., and Whittaker, M.R., Antibacterial Low Molecular Weight Cationic Polymers:Dissecting the Contribution of Hydrophobicity, Chain Length and Charge toActivity. RSC Adv, 2016. 6(19): p. 15469-15477.

14.Gallardo-Godoy, A., Muldoon,C., Becker, B., Elliott, A.G., Lash, L.H., H uang, J.X., Butler,

M.S., Pelingon, R., Kavanagh, A.M., Ramu, S.,Phetsang, W., Blaskovich, M.A., and Cooper, M.A., Activity and PredictedNephrotoxicity of Synthetic Antibiotics Based on Polymyxin B. J Med Chem, 2016. 59(3): p. 1068-77.

15.Beattie, K.D., Ellwood, N., Kumar, R.,Yang, X., Healy, P.C., Choomuenwai,V., Quinn, R.J.,

Elliott, A.G., H uang,J.X., Chitty, J.L., Fraser, J.A., Cooper, M.A., and Davis, R.A.,

Antibacterialand antifungal screening of natural products sourced from Australian fungi andcharacterisation of pestalactams D-F. Phytochemistry, 2016. 124: p. 79-85.

16. Baker, M.A., Schneider,E.K., H uang, J.X.,Cooper, M.A., Li, J., and Velkov, T.,The plasma

protein bindingproteome of ertapenem: A novel compound-centric proteomic approach forelucidating drug-plasma protein binding interactions. ACS Chem Biol, 2016.

17.Zuegg, J., Muldoon, C., Adamson, G.,McKeveney, D., Le Thanh, G., Premraj, R., Becker, B.,

Cheng, M., Elliott, A.G., H uang, J.X.,Butler, M.S., Bajaj, M., Seifert, J., Singh, L., Galley,

N.F., Roper, D.I., Lloyd, A.J., Dowson, C.G., Cheng, T.J., Cheng, W.C., Demon,D., Meyer, E., Meutermans, W., and Cooper, M.A., Carbohydratescaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nat Commun, 2015. 6: p. 7719.

18. Wan, J., H uang,J.X., Vetter, I., Mobli, M.,Lawson, J., Tae, H.S., Abraham, N.,Paul, B.,

Cooper, M.A.,Adams, D.J., Lewis, R.J., and Alewood, P.F., alpha-Conotoxin Dendrimers HaveEnhanced Potency and Selectivity for Homomeric Nicotinic AcetylcholineReceptors. J Am Chem Soc, 2015. 137(9): p. 3209-12.

19. Schneider, E.K., H uang, J.X., Carbone, V., Baker, M., Azad, M.A., Cooper, M.A., Li, J., and

Velkov, T.,Drug-drug plasma protein binding interactions of ivacaftor. J Mol Recognit,2015. 28(6): p. 339-48.

20. Rees, K.A., Bermudez, C.,Edwards, D.J., Elliott, A.G., Ripen,J.E., Seta, C., H uang, J.X.,

Cooper, M.A.,Fraser, J.A., Yeo, T.C., and Butler, M.S., Flemingin-Type Prenylated Chalconesfrom the Sarawak Rainforest Plant Desmodium congestum. J Nat Prod, 2015. 78(8):p. 2141-4.

21.Iscla, I., Wray, R., Blount, P., Larkins-Ford, J., Conery, A.L., Ausubel, F.M., Ramu, S.,

Kavanagh, A., Huang, J.X., Blaskovich, M.A., Cooper, M.A., Obregon-Henao, A., Orme, I.,

Tjandra, E.S., Stroeher, U.H.,Brown, M.H., Macardle, C., van Holst, N., Ling Tong, C.,

Slattery,A.D., Gibson, C.T., Raston, C.L., and Boulos, R.A., A new antibiotic withpotent activity targets MscL. J Antibiot (Tokyo), 2015.

22.H uang, J.X., Kaeslin, G., Ranall, M.V., Blaskovich, M.A., Becker,B., Butler, M.S., Little,

M.H., Lash,L.H., and Cooper, M.A., Evaluation of biomarkers for in vitro prediction ofdrug-induced nephrotoxicity: comparison of HK-2, immortalized human proximaltubule epithelial, and primary cultures of human proximal tubular cells.Pharmacol Res Perspect, 2015. 3(3): p. e00148.

23. H uang, J.X., Blaskovich, M.A., Pelingon, R., Ramu, S., Kavanagh, A., Elliott, A.G.,Butler,

M.S.,Montgomery, A.B., and Cooper, M.A., Mucin Binding Reduces ColistinAntimicrobial Activity. Antimicrob Agents Chemother, 2015. 59(10): p. 5925-31.

24.Hickey, S.M., Ashton, T.D.,White, J.M., Li, J., Nation,R.L., Yu, H.Y., Elliott, A.G., Butler,

M.S., H uang, J.X.,Cooper, M.A., and Pfeffer, F.M., Synthesis of Norbornane Bisether

Antibiotics via Silver-mediatedAlkylation. RSC Advances, 2015.

25.Hickey, S.M., Ashton, T.D.,Khosa, S.K., Robson, R.N., White, J.M., Li, J., Nation, R.L., Yu,

H.Y.,Elliott, A.G., Butler, M.S., H uang, J.X., Cooper, M.A., and Pfeffer, F.M., Synthesis and

evaluation ofcationic norbornanes as peptidomimetic antibacterial agents. Org Biomol Chem,2015. 13(22): p. 6225-41.

26. Carbone, V., Schneider, E.K., Rockman, S., Baker, M., H uang, J.X.,Ong, C., Cooper, M.A.,

Yuriev, E., Li,J., and Velkov, T., Molecular Characterisation of the HaemagglutininGlycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009H1N1 Swine Influenza A Virus. Molecules, 2015. 20(6): p. 10415-34.

27.Bi, S., Ranzoni, A., H uang,J.X., Hansford, K., and Cooper, M.A.,Affinities and in-plane

stress forcesbetween glycopeptide antibiotics and biomimetic bacterial membranes. Sensingand Bio-Sensing Research, 2015. 3(0): p. 24-30.

28. Bajaj, M., Mamidyala, S.K.,Zuegg, J., Begg, S.L., Ween, M.P., Luo, Z., H uang, J.X.,

McEwan, A.G.,Kobe, B., Paton, J.C., McDevitt, C.A., and Cooper, M.A., Discovery of NovelPneumococcal Surface Antigen A (PsaA) Inhibitors Using a Fragment-based DrugDesign Approach. ACS Chem Biol, 2015.

29.Azmi, F., Elliott, A.G., Khalil, Z.G., Hussein, W.M., Kavanagh,A., Huang, J.X., Quezada,

M., Blaskovich, M.A., Capon,R.J., Cooper, M.A., Skwarczynski, M., and Toth, I.,

Self-assemblinglipopeptides with a potent activity against Gram-positive bacteria, includingmultidrug resistant strains. Nanomedicine (Lond), 2015. 10(22): p. 3359-71.

30. Velkov,T., Deris,Z.Z., H uang, J.X., Azad, M.A., Butler, M.,Sivanesan, S., Kaminskas,

L.M.,Dong, Y.D., Boyd, B., Baker, M.A., Cooper, M.A., Nation, R.L., and Li, J.,Surface changes and polymyxin interactions with a resistant strain ofKlebsiella pneumoniae. Innate Immun, 2014. 20(4): p. 350-63.

31. Phetsang, W., Blaskovich, M.A., Butler, M.S., H uang, J.X., Zuegg, J., Mamidyala, S.K.,

Ramu, S.,Kavanagh, A.M., and Cooper, M.A., An azido-oxazolidinone antibiotic for livebacterial cell imaging and generation of antibiotic variants. Bioorg Med Chem,2014. 22(16): p. 4490-8.

32. H uang, J.X., Blaskovich, M.A., and Cooper, M.A., Cell- and biomarker-based assays for

predicting nephrotoxicity.Expert Opin Drug Metab Toxicol, 2014. 10(12): p. 1621-35.

33. Cheng, M., Huang, J.X., Ramu, S., Butler,M.S., and Cooper, M.A., Ramoplanin at

Bactericidal ConcentrationsInduces Bacterial Membrane Depolarization in Staphylococcus aureus. AntimicrobAgents Chemother, 2014. 58(11): p. 6819-27.

34. Velkov,T., Ong,C., Baker, M.A., Kim, H., Li, J., Nation, R.L., H uang, J.X., Cooper, M.A.,

and Rockman, S.,The antigenic architecture of the hemagglutinin of influenza H5N1 viruses. MolImmunol, 2013. 56(4): p. 705-19.

35.Mamidyala, S.K., Ramu, S., H uang, J.X.,Robertson, A.A., and Cooper, M.A., Efficient

synthesis ofanacardic acid analogues and their antibacterial activities. Bioorg Med ChemLett, 2013. 23(6): p. 1667-70.

36. Hu, D.F., Scott R.; H uang,Johnny X.; Ding, Xixia; Qiu, Liwen; Pan, Yuxian; Chen, Yue;

Jin, Jing;McElnea, Catriona; Buechler, Joe; Che, Xiaoyan; Cooper, Comparison of SurfacePlasmon Resonance, Resonant Waveguide Grating Biosensing and Enzyme LinkedImmunosorbent Assay (ELISA) in the Evaluation of a Dengue Virus Immunoassay.

Biosensors, 2013. 3(3): p. 297-311.

37. Carbone, V., Kim, H., H uang,J.X., Baker, M.A., Ong, C., Cooper, M.A., Li, J., Rockman,

S., and Velkov,T., Molecular characterization of the receptor binding structure-activityrelationships of influenza B virus hemagglutinin. Acta Virol, 2013. 57(3): p.313-32.

38. Velkov,T., Soon,R.L., Chong, P.L., Huang, J.X., Cooper, M.A., Azad, M.A., Baker, M.A.,

Thompson, P.E.,Roberts, K., Nation, R.L., Clements, A., Strugnell, R.A., and Li, J., Molecularbasis for the increased polymyxin susceptibility of Klebsiella pneumoniaestrains with under-acylated lipid A. Innate Immun, 2012.

39.Karoli, T., Mamidyala, S.K.,Zuegg, J., Fry, S.R., Tee, E.H., Bradford, T.A., Madala, P.K.,

H uang, J.X.,Ramu, S., Butler, M.S., and Cooper, M.A., Structure aided design ofchimeric

antibiotics. Bioorg Med ChemLett, 2012. 22(7): p. 2428-33.

40.Karoli, T., Becker, B., Zuegg, J., Mollmann, U.,Ramu, S., Huang, J.X., and Cooper, M.A.,

Identificationof antitubercular benzothiazinone compounds by ligand-based design. J Med Chem,2012. 55(17): p. 7940-4.

41. H uang, J.X., Cooper, M.A., Baker, M.A., Azad, M.A., Nation, R.L., Li, J., and Velkov, T.,

Drug-bindingenergetics of human alpha-1-acid glycoprotein assessed by isothermal titrationcalorimetry and molecular docking simulations. J Mol Recognit, 2012. 25(12): p.642-56.

42. H uang, J.X., Bishop-Hurley, S.L., and Cooper, M.A.,Development of Anti-Infectives using

Phage Display:Biological Agents against Bacteria, Viruses and Parasites. Antimicrob AgentsChemother, 2012.

43. H uang, J.X., Azad, M.A., Yuriev, E.,Baker, M.A., Nation, R.L., Li, J., Cooper, M.A., and

Velkov, T., MolecularCharacterization of Lipopolysaccharide Binding to Human alpha-1-AcidGlycoprotein. J Lipids, 2012. 2012: p. 475153.

44.Azad, M.A., H uang, J.X., Cooper,M.A., Roberts, K.D., Thompson, P.E., Nation,R.L., Li, J.,

and Velkov, T.,Structure-activity relationships for the binding of polymyxins with humanalpha-1-acid glycoprotein. Biochem Pharmacol, 2012. 84(3): p. 278-91.

45. Ueno, H., H uang, X., Tanaka, Y.,and Hirokawa, N., KIF16B/Rab14 molecular motor

complex iscritical for early embryonic development by transporting FGF receptor.Developmental Cell, 2011. 20(1): p. 60-71.

46. Fry, S.R., Meyer, M., Semple, M.G., Simmons, C.P., Sekaran,S.D., Huang, J.X., McElnea,

C., Huang, C.Y.,Valks, A., Young, P.R., and Cooper, M.A., The diagnostic sensitivity of denguerapid test assays is significantly enhanced by using a combined antigen andantibody testing approach. PLoS Negl Trop Dis, 2011. 5(6): p. e1199.

47.Tee, E.H., Karoli, T.,Ramu, S., H uang, J.X., Butler,M.S., and Cooper, M.A., Synthesis of

essramycin and comparison of itsantibacterial activity. J Nat Prod, 2010. 73(11): p. 1940-2.

代表性科研项目

1.潍坊医学院高层次人才启动基金，2019-2023

2.昆士兰大学先进基因编辑中心 CRISPR 基因编辑项目 56 项，2016-2018

3.昆士兰大学分子生物科学研究所资助项目, An IMB-UQ-QLD Health initiative to fight back against superbug infections, 2015.01-2015.12

4.Adenium 资助项目，Mode of action studyof Arenicin-3 analogues, 2013.01-2014.12

5.澳大利亚国家健康医学研究委员会资助项目, Non-haemolytic friulimicins for the treatment ofmulti-drug resistant bacteria, 2012.01-2014.12

6.澳大利亚国家健康医学研究委员会资助项目，Development of novel hybrid antibiotics for